Beyond biology: the impact of marital status on survival of patients with adrenocortical carcinoma

Klaassen, Zachary; Reinstatler, Lael; Terris, Martha K.; Underwood, Willie; Moses, Kelvin A.

doi:10.1590/s1677-5538.ibju.2014.0348

Cited by 3 publications

(4 citation statements)

References 15 publications

(20 reference statements)

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“…Our finding showed that married group had higher survival rate in patients of TNM stage I, II and IV. Although this correlation between marriage and cancer was supported by previous studies 18 – 22 , the reasons were not fully understood. Unlike unmarried ones, married patients are more likely to receive standard treatments and social support.…”

Section: Discussionmentioning

confidence: 52%

The influence of marital status on survival of gallbladder cancer patients: a population-based study

Liu

Wang

et al. 2017

Sci Rep

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Marital status has been found to be a prognostic factor for survival in various cancers, but its role in gallbladder cancer (GBC) has not been fully studied. In this study, we used the Surveillance, Epidemiology, and End Results Program (SEER)-registered database to analyze the survival of GBC patients with different marital status. A total of 6,627 GBC patients were selected from SEER database from 2004 to 2013. The age, race, grade, histologic type, AJCC stage, SEER stage and marital status were identified as independent prognostic factors. Married GBC patients had a higher 5-year cancer-specific survival (CSS) than that of unmarried ones (20.1% v.s. 17.8%, P < 0.05). Subgroup analyses showed that widowed patients had 14.0% less of 5-year CSS compared to married ones of stage I (55.9% v.s. 41.9%, P < 0.05), 14.7% of stage II (15.6% v.s. 10.9%, P < 0.05), and 1.5% of stage III + IV (2.9% v.s. 1.4%, P < 0.05). In addition, single is an independent prognostic factor at stage III + IV (HR = 1.225, 95%CI 1.054–1.423, P = 0.008). These results indicated that widowed patients were at a high risk of cancer-specific mortality and marriage can be a protective prognostic factor in CSS.

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Section: Discussionmentioning

confidence: 52%

The influence of marital status on survival of gallbladder cancer patients: a population-based study

Liu

Wang

et al. 2017

Sci Rep

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“…However, the study also found patient experiences and partner perspectives influences wellbeing. The effect of a supportive partner was identified by another study which found marital status had positive association ( p = .008) with ACC survival 39 . It has been suggested that this might be attributed by increased peer support for access to healthcare, treatment adherence and willingness to seek help.…”

Section: Discussionmentioning

confidence: 94%

“…The effect of a supportive partner was identified by another study which found marital status had positive association ( p = .008) with ACC survival. 39 It has been suggested that this might be attributed by increased peer support for access to healthcare, treatment adherence and willingness to seek help. These findings align with the themes in our systematic review and reinforce the case for qualitative research in people with AI/ACC.…”

Section: Discussionmentioning

confidence: 99%

Lived experience of people with adrenocortical carcinoma and associated adrenal insufficiency

Yeoh

Czuber‐Dochan

Aylwin

et al. 2022

Endocrino Diabet & Metabol

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Introduction: Adrenocortical carcinoma (ACC) is a rare cancer with an annual incidence of 0.7-2 cases per million population and 5-year survival of 31.2%. Adrenal insufficiency (AI) is a common and life shortening complication of ACC, and little is understood about how it impacts on patients' experience.Objective: To understand patients' lived experience of the condition, its treatment, care process, impact of AI on ACC wellbeing, self-care needs and support. Methods: Systematic review of MEDLINE, EMBASES, CINAHL, PsycINFO and OpenGrey for studies published until February 2021. All research designs were included.The findings underwent a thematic analysis and narrative synthesis. Studies quality was assessed using mixed method assessment tools.Results: A total of 2837 citations were identified; 15 titles with cohort, cross-sectional, case series and case report study designs met the inclusion criteria involving 479 participants with adrenal insufficiency secondary to adrenocortical carcinoma (AI/ACC).Quantitative research identified impacts of disease and treatment on survivorship, the burden of living with AI/ACC, toxicity of therapies, supporting self-care and AI management. These impact factors included adjuvant therapies involved and their toxicities, caregivers/family supports, healthcare and structure support in place, specialist skill and knowledge provided by healthcare professional on ACC management.No qualitative patient experiences evidence was identified.Conclusion: ACC appears to have high impact on patients' wellbeing including the challenges with self-care and managing AI. Evidence is needed to understand patient experience from a qualitative perspective.

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“…This finding is consistent with earlier research that showed metastatic disease and a more advanced stage to be independent predictive factors for OS and CSS ( Ayala-Ramirez et al, 2013 ). Zachary Klaassen showed that single, divorced, or widowed (SDW) patients have much higher cancer-specific death rates than married patients ( Klaassen et al, 2015 ). However, in our study, marital status was not related to survival in ACC patients.…”

Section: Discussionmentioning

confidence: 99%

The prognosis difference between elderly and younger patients with adrenocortical carcinoma

Huang²,

Zhao³

et al. 2023

Front. Genet.

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Background and aim: Adrenocortical carcinoma (ACC) is uncommon in the elderly. This study aimed to compare the surgical prognosis and survival between senior and younger patients. We also explored the factors that were independently related to the survival of elderly patients.Methods: We identified ACC patients between 2010 and 2019 in the Surveillance, Epidemiology, and End Results (SEER) database and applied Kaplan-Meier curves to evaluate the overall survival (OS) and cancer-specific survival (CSS) with log-rank tests. We also used Cox regression analysis to estimate the OS and CSS. The Fine and Gray model with the Gray test was used to measure the cumulative incidence function (CIF) of CSS and other mortality causes of patients in a competing-risks setting.Results: Of 876 patients, 44.06% were elderly. A lower proportion of elderly patients underwent surgery, regional lymph node surgery, and chemotherapy than young patients. Elderly patients also had inferior OS and CSS than younger patients. The 1- and 5-year OS of elderly patients who underwent surgery were 68% [95% confidence interval (CI): 62%–74%] and 30% (95% CI: 24%–38%), and the 1- and 5-year CSS were 73% (95% CI: 67%–80%) and 40% (95% CI: 32%–47%). The factors independently related to worsened survival included age ≥60 [Hazard Ratio (HR): 1.47 (1.24–1.75)], metastatic disease [HR: 1.90 (1.49–2.51)], higher grade [HR: 1.94 (1.08–3.46)] and Network for the Study of Adrenal Tumors (ENSAT) stage [HR: 1.99 (1.48–2.66)].Conclusion: Younger ACC patients had better survival than the elderly. Factors independently related to worsened survival in elderly patients included age ≥60, metastatic disease, higher grade, and European ENSAT stage.

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Beyond biology: the impact of marital status on survival of patients with adrenocortical carcinoma

Cited by 3 publications

References 15 publications

The influence of marital status on survival of gallbladder cancer patients: a population-based study

The influence of marital status on survival of gallbladder cancer patients: a population-based study

Lived experience of people with adrenocortical carcinoma and associated adrenal insufficiency

The prognosis difference between elderly and younger patients with adrenocortical carcinoma

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