2013
DOI: 10.1590/s1677-5538.ibju.2013.05.06
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Abstract: Purpose: The discovery of new diagnostic tools for the diagnosis of prostate cancer (PCa) has become an important field of research. In this study, we analyzed the diagnostic value of the expression of the pepsinogen C (PGC) and prostate-specific membrane antigen (PSMA) genes in tissue samples obtained from prostate biopsies. Materials and Methods: This study was comprised of 51 consecutive patients who underwent transrectal ultrasound (TRUS)-guided prostate biopsies between January 2010 and March 2010. The bi… Show more

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Cited by 7 publications
(8 citation statements)
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“…PGC expression levels were apparently promoted, especially in the tumour, for example, in prostate cancer, breast cancer, ovary cancer, endometrial cancer, pancreatic cancer, kidney cancer, bladder cancer, eyelid basal cell carcinoma, squamous cell carcinoma and melanoma, etc. [ 5 , 7 , 8 , 47 50 ]. It is worth noting that in sex-related tumours such as prostate cancer, breast cancer and ovary cancer, PGC expression is increased in cancer tissues as compared to normal tissues.…”
Section: Pgc Expression and Cancermentioning
confidence: 99%
See 1 more Smart Citation
“…PGC expression levels were apparently promoted, especially in the tumour, for example, in prostate cancer, breast cancer, ovary cancer, endometrial cancer, pancreatic cancer, kidney cancer, bladder cancer, eyelid basal cell carcinoma, squamous cell carcinoma and melanoma, etc. [ 5 , 7 , 8 , 47 50 ]. It is worth noting that in sex-related tumours such as prostate cancer, breast cancer and ovary cancer, PGC expression is increased in cancer tissues as compared to normal tissues.…”
Section: Pgc Expression and Cancermentioning
confidence: 99%
“…Serum PGC and its combination with PGA and the PGA/PGC ratio have a satisfactory sensitivity, specificity and price–quality ratio for predicting individuals at high risk for GC. Ectopic PGC expression levels are significantly increased in prostate cancer, breast cancer and ovary cancer [ 5 8 ]. In those sex-related cancers, high level PGC expression indicates a better prognosis and longer survival.…”
Section: Introductionmentioning
confidence: 99%
“…Although PGC has been defined as an important stomach proenzyme, its expression spectrum was actually varied in breast, prostate, pancreas and liver. The increased PGC expression was reported to be correlated with prostate cancer and HCC 16,21. However, changes in PGC may have gender-specific connotations.…”
Section: Discussionmentioning
confidence: 99%
“…1,5,14,15 Beside, PGC also have close relationship with ovarian cancer, 16 breast cancers, 10,17 and prostatic cancer. 8,18 PGA is expressed in esophageal squamous cell carcinoma. 11 In this study, through pan-cancer analysis, a panoramic view of PGs expression profile in all human cancers was first showed up and the results suggest that PGs, especially PGC, have characteristic of broad-spectrum expression in multiple cancers, which may made PGs be useful biomarkers for prediction/diagnosis/prognosis and effective targets for treatment in human cancer, which is an interesting and new research topic in the relevant fields.…”
Section: Discussionmentioning
confidence: 99%
“…7 Interestingly, recent studies have found that PGC can be ectopic expressed in tumor tissues that were not expressed initially, such as prostate cancer, breast cancer, ovarian cancer, endometrial cancer, pancreatic cancer, kidney cancer, bladder cancer, eyelid basal cell carcinoma, squamous cell carcinoma, melanoma, and so on. [8][9][10] PGA is expressed in esophageal squamous cell carcinoma. 11 The results of these studies suggest that PGs may be closely related to many kinds of tumors.…”
Section: Introductionmentioning
confidence: 99%