If the signal goes through all of the brain, the person may shake all over, fall and lose consciousness [2]. Epilepsy (also known as a 'seizure disorder') is a chronic neurological disorder characterized by recurring seizures [3]. A seizure occurs when the message delivery system becomes unbalanced and when there is not enough gamma amino butyric acid (GABA), seizure is occur because of receiving neurons is flooded with signals [4]. Seizures are induced by the influx of sodium and calcium ions mediated by excitatory neurotransmitters such as aspartate and glutamate and also Seizure inhibition is mediated by chloride ions entry and potassium ion outflow mediated by GABAergic neurotransmitter [5] (Figure 1). The seizure causes that divided into two type generalized and partial include high fever, especially in infants, drug use, metabolic disturbances, head trauma, e.g., car accident, brain tumor, infection(meningitis), stroke, Genetic factor and complication of diabetes or pregnancy [6]. The characteristics of seizure are vary greatly and some known characteristics include; uncontrolled movements such as shaking of arms or legs, loss of consciousness, falling, staring into space (absences) mostly in children, appearing dazed, confusing and mumbling [7]. Intractability defined by Berg., et al. as failure of two appropriate anti-epilepsy drugs