Case report of adult T-cell lymphoma/leukemia

Junior, Lacy Cardoso de Brito; Rocha, Euzamar Gaby; Santos, Sérgio Antônio Batista dos; Francês, Larissa Tatiane Martins

doi:10.1590/s1676-24442013000100007

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Finally, 90 articles were chosen including 940 ATL reported cases; 24 papers were found in the Caribbean, 15,24,25,28–48 two in Central America (Table 2) 49,50 and 64 in South America (Table 3). 9,16,51…”

Section: Resultsmentioning

confidence: 99%

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Adult T-cell leukemia/lymphoma in South and Central America and the Caribbean: systematic search and review

2016

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Adult T-cell leukemia/lymphoma (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-1) which is endemic in countries of Caribbean and Central and South America. We performed a systematic search and review to identify publications on ATL in these countries to verify if this disease was getting recognition in these regions as well as the characteristics of the observed cases. The median age of 49.4 years was lower than that referred to in Japan. According to our findings in most Brazilian states and in some other countries, ATL is not being recognized and should be strongly considered in the differential diagnosis of T-cell leukemias/lymphomas. Failure to identify these cases may be due to the unsystematic realization of serology for HTLV-1 and phenotypic identification of non-Hodgkin lymphomas that may result from lack of resources. Detection of ATL cases has been more feasible with cooperation from foreign research centers. A huge effort should be made to improve the surveillance system for ATL diagnosis in most of the South- and Central-American and Caribbean countries, and this attitude should be embraced by public organs to support health professionals in this important task.

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Section: Resultsmentioning

confidence: 99%

“…In this study, the analysis of cases was taken by birthplace, and there were patients from various other states, mainly from Minas Gerais, Paraíba, Ceará and Pará. However, only one ATL case report was found in Pará 81 and no published case in Maranhão, highly endemic HTLV-1 Brazilian states. 4…”

Section: Commentsmentioning

confidence: 99%

Adult T-cell leukemia/lymphoma in South and Central America and the Caribbean: systematic search and review

2016

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“…In Brazil, the highest concentrations of HTLV‐1 infection are located in regions such as Bahia, Pernambuco, and Pará. HTLV‐1/2 are present in all regions but with a low prevalence in the general population …”

Section: Introductionmentioning

confidence: 99%

Dermatological manifestations in patients with human T‐cell lymphotropic virus at a reference service in Amazon

et al. 2019

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Introduction Individuals infected with the human T‐cell lymphotropic virus type 1 (HTLV‐1) commonly present skin lesions, which may be a warning sign for the diagnosis of infection. This study describes the most prevalent skin manifestations in HTLV carriers attended at the clinic of Núcleo de Medicina Tropical (NMT) of the Universidade Federal do Pará (UFPA) in Belém, Pará, Brazil. Methods This is a study of a series of cases of patients infected with human T‐cell lymphotropic virus types 1 and 2 (HTLV‐1/2) treated at NMT UFPA between 1999 and 2016. A descriptive analysis of data was applied. Results Among 788 surveyed medical records in the service, 15.10% (n = 119) were referred to the dermatology clinic. From the series of cases that presented with skin lesions, 66.39% were female and 33.61% were male, and the average age of this group was 48 years. There was a predominance of patients with noninfectious inflammatory manifestations (64.2%), followed by infectious ones (24.6%), and 1.58% with lymphoproliferative diseases. As for the group of lesions, 45.26% of the erythematous‐squamous type were observed, followed by dyschromia (24.21%), and eczematous (14.74%). One patient with a diagnosis of adult T‐cell leukemia/lymphoma, another with parapsoriasis, and four with infective dermatitis are highlighted. Conclusion Skin disorders in the HLTV positive patient are important causes of referral to the dermatologist with etiological and skin lesions groups diversity. In the series of cases studied, lymphoproliferatives diseases and infective dermatitis associated with HTLV‐1 were presented as a challenge for the diagnosis and clinical management of these patients.

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New insight into 20(S)-ginsenoside Rh2 against T-cell acute lymphoblastic leukemia associated with the gut microbiota and the immune system

Xia

Zhang

et al. 2020

European Journal of Medicinal Chemistry

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Case report of adult T-cell lymphoma/leukemia

Cited by 3 publications

References 14 publications

Adult T-cell leukemia/lymphoma in South and Central America and the Caribbean: systematic search and review

Adult T-cell leukemia/lymphoma in South and Central America and the Caribbean: systematic search and review

Dermatological manifestations in patients with human T‐cell lymphotropic virus at a reference service in Amazon

New insight into 20(S)-ginsenoside Rh2 against T-cell acute lymphoblastic leukemia associated with the gut microbiota and the immune system

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