Carcinoma gástrico: análise sistemática de 289 gastrectomias consecutivas em Belo Horizonte (MG)

Lemes, Laura A.O.; Neunschwander, Letícia C.; Matta, Lincoln A.C.; Filho, José; Soares, Paula; Cabral, Mônica Maria Demas Álvares; Nogueira, Ana Margarida Miguel Ferreira; Rodrigues, Marco Antônio Gonçalves

doi:10.1590/s1676-24442003000100012

Cited by 5 publications

(12 citation statements)

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“…With respect to histological type, adenocarcinoma was the predominant type. Adenocarcinoma has also been the predominant type in other studies (4,16,22,30) . Other histological types included stromal tumors, lymphomas and carcinoid tumors, which corresponded to a minority of cases (4.6%).…”

Section: Discussionsupporting

confidence: 51%

“…Thus, in most cases the diagnosis is made in an advanced stage of the disease, a fact compromising the efficacy of therapeutic procedures and worsening the prognosis of the patients (16,22,24,34) . The most common histological type of gastric cancer is adenocarcinoma, which accounts for 90% to 95% of cases of this cancer (17) .…”

Section: Case Study Of Stomach Adenocarcinoma Conducted At a Cancer Rmentioning

confidence: 99%

“…According to the Lauren classification (15) , adenocarcinoma can be divided into the intestinal and diffuse type. The intestinal type predominates in high-risk areas and arises from precursor lesions, whereas the diffuse type shows a similar distribution in high-and low-risk areas and no precursor lesions are identified (16,19) . Considering the high prevalence of stomach cancer in the State of Pará, the objective of the present study was to evaluate the clinical, macroscopic and histopathological characteristics of stomach adenocarcinoma in patients seen at the Ofir Loiola Hospital, the only public hospital in the state that offers specialized cancer treatment, in order to gather information about the current incidence and characteristics of this cancer that could contribute to an early diagnosis.…”

Section: Case Study Of Stomach Adenocarcinoma Conducted At a Cancer Rmentioning

confidence: 99%

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Case study of stomach adenocarcinoma conducted at a cancer referral hospital in northern Brazil

Vinagre

Campos

Sousa

2012

Arq. Gastroenterol.

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-Context -Stomach cancer is the second leading cause of death due to cancer in the world and the incidence of this disease continues to be high in Brazil. In the Northern region, gastric cancer is the second most frequent cancer among men and the third among women. In the State of Pará, stomach adenocarcinoma is a public health problem since mortality rates are above the Brazilian average. Objective -To analyze the clinical and anatomopathological profile of stomach adenocarcinoma in patients seen at Ofir Loiola Hospital. Methods -In a retrospective study, records from 302 patients with gastric cancer undergoing surgery between 2006 and 2008 were analyzed. Data regarding patient profile, early symptoms, alterations upon physical examination, type of surgery, and macroscopic and histological findings were obtained from the records. Results -Most patients (63.9%) were men, 48% were older than 60 years, 50.9% were from the metropolitan region of Belém, 68.2% presented epigastric pain as an early symptom, and abdominal tenderness upon palpation was observed in 63.7%. The antrum was the most affected anatomical site (62.1%), followed by the gastric body (26.9%). Borrmann III (ulcerated-infiltrative) was the predominant endoscopic type. Adenocarcinoma accounted for 95.4% of all cases, including the intestinal type in 56.6% and the diffuse type in 41.3%. Most patients had stage IIIB and IV tumors and total gastrectomy was the most frequent type of surgery (37.4%). Conclusion -The present study demonstrated that gastric adenocarcinoma mainly affected men over the age of 60 who were from the metropolitan region of Belém. Most adenocarcinomas were in an advanced stage at the time of diagnosis, a fact requiring more aggressive surgical resection in these cases. These data highlight the urgent need for the implementation of preventive measures and early detection programs of gastric cancer. HEADINGS -Stomach neoplasms. Adenocarcinoma.

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Section: Discussionsupporting

confidence: 51%

Section: Case Study Of Stomach Adenocarcinoma Conducted At a Cancer Rmentioning

confidence: 99%

Section: Case Study Of Stomach Adenocarcinoma Conducted At a Cancer Rmentioning

confidence: 99%

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Case study of stomach adenocarcinoma conducted at a cancer referral hospital in northern Brazil

Vinagre

Campos

Sousa

2012

Arq. Gastroenterol.

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“…All samples were processed and analyzed at the APM, according to the anatomopathologic protocol (18) , which comprises macroscopic and microscopic evaluation of the tumor, including tumor measures, macroscopic Borrmann type (2) , location, histological type according to Laurén's classification (17) and the World Health Organization (WHO) (35) , growth pattern described by Ming (22) , presence of lymphatic vascular invasion (LVI), blood vascular invasion (BVI), and anatomopathological TNM staging (5) .…”

Section: Methodsmentioning

confidence: 99%

“…(18) GC: gastric cancer; pm: proximal margin; dm: distal margin; muc: mucosa. Significant samples of tumor, of adjacent mucosa (three to six pieces), of the proximal and distal margins of surgical resection, matching with the greater and lesser curvatures, of the gastric mucosa of the antrum, the body and the angular notch, as well as all dissected LNs, were subjected to histological examination.…”

Section: Methodsmentioning

confidence: 99%

Impact of using a lymph node revealing solution in surgical specimens for pathological staging of gastric cancer

Sousa¹,

Savassi-Rocha²,

Cabral³

2014

Jornal Brasileiro De Patologia E Medicina Laboratorial

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Introduction: Lymph node (LN) metastasis is a major staging criterion of gastric cancer (GC). GC prognosis is associated with the number of metastatic LNs. Objective: To evaluate the impact of using a lymph node revealing solution (LRS) in gastrectomy specimens. Material and methods: prospective study in 30 gastrectomy specimens (19 men, average age of 59.5; 11 women, average age of 66.1) for pathological tumor, node, metastasis (TNM) staging. After LN dissection according to the routine procedures (conventional method [CM]), the tissue was emerged in LRS: a mixture containing 65% ethanol, 20% ether, 5% acetic acid, and 10% formalin solution (10%), for 36 hours with 3 changes. A new LN dissection was performed. The number of LNs obtained from both methods was compared and analyzed. The number of metastatic and non-metastatic LNs was determined. Results: From 1,005 (33.5/specimen) dissected LNs, 657 of which (21.9/specimen) by the CM, and 348 (11.6/specimen) after using LRS (p = 0.0002), metastases were detected in 272 LNs (9.2/case), 211 of which (7.0/specimen) were found with the CM, and 61 (2.0/specimen) after using LRS (p = 0.0028). The number of LNs increased 53.0% with LRS, and the number of metastatic LNs was 28.9% higher. The pN classification changed in 5 (16.7%) of the 30 specimens, and in stage grouping in 4 (13.3%) analyzed cases. Conclusion: The use of LRS in gastrectomy specimens is simple, enables dissection, increases the number of LNs, and occasionally changes pN staging and stage grouping.

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The presence of metastases in regional lymph nodes is associated with tumor size and depth of invasion in sporadic gastric adenocarcinoma

Cambruzzi

Azeredo

Kronhart

et al. 2014

ABCD, arq. bras. cir. dig.

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BackgroundGastric adenocarcinoma is more often found in men over 50 years in the form of an antral lesion. The tumor has heterogeneous histopathologic features and a poor prognosis (median survival of 15% in five years).AimTo estimate the relationship between the presence of nodal metastasis and other prognostic factors in sporadic gastric adenocarcinoma.MethodWere evaluated 164 consecutive cases of gastric adenocarcinoma previously undergone gastrectomy (partial or total), without clinical evidence of distant metastasis, and determined the following variables: topography of the lesion, tumor size, Borrmann macroscopic configuration, histological grade, early or advanced lesions, Lauren histological subtype, presence of signet ring cell, degree of invasion, perigastric lymph node status, angiolymphatic/perineural invasion, and staging.ResultsWere found 21 early lesions (12.8%) and 143 advanced lesions (87.2%), with a predominance of lesions classified as T3 (n=99/60, 4%) and N1 (n=62/37, 8%). The nodal status was associated with depth of invasion (p<0.001) and tumor size (p<0.001). The staging was related to age (p=0.048), histological grade (p=0.003), and presence of signet ring cells (p = 0.007), angiolymphatic invasion (p = 0.001), and perineural invasion (p=0.003).ConclusionIn gastric cancer, lymph node involvement, tumor size and depth of invasion are histopathological data associated with the pattern of growth/tumor spread, suggesting that a wide dissection of perigastric lymph nodes is a fundamental step in the surgical treatment of these patients.

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Carcinoma gástrico: análise sistemática de 289 gastrectomias consecutivas em Belo Horizonte (MG)

Cited by 5 publications

References 20 publications

Case study of stomach adenocarcinoma conducted at a cancer referral hospital in northern Brazil

Case study of stomach adenocarcinoma conducted at a cancer referral hospital in northern Brazil

Impact of using a lymph node revealing solution in surgical specimens for pathological staging of gastric cancer

The presence of metastases in regional lymph nodes is associated with tumor size and depth of invasion in sporadic gastric adenocarcinoma

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