Screening of Brazilian plants for antimicrobial and dnadamaging activities: I. Atlantic rain forest . Ecological station juréia-itatins

Agripino, Debora G.; Lima, Marcos Enoque Leite; Silva, Marcelo Rogério da; Meda, Cristiane Infante; Bolzani, Vanderlan S.; Cordeiro, Inês; Young, Maria Cláudia Marx; Moreno, Paulo Roberto Hrihorowitsch

doi:10.1590/s1676-06032004000200009

Cited by 21 publications

(19 citation statements)

References 29 publications

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“…These data corroborate a previous study showing that the ethanol extract of stems is able to reduce DNA damage in Saccharomyces cerevisiae (Agripino et al, 2004).…”

Section: Resultssupporting

confidence: 92%

“…Pharmacological studies with some species of the Marcgraviaceae family indicate antifungal (Jones et al, 2000) and anxiolytic activities (Mullally et al, 2011). Studies investigating the medicinal potential of S. brasiliensis also reported antibacterial activities (Mello et al, 2014), and Agripino et al (2004) showed that ethanol extracts of stems of S. brasiliensis could protect against DNA damage. In folk medicine, S. brasiliensis tea is used to prevent heart disease (Agra, 2008), but no scientific studies have shown either efficacy or safety.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the genotoxic and antigenotoxic potential of crude extracts and fractions of Schwartzia brasiliensis (Choisy) Bedell ex Giraldo-Caas

S¹,

Mattos²,

F³

et al. 2015

J. Med. Plants Res.

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Schwartzia brasiliensis (Marcgraviaceae) is a native Brazilian shrub species with neotropical distribution in shoal environments. Recent studies have revealed its medicinal potential for some human diseases; therefore, this study aimed to evaluate the genotoxic and antigenotoxic potential of extracts and fractions obtained from different organs of S. brasiliensis. To accomplish this, plant extracts at different concentrations (25, 125 and 250 µg/ml) were incubated with plasmid DNA, either alone, or in the presence of stannous chloride as a positive control. Samples were then examined to detect any plasmid strand breaks or the absence of such breaks, which would indicate protection of these molecules against stannous chloride-induced lesions. Methanol and aqueous extracts of leaves and stems showed the ability to withstand the effects of stannous chloride in that no DNA damage was observed. Moreover, no other extracts or fractions used in the experimental conditions assayed resulted in DNA damage. These findings suggest that S. brasiliensis has antigenotoxic properties, indicating, in turn, that its biological activities deserve further study given the medicinal relevance of this plant.

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“…These data corroborate a previous study showing that the ethanol extract of stems is able to reduce DNA damage in Saccharomyces cerevisiae (Agripino et al, 2004).…”

Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Assessment of the genotoxic and antigenotoxic potential of crude extracts and fractions of Schwartzia brasiliensis (Choisy) Bedell ex Giraldo-Caas

S¹,

Mattos²,

F³

et al. 2015

J. Med. Plants Res.

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“…Pouteria psamophila was active against Cladosporium cladosporioides, but inactive against C. sphaerospermum, E. coli, S. aureus and Candida albicans. On the other hand, P. grandiflora presented a weak activity against C. sphaerospermum, and was inactive against C. cladosporioides, E. coli, S. aureus and C. albicans (Agripino et al, 2004). The dichloromethane extract from Pouteria reticulata (Engler) Eyma barks presented a weak activity against Mycobacterium tuberculosis (Graham et al, 2003) …”

Section: Antibacterial and Antifungal Activitiesmentioning

confidence: 99%

Genus Pouteria: chemistry and biological activity

Silva¹,

Simeoni²,

Silveira³

2009

Rev. bras. farmacogn.

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RESUMO: "Gênero Pouteria: Química e atividade biológica". O gênero Pouteria pertence à família Sapotaceae e pode ser encontrado em muitos continentes. As plantas desse gênero têm sido utilizadas na construção civil, na alimentação e também na medicina popular. Algumas atividades biológicas são reportadas às espécies desse gênero, tais como, antioxidante, anti-inflamatória, antibacteriana e antifúngica, mas seu real potencial como fonte de novos fármacos ainda é pouco conhecido. Assim, uma revisão sobre a composição química e as atividades biológicas de Pouteria é apresentada, com o intuito de estimular a continuação dos estudos das espécies aqui citadas, e a investigação de outras espécies para as quais não foram encontrados relatos.Unitermos: Pouteria, Sapotaceae, triterpenos, flavonoides, plantas medicinais. ABSTRACT:The genus Pouteria belongs to the family Sapotaceae and can be widely found around the World. These plants have been used as building material, as food, because the eatable fruits, as well as remedies in folk medicine. Some biological activities have been reported to species of this genus such as antioxidant, anti-inflammatory, antibacterial and antifungal. However, the real potential of this genus as source of new drugs or phytomedicines remains unknown. Therefore, a review of the so far known chemical composition and biological activities of this genus is presented to stimulate new studies about the species already reported moreover that species have no reference about chemistry or biological activities could be found until now.

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“…De A. nitidum já são conhecidos pelo menos treze estruturas de alcalóides indólicos, merecendo destaque a aspidospermina (1), quebrachamina (5), e ioimbina (2), muito comuns em outros representantes do gênero, e na sua maioria presentes nas cascas, folhas e galhos (Marques et al, 1996). Do total de 114 extratos de 88 espécies de plantas diferentes ocorrentes na Mata Atlântica no estado de São Paulo, somente os extratos de folhas e cascas do caule de A. ramiflorum (guatambu) mostraram atividade antibacteriana contra E. coli (Agripino et al, 2004). Com o objetivo de se descobrir drogas menos tóxicas para o tratamento da leishmaniose, extratos de plantas brasileiras bioprodutoras de alcalóides vêm sendo avaliados (Oliveira et al, 2002).…”

Section: Etnofarmacologia Atividade Biológica E Alcalóides Indólicosunclassified

Atividade biológica e alcalóides indólicos do gênero Aspidosperma (Apocynaceae): uma revisão

Oliveira

Freitas

Mathias

et al. 2009

Rev. bras. plantas med.

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Atividade biológica e alcalóides indólicos do gênero Aspidosperma (Apocynaceae): uma revisão RESUMO:Embora sejam conhecidas principalmente como fonte de madeira nobre para aplicação na construção de móveis, as espécies do gênero Aspidosperma apresentam muitos estudos na área da fitoquímica e poucos estudos na área da farmacologia. As espécies do gênero Aspidosperma são largamente aplicadas por populares como potenciais agentes antimaláricos, no tratamento da leishmaniose, de inflamações do útero e ovário, como anticonceptiva, em diabetes e em problemas estomacais, contra câncer, febre e reumatismo. Do ponto de vista químico, a grande maioria das espécies constituintes do gênero já foi submetida a algum estudo de isolamento e identificação dos alcalóides indólicos presentes nas mais diversas partes das plantas. Já do ponto de vista farmacológico poucos testes foram realizados até então para justificar a grande aplicação das mesmas por populares e a importância dos alcalóides indólicos presentes nas representantes do gênero. Visando contribuir para um maior conhecimento sobre a importância da presença dos alcalóides indólicos no gênero Aspidosperma e sua relação com as atividades farmacológicas atribuídas ou testadas, é que apresentamos uma revisão das principais publicações envolvendo estudos químicos e biológicos do gênero Aspidosperma. Palavras-chave: Aspidosperma, alcalóides indólicos, atividade biológica, etnofarmacologiaABSTRACT: Biological activity and indole alkaloids of the genus Aspidosperma (Apocynaceae): a review. Although mainly known as source of noble wood for furniture construction, species of the genus Aspidosperma have been extensively studied in Phytochemistry but scarcely investigated in Pharmacology. Aspidosperma species have been commonly used in folk medicine as potential antimalarial agents; in the treatment of leishmaniasis, and uterus and ovary inflammations; as contraceptive; in diabetes and stomach disorders; and against cancer, fever and rheumatism. From a chemical point of view, the great majority of Aspidosperma species have already been subjected to isolation and identification of indole alkaloids present in their several parts. From a pharmacological point of view, few tests have been carried out so far to justify the great applicability of these species in folk medicine besides the importance of the indole alkaloids present in the genus representatives. Aimed at improving the knowledge on the importance of indole alkaloids in the genus Aspidosperma and their relationship with attributed or tested pharmacological activities, we present a review of the main reports involving chemical and biological studies on the genus Aspidosperma.

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Screening of Brazilian plants for antimicrobial and dnadamaging activities: I. Atlantic rain forest . Ecological station juréia-itatins

Cited by 21 publications

References 29 publications

Assessment of the genotoxic and antigenotoxic potential of crude extracts and fractions of Schwartzia brasiliensis (Choisy) Bedell ex Giraldo-Caas

Assessment of the genotoxic and antigenotoxic potential of crude extracts and fractions of Schwartzia brasiliensis (Choisy) Bedell ex Giraldo-Caas

Genus Pouteria: chemistry and biological activity

Atividade biológica e alcalóides indólicos do gênero Aspidosperma (Apocynaceae): uma revisão

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