2011
DOI: 10.1590/s1519-69842011000300020
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Abstract: This study aimed to contribute to our knowledge of the parasite-vector interaction associated with Trypanosoma cruzi (Chagas, 1909) infection in Panstrongylus megistus (Burmeister, 1835), an important vector of Chagas' disease in Brazil. The prevalence and intensity of T. cruzi infection, the incidence of metacyclogenesis and the frequency of nuclear phenotypes in Malpighian tubules were investigated in nymphs of P. megistus, reared at 28 °C and subjected to heat shock (40 °C, 1 hour) two days after infection … Show more

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Cited by 5 publications
(4 citation statements)
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References 43 publications
(56 reference statements)
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“…For instance, in NIH 3T3 mouse cells treated with valproic acid produce decondensation in the chromatin structure of the nucleus, including the heterochromatin areas (Felisbino et al, 2014); while in Malpighian tubule cells of the blood-sucking insect, Triatoma infestans, heterochromatin decondensation occurs either after treatments with heavy metals (copper and mercury) or heat shocks (Mello et al, 1995(Mello et al, , 2001). Moreover, heterochromatin decondensation after heat shock treatements in Malpighian tubule cells of a vector of Chagas' disease in Brazil, Panstrongylus megistus, infected and non-infected by Trypanosoma cruzi, has been also reported (Garcia et al, 2011). In our case we believe that such factors would not have affected the results obtained since the samples analysed are from laboratory cultures that were kept under standardised conditions of temperature and salinity.…”
Section: Discussionmentioning
confidence: 69%
“…For instance, in NIH 3T3 mouse cells treated with valproic acid produce decondensation in the chromatin structure of the nucleus, including the heterochromatin areas (Felisbino et al, 2014); while in Malpighian tubule cells of the blood-sucking insect, Triatoma infestans, heterochromatin decondensation occurs either after treatments with heavy metals (copper and mercury) or heat shocks (Mello et al, 1995(Mello et al, , 2001). Moreover, heterochromatin decondensation after heat shock treatements in Malpighian tubule cells of a vector of Chagas' disease in Brazil, Panstrongylus megistus, infected and non-infected by Trypanosoma cruzi, has been also reported (Garcia et al, 2011). In our case we believe that such factors would not have affected the results obtained since the samples analysed are from laboratory cultures that were kept under standardised conditions of temperature and salinity.…”
Section: Discussionmentioning
confidence: 69%
“…In fact, metacyclic trypomastigotes, the infective form, show increased levels of HSP70, HSP60 and HSP90 when compared to epimastigotes (Paba et al 2004 ), although it is still unclear whether HSP induction is part of the differentiation process or is just an adaptation to the new environment (Folgueira and Requena 2007 ). However, elevated temperatures inhibit metacyclogenesis in infected insects but do not affect parasite survival (Garcia et al 2011 ). These results suggest that any preparedness to higher temperatures is restricted to the metacyclic trypomastigote.…”
Section: Heat Stress In T Cruzimentioning
confidence: 99%
“…The clinical aspects of Chagas disease, the biology, morphology and behavior of Trypanosoma cruzi, are the focus of several studies, since variations in the structures involved in parasitism of the vertebrate host have been recorded (Vallejo et al, 1988;Garcia et al, 2011). However, one of the major ways of preventing new CD cases from being acquired is to control the vector, because the elimination of triatominae in households and surroundings decreases the chances these insects have to reach human blood (Silveira and Rezende, 1994).…”
Section: Introductionmentioning
confidence: 99%