Cytotoxic and antifungal properties of medicinal plants from Ceará, Brazil

Background:Many medicinal plant species from the Araripe Basin are widely known and used in folk medicine and for commercial manufacturing of phytotherapeutic products. Few ethnobotanical and pharmacological studies have been undertaken in this region, however, in spite of the great cultural and biological diversity found there.Materials and Methods:Extracts of 11 plant species collected from Ceará state, Brazil, were subjected to the brine shrimp lethality test in order to detect potential sources of novel cytotoxic, antitumor compounds. The larvicidal activity, based on the percentage of larval mortality, was evaluated after 24 h exposure to the treatments. Results:All species tested showed good larvicidal activity as compared to a reference compound and literature data. The extract from Vanillosmopsis arborea was the most active with an LC50 of 3.9 μg/ml. Best results were shown by Lantana montevidensis against Pseudomonas aeruginosa [minimum inhibitory concentration (MIC) 8μg/ml] and Escherichia coli (MIC 32 μg/ml), Zanthoxylum rhoifolium against E. coli (MIC, 256 μg/ml) and Staphylococcus aureus (MIC 64 μg/ml) and Croton zenhtneri against S. aureus (MIC 64 μg/ml).Conclusion:Chemical tests indicated that a wide variety of natural product classes was present in those extracts that showed significant activities in the bioassays.

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“…The cytotoxicity and antitumoral effects, such as those produced by antifungal activity of extracts from Ceará’s flora, have been reported. [3]…”

Section: Introductionmentioning

confidence: 99%

Biological screening of araripe basin medicinal plants using Artemia salina Leach and pathogenic bacteria

et al. 2010

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“…These suggest that the plant leaves may not be as toxic as the seeds. J curcas leaves possess antiseptic, purgative, cicatrizant effects (Faria et al, 2006). Phytochemical analysis of J curcas revealed the presence of alkaloids, glycosides, saponins, tannins, flavonoids, resins, sterols, terpenoids and carbohydrates in the methanol extract that have implicated in the antimicrobial activities as well as free radical scavenging activities of some plants.…”

mentioning

confidence: 99%

Antifungal and Antimicrobial Activity of Crude Methanolic Extract and Its Fractions of Jatropha Curcas L., Leaves

2011

Assiut Veterinary Medical Journal

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In this paper the polyphenolic compounds of methanolic extract of Jatropha curcas leaves have been investigated. The analytical procedures revealed 7 flavonoid compounds: biapigenin-(8,8″)-methylene-6,6″-di-Cβ-D-glucopyranoside (1), apigenin-7-O-β-D-neohesperidoside (2), apigenin 7-O-β-D-galactoside (3), orientin (4), apigenin (5), isovitexin (6) and vitexin (7). The crude methanol extract and the 7 purified compounds were tested against fungi Botrytis cinerea, Rhizoctonia solani, Sclerotinia sclerotiorum and Fusarium solani. The crude extracts absolutely inhibit the fungi growth. On the other hand, vitexin was similar to crude extract as well. The other compounds were moderate in their antifungal effects in comparison to control ones. In-vitro antimicrobial activity of the methanolic leaves extract was carried out by using the agar-well diffusion method on Gram-positive bacteria Staphylococcus aureus. The Gramnegative included Escherichia coli was compared with standard drug Streptomycin and Ampicillin.

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Chapter 2 Jatropha curcas

Carels

2009

Advances in Botanical Research

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Cytotoxic and antifungal properties of medicinal plants from Ceará, Brazil

Cited by 4 publications

References 6 publications

Biological screening of araripe basin medicinal plants using Artemia salina Leach and pathogenic bacteria

Biological screening of araripe basin medicinal plants using Artemia salina Leach and pathogenic bacteria

Antifungal and Antimicrobial Activity of Crude Methanolic Extract and Its Fractions of Jatropha Curcas L., Leaves

Chapter 2 Jatropha curcas

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