Evidence indicating participation of the serotonergic system in controlling feeding behavior in Coturnix japonica (Galliformes: Aves)

Reis, L. C.; Almeida, A C; Cedraz-Mercez, P.L.; Olivares, Emerson Lopes; Jr., A. Marinho; Thomaz, CM

doi:10.1590/s1519-69842005000200020

Cited by 11 publications

(8 citation statements)

References 23 publications

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“…Two investigation possibilities were undertaken: Firstly, 5-HT was administered by sc route in quails to evaluate behavioral reactions. Previous studies of our laboratory showed evidence of the central action of 5-HT systemically injected in the evaluation of its effect (and of their precursors) in the feeding behavior of quails (Reis et al, 2005). In such study, our group showed for the first time, a hypnogenic action induced by systemic serotonin.…”

Section: Introductionsupporting

confidence: 56%

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Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Galliformes; Aves)

Pa¹,

Ro²,

Pl³

et al. 2007

Braz. J. Biol.

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This study was carried out aiming to reach behavioral and neuropharmacological evidence of the permeability of the blood-brain barrier (BBB) to serotonin systemically administered in quails. Serotonin injected by a parenteral route (250-1000 µg.kg , sc) elicited a sequence of behavioral events concerned with a sleeping-like state. Sleeping-like behaviors began with feather bristling, rapid oral movements, blinking and finally crouching and closure of the eyes. Previous administration of 5-HT2C antagonist, LY53857 (3 mg.kg , sc) a 5-HT2A/2C/3 agonist induced intense hypomotility, long periods of yawning-like and sleeping-like states. Previous ketanserin suppressed gaping responses and reduced hypomotility, rapid oral movements and bristling but was ineffective for remaining responses induced by quipazine. Results showed that unlike mammals, serotonin permeates the BBB and activates hypnogenic mechanisms in quails. Studies using serotoninergic agonist and antagonists have disclosed that among the actions of the serotonin, feather bristling, rapid oral movements and yawning-like state originated from activation of 5-HT2 receptors while blinking and closure of the eyes possibly require other subtypes of receptors.Keywords: serotonin, blood brain barrier, hypnogenic action, sleep, yawning, quails.Evidências comportamentais e neurofarmacológicas de que a serotonina atravessa a barreira hematoencefálica em Coturnix japonica (Galliformes; Aves) ResumoEste estudo foi desenvolvido objetivando ampliar as evidências comportamentais e neurofarmacológicas da permeabilidade da barreira hematoencefálica (BHE) à serotonina administrada sistemicamente em codornas. A serotonina injetada por via parenteral (250-1000 µg.kg, sc) produziu uma seqüência de eventos relacionados com um estado semelhante ao sono. Comportamentos semelhantes ao sono começaram com o eriçamento das penas, movimentos orais rápidos, piscadelas e finalmente agachamento e fechamento dos olhos. A administração prévia do antagonista do receptor 5-HT2C, LY53857 (3 mg.kg -1 , sc) reduziu significativamente os episódios de eriçamento das penas e movimentos orais rápidos, mas não alterou a freqüência de piscadelas e fechamento dos olhos. Tratamento com o antagonista do receptor 5-HT2A/ 2C, quetanserina (3 mg.kg , sc), um agonista dos receptores 5-HT2A/2C/3, induziu intensa hipomotilidade e longos períodos de comportamentos semelhantes ao bocejo e ao sono. O tratamento prévio com quetanserina suprimiu as reações de bocejo e reduziu a hipomotilidade, os movimentos orais rápidos e as piscadelas, mas foi sem efeito para as demais respostas induzidas pela quipazina. Os resultados mostraram que, diferentemente dos mamíferos, a serotonina atravessa a BHE e ativa mecanismos hipnogênicos em codornas. Estudos com agonistas serotoninérgicos e antagonistas revelaram que, entre as ações da serotonina, o eriçamento das penas, os movimentos orais rápidos e o comportamento semelhante ao bocejo foram originados pela ativação de receptores 5-HT2, enquanto o piscar e o fechamento...

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Section: Introductionsupporting

confidence: 56%

“…In a previous study, we demonstrated for the first time that 5-HT administered peripherally permeates the BBB in quails (Reis et al, 2005). Behavioral and neuropharmacological evidence of this response was investigated in the present study.…”

Section: Discussionmentioning

confidence: 61%

Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Galliformes; Aves)

Pa¹,

Ro²,

Pl³

et al. 2007

Braz. J. Biol.

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“…4,5 Serotonin (5-hydroxytryptamine; 5-HT) is thought to play a key role in the suppression of appetite. [6][7][8] Clinical studies provide evidence that 5-HT is involved in the disturbances of eating disorders. 9 Hypothalamus is known to have an important role in the regulation of appetite by transducing satiety signals of 5-HT.…”

Section: Introductionmentioning

confidence: 99%

Long-term consumption of sugar-rich diet decreases the effectiveness of somatodendritic serotonin-1A receptors

Inam¹,

Jabeen²,

Haleem³

et al. 2008

Nutritional Neuroscience

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8-Hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT), a 5-hydroxytryptamine (5-HT)-1A selective agonist was used to investigate a possible role of somatodendritic serotonin-1A receptors in the precipitation of hyperphagia and decreases of 5-HT metabolism associated with long-term consumption of sugar rich-diet. In the first part of study, dose-related hyperphagic effects of 8-OH-DPAT were monitored in freely feeding rats. In the second part of study, rats were fed freely on a sugar-rich diet (prepared by mixing standard rodent diet with table sugar in the ratio of 3:1 [w/w]) for 5 weeks. Hyperphagic effects of 8-OH-DPAT were monitored in sugar-rich diet and normal diet treated rats by injecting the drug at a dose of 0.25 mg/kg body weight, a dose that produced significant hyperphagia. Effects of 8-OH-DPAT on decreasing 5-HT metabolism in the hypothalamus were also investigated in the two groups. Results showed that administration of 8-OH-DPAT at a dose of 0.25 mg/kg body weight elicited hyperphagia and decreased 5-HT metabolism in normal diet treated animals but the effects in sugar-rich diet treated animals were smaller and not significant suggesting a decrease in the effectiveness of somatodendritic 5-HT-1A receptors, which provide a feedback control over the synthesis and release of 5-HT in terminal region. A possible mechanism involved in sugar-diet induced decreases of 5-HT metabolism is discussed.

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“…This experimental maneuver is widely used to evaluate the brain serotonin production and subsequent increase of the serotoninergic transmission (Fernstrom, 1983;Badauê-Passos et al, 2003;Reis et al, 2005). TPO is considered the rate-limiting enzyme of the serotonin synthesis in serotoninergic neurons (Tyce, 1990;Boadle-Biber, 1993).…”

Section: Introductionmentioning

confidence: 99%

Nocturnal plasma levels of melatonin in quails (Coturnix japonica) injected with l-5-hydroxy-tryptophan

et al. 2007

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This study aimed to demonstrate the influence of the systemic administration of l-5-hydroxy-tryptophan (L-HTP) on the plasma levels of melatonin during the dark period in quails. Throughout daylight, the plasma levels of melatonin did not differ significantly, oscillating between 110.2 ± 15.8 pg.mL -1 and 157.4 ± 34.8 pg.mL , through the intracelomic route) administered at 18 hours lessened significantly the nocturnal increase of the plasma levels of melatonin (controls, 327.3 ± 20.1 and 315.8 ± 20.9 pg.mL -1 vs. 242.1 ± 24.8 and 217.5 ± 21 pg.mL -1 , respectively, at 20 and 24 hours, P < 0.05). The results obtained showed that the administration of L-HTP reduced the nocturnal melatonin release, possibly by bringing about an increase in serotonin synthesis and synaptic release in the pineal. Therefore, the serotoninergic transmission from the raphe towards the pineal would constitute a mechanism of modulation of the synthesis and melatonin release in quails.Keywords: melatonin, pineal, l-5-hydroxy-tryptophan, Coturnix japonica. Níveis plasmáticos noturnos de melatonina em codornas (Coturnix japonica) injetadas com l-5-hidroxi-triptofano ResumoEste trabalho objetivou demonstrar a influência da administração sistêmica de l-5-hidroxi-triptofano (L-HTP) sobre os níveis plasmáticos de melatonina durante o período noturno em codornas. Ao longo do período claro, os níveis plasmáticos de melatonina não diferiram significativamente, oscilando entre 110,2 ± 15,8 pg.mL -1 e 157,4 ± 34,8 pg.mL , respectivamente, às 20 e 24 horas, P < 0,05). Os resultados obtidos mostraram que a administração de L-HTP reduziu a liberação noturna de melatonina, possivelmente por suscitar um aumento da síntese e liberação sináptica de serotonina na pineal. Portanto, a transmissão serotoninérgica da rafe para a pineal constituiria um mecanismo de modulação da síntese e/ou liberação de melatonina em codornas.Palavras-chave: melatonina, pineal, l-5-hidroxi-triptofano, Coturnix japonica.

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Evidence indicating participation of the serotonergic system in controlling feeding behavior in Coturnix japonica (Galliformes: Aves)

Cited by 11 publications

References 23 publications

Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Galliformes; Aves)

Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Galliformes; Aves)

Long-term consumption of sugar-rich diet decreases the effectiveness of somatodendritic serotonin-1A receptors

Nocturnal plasma levels of melatonin in quails (Coturnix japonica) injected with l-5-hydroxy-tryptophan

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