Efeito da atividade física no osso normal e na prevenção e tratamento da osteoporose

Ocarino, Natália de Melo; Serákides, Rogéria

doi:10.1590/s1517-86922006000300011

Cited by 15 publications

(12 citation statements)

References 42 publications

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“…Whole body vibratory therapy may be indicated for immobilised patients to enhance mobility, muscle power and increase whole body BMD . The mechanism behind weight‐bearing to optimise bone health is due to mechanosensing factors which stimulate osteoblasts and other factors, to increase the total bone mineral content during mechanical loading …”

Section: Methodsmentioning

confidence: 99%

“…[4] The mechanism behind weight-bearing to optimise bone health is due to mechanosensing factors which stimulate osteoblasts and other factors, to increase the total bone mineral content during mechanical loading. [18,19] Oral or intravenous bisphosphonates have been used to treat osteoporosis and fractures in children with chronic diseases other than EB. Besides inconsistent results, a lack of evidence on their safety and efficacy in patients with EB means treatment for vertebral fractures in EB remains controversial.…”

Section: Determinants Related To Bone Health/osteoporosis Aetiologicamentioning

confidence: 99%

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Prevalence and pathogenesis of osteopenia and osteoporosis in epidermolysis bullosa: An evidence‐based review

Chen

Yang

Murrell

2018

Experimental Dermatology

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Background Osteopenia or osteoporosis is one of the many comorbidities in patients with Epidermolysis Bullosa (EB). Current literature on the prevalence of osteoporosis in EB is scarce. Objective This review will analyse the current literature in the field of patients with compromised bone health in EB and any articles on the prevalence of such diseases in EB groups. Methods A systematic search for articles related to bone health and epidermolysis bullosa (EB) (1946‐2017) was performed on seven databases: MEDLINE, EMBASE and EBM, PubMed, ProQuest, Scopus and Web of Science. Search terms: epidermolysis bullosa, osteop*, bone mass, bone mineral*, fracture, dual X‐ray absorptiometry, vitamin D, calcium, nutrition, exercise and physical activity. Abstracts from all search results were screened, and reference scanning of the search results was performed. Eighty‐three articles met the selection criteria and were considered for review. Letters to the editor and abstract‐only articles were excluded. Articles were favoured based on citation count, impact factor of their journal and study sample size. The search included all languages. Results The searches yielded a total of 1309 articles including 717 duplicates. The remaining 592 articles were screened by title and abstracts. Eighty‐three full‐text articles were analysed. Twenty‐one articles directly relating to bone health in EB were included. Three descriptive studies and one case‐control study were found, indicating a need for research of larger scale. Conclusion Further investigations into osteoporosis in EB, especially the milder forms of EB, are valuable in providing evidence to support guideline developments for EB bone health management.

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Section: Methodsmentioning

confidence: 99%

Section: Determinants Related To Bone Health/osteoporosis Aetiologicamentioning

confidence: 99%

Prevalence and pathogenesis of osteopenia and osteoporosis in epidermolysis bullosa: An evidence‐based review

Chen

Yang

Murrell

2018

Experimental Dermatology

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“…estiverem associados. Assim, alterações no metabolismo, na absorção de cálcio e no perfil hormonal, principalmente em mulheres após a menopausa, associadas à inatividade física, contribuem para um balanço negativo no equilíbrio da remodelação óssea, tendo a osteoporose como principal conseqüência 20 .…”

Section: Discussionunclassified

Nifedipina promove diminuição da qualidade óssea em ratas com osteopenia

Bertoncello

Silva²,

Borges³

2008

Fisioter. Pesqui.

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RESUMO: O objetivo do trabalho foi avaliar, por parâmetros biomecânicos e físicos, a qualidade óssea dos fêmures de ratas ovariectomizadas tratadas com nifedipina. Foram utilizadas 28 ratas Wistar, de 4 meses de idade, divididas nos grupos: intactas (Int); ovariectomizadas tratadas com salina (Ovx+Sal); ovariectomizadas tratadas com nifedipina (Ovx+Nfd), intactas tratadas com nifedipina (Int+Nfd). O tratamento durou oito semanas, seis dias por semana, com administração de nifedipina ou salina, por gavage, na dose de 10 mg e 0,1g/100g PC respectivamente. Tendo-se retirado o fêmur direito de cada animal, verificou-se a carga máxima suportada, a densidade mineral e a qualidade óssea. Os resultados foram analisados estatisticamente, com nível de significância fixado em p<0,05). Houve diminuição significativa da carga máxima dos fêmures dos animais tratados com nifedipina (grupos Ovx+Nfd e Int+Nfd). Nesse último grupo, houve aumento significativo da densidade mineral. Os resultados mostram que o tratamento com nifedipina promove pior qualidade óssea dos fêmures de ratas.ABSTRACT: The aim of this study was to assess, by biomechanical and physical parameters, the bone quality of femurs from ovariectomized female rats treated with nifedipine. Twenty eight Wistar female rats, 4 months old, were divided into four groups: intact (Int); intact treated with nifedipine (Int+Nfd); ovariectomized treated with saline (Ovx+Sal); ovariectomized treated with nifedipine (Ovx+Nfd). Treatment was carried out for eight weeks, six days per week, with administration of 10 mg of nifedipine or 0.1/100g BW of saline, by gavage. After removing the right femur of each animal, maximum load support, mineral density, and bone quality were assessed. Results were statistically analysed and significance level set at p<0.05. A significant reduction of maximal load support was found in femur of rats treated with nifedipine (Ovx+Nfd and Int+Nfd groups). In the latter group, a significant increase in mineral density was noticed. Results show that treatment with nifedipine resulted in lower bone quality.

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“…Estudos indicam que a atividade física está positivamente relacionada com a DMO, sendo um importante fator para sua manutenção (KEMMLER et al, 2002;MAIMOUN et al, 2003;OCARINO;SERAKIDES, 2006). Entre esses estudos, alguns utilizam o treinamento de força como intervenção, na tentativa de aumentar a DMO de indivíduos submetidos a esse tipo de atividade física (HUMPHRIES et al, 2000).…”

Section: Desenvolvimentounclassified

Os efeitos da atividade física na remodelação óssea

Soares

Filho

2017

J.Interdisc.Bio.

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Bone is a dynamic tissue, developed and adapted by hormones, cytokines and mechanical stimuli, such as physical activity. The bone undergoes changes, even after the end of skeletal growth, comprising the remodeling process, that is a balance between apposition and bone reabsorption. In this context, the maintenance of bone mineral density (BMD) is very important for the prevention of metabolic bone diseases, such as osteoporosis, which is characterized by a marked decrease in BMD. Studies indicate that physical activity is positively related to BMD, being an important factor for its maintenance. Among these studies, some use force training as an intervention, in an attempt to increase the BMD of individuals submitted to this type of physical activity. At the cellular level, the process of remodeling induced by overload in physical activity, seems to be performed by the action of osteocytes, which act as mechanical receptors of the applied stress, and release a chemical stimulating factor of the proliferation of osteoblasts in the stressed place. This study aimed to evaluate the effect of physical activity on bone remodeling. For this purpose, information was searched in the databases of CAPES, MEDLINE, LILACS and in the SciELO virtual library, selecting papers published in national and international periodicals between 1999 and 2016. The descriptors of subjects used were: "physical activity "," Bone remodeling "," bone mineral density ", using the intersection of sets. Although some results are contradictory, the literature does not question the beneficial effects of physical activity on bone tissue, both in healthy individuals, and in the prevention and treatment of Osteoporosis. The mechanisms by which physical activity stimulates osteoblastic differentiation from bone marrow stromal cells should be better elucidated so that more appropriate therapies can be developed and used in the treatment of individuals with some metabolic bone disease. K E Y W O R D SMotor activity, Bone remodeling, Bone density R E S U M OO osso é um tecido dinâmico, desenvolvido e adaptado por hormônios, citocinas e estímulos mecânicos, como a atividade física. Ele sofre alterações, mesmo após o final do crescimento do esqueleto, compreendendo o processo de remodelação, ou seja, um equilíbrio entre a posição e reabsorção óssea. Nesse contexto, a manutenção da densidade mineral óssea (DMO) é muito importante para a prevenção de doenças ósseas metabólicas, como a osteoporose, a qual é caracterizada por uma diminuição acentuada da DMO. Estudos indicam que a atividade física está positivamente relacionada com a DMO, sendo um importante fator para sua manutenção. Dentre estes estudos, alguns utilizam o treinamento de força como intervenção, na tentativa de aumentar a DMO de indivíduos submetidos a esse tipo de atividade física. Em nível celular, o processo de remodelação, induzido pela sobrecarga, como na atividade física, parece ser realizado pela ação dos osteócitos, que atuam como receptores mecânicos do estresse aplicado e liberam um fa...

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Efeito da atividade física no osso normal e na prevenção e tratamento da osteoporose

Cited by 15 publications

References 42 publications

Prevalence and pathogenesis of osteopenia and osteoporosis in epidermolysis bullosa: An evidence‐based review

Prevalence and pathogenesis of osteopenia and osteoporosis in epidermolysis bullosa: An evidence‐based review

Nifedipina promove diminuição da qualidade óssea em ratas com osteopenia

Os efeitos da atividade física na remodelação óssea

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