Seasonal variation on the presence of adenoviruses in stools from non-diarrheic patients

Vetter, Michele Regina; Staggemeier, Rodrigo; Vecchia, Andréia Dalla; Henzel, Andréia; Rigotto, Caroline; Spilki, Fernando Rosado

doi:10.1590/s1517-838246320140718

Cited by 12 publications

(7 citation statements)

References 17 publications

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“…This biennial pattern exhibited in rotavirus epidemiology is consistent with previous studies [39,40]. Similarly, adenovirus infection being mostly incidental during the months of July and August specifically (wherein the weather is usually hot due to Summer in Lebanon) has been reported in world literature in previous studies as well [41]. This variability might be owing to weather conditions which affect transmission of the viruses more rapidly.…”

Section: Discussionsupporting

confidence: 90%

Prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among Lebanese hospitalized children with acute gastroenteritis

Zaraket

Salami

Bahmad

et al. 2020

Heliyon

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Background: Acute gastroenteritis is a very common infectious disease facing all age groups worldwide, especially the pediatric population. Viruses, bacteria, and parasites are all possible causes of infectious gastroenteritis; however, viruses have become more frequently identified with the advances in the ability to diagnose viral infections, particularly rotavirus and adenovirus. We aimed in our study to compare between the prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among children with viral gastroenteritis in Lebanon. Materials and methods: A 12-months retrospective study was performed between January 1 st and December 31 st , 2018 including 308 children aged 1 month to 12 years, who were admitted to three tertiary healthcare centers in South Lebanon. Medical data were retrieved from patients' files, including clinical and laboratory information. Results: Rotavirus was found in stool of 204 patients (66.23 %), followed by adenovirus in 78 cases (25.32 %), and mixed group (rotavirus and adenovirus) in 26 cases (8.44%). The highest prevalence of rotavirus in our present study was seen among children between 12 and 23 months old, whereas patients infected with adenovirus were mainly aged between 24-35 months or 4-11 months. Majority of patients in the adenovirus and mixed groups had high-grade fever compared to the rotavirus group. Laboratory findings presented significantly higher average of white blood cells (WBCs), absolute neutrophil count (ANC), and C-reactive protein (CRP) in the mixed group compared to the two other groups. Monthly distribution of rotavirus and adenovirus infection revealed a biennial pattern of rotavirus incidence during January and July-August while frequency of adenovirus infection was highest during July-August. Conclusion: Due to the high prevalence of viral diarrhea among the pediatric age group in our region, particularly rotavirus and adenovirus, along with the associated non-specific signs and symptoms, we highly recommend that medical laboratories be equipped for virus detection. Also, vaccination against rotavirus should be considered as a prevention strategy.

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Section: Discussionsupporting

confidence: 90%

Prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among Lebanese hospitalized children with acute gastroenteritis

Zaraket

Salami

Bahmad

et al. 2020

Heliyon

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“…RVA and adenovirus appeared to peak in the dry months while norovirus GII and sapovirus peaked in the rainy season. Similar patterns in the seasonality of RVA, adenovirus, norovirus GII and sapovirus have been observed elsewhere [ 22 , 23 , 24 , 25 ]. The seasonality of astrovirus is not well described.…”

Section: Discussionsupporting

confidence: 77%

Epidemiological Trends of Five Common Diarrhea-Associated Enteric Viruses Pre- and Post-Rotavirus Vaccine Introduction in Coastal Kenya

et al. 2020

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Using real-time RT-PCR, we screened stool samples from children aged <5 years presenting with diarrhea and admitted to Kilifi County Hospital, coastal Kenya, pre- (2003 and 2013) and post-rotavirus vaccine introduction (2016 and 2019) for five viruses, namely rotavirus group A (RVA), norovirus GII, adenovirus, astrovirus and sapovirus. Of the 984 samples analyzed, at least one virus was detected in 401 (40.8%) patients. Post rotavirus vaccine introduction, the prevalence of RVA decreased (23.3% vs. 13.8%, p < 0.001) while that of norovirus GII increased (6.6% vs. 10.9%, p = 0.023). The prevalence of adenovirus, astrovirus and sapovirus remained statistically unchanged between the two periods: 9.9% vs. 14.2%, 2.4% vs. 3.2 %, 4.6% vs. 2.6%, (p = 0.053, 0.585 and 0.133), respectively. The median age of diarrhea cases was higher post vaccine introduction (12.5 months, interquartile range (IQR): 7.9–21 vs. 11.2 months pre-introduction, IQR: 6.8–16.5, p < 0.001). In this setting, RVA and adenovirus cases peaked in the dry months while norovirus GII and sapovirus peaked in the rainy season. Astrovirus did not display clear seasonality. In conclusion, following rotavirus vaccine introduction, we found a significant reduction in the prevalence of RVA in coastal Kenya but an increase in norovirus GII prevalence in hospitalized children.

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“…The core virome profiles observed in our work are consistent with previous studies, which detected Herpesviridae, Papillomaviridae, Adenoviridae and Anelloviridae within faecal samples from healthy individuals (Wylie et al ., ; Di Bonito et al ., ; Vetter et al ., ), underscoring the notion that virus interactions with the host cannot be solely envisioned as pathogenic (Virgin, ). We hypothesize that these viruses are found in the faeces mainly as a result of mucosal and epithelial exfoliation.…”

Section: Discussionmentioning

confidence: 95%

Characterization of the human DNA gut virome across populations with different subsistence strategies and geographical origin

Rampelli

Turroni

Schnorr

et al. 2017

Environmental Microbiology

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It is a matter of fact that the human gut microbiome also includes a non-bacterial fraction represented by eukaryotic cells and viruses. To further explore the gut microbiome variation in human populations, here we characterized the human DNA viral community from publicly available gut metagenome data sets from human populations with different geographical origin and lifestyle. In particular, such data sets encompass microbiome information from two western urban societies (USA and Italy), as well as two traditional hunter-gatherer communities (the Hadza from Tanzania and Matses from Peru) and one pre-agricultural tribe (Tunapuco from Peru). Our results allowed for the first taxonomic reconstruction of the complex viral metacommunities within the human gut. The core virome structure included herpesviruses, papillomaviruses, polyomaviruses, adenoviruses and anelloviruses. Using Random Forests and a co-occurrence analysis approach, we identified the viruses that distinguished populations according to their geographical origin and/or lifestyle. This paves the way for new research aimed at investigating the biological role of the gut virome in human physiology, and the importance of our viral counterpart in the microbiome-host co-evolutionary process.

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Seasonal variation on the presence of adenoviruses in stools from non-diarrheic patients

Cited by 12 publications

References 17 publications

Prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among Lebanese hospitalized children with acute gastroenteritis

Prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among Lebanese hospitalized children with acute gastroenteritis

Epidemiological Trends of Five Common Diarrhea-Associated Enteric Viruses Pre- and Post-Rotavirus Vaccine Introduction in Coastal Kenya

Characterization of the human DNA gut virome across populations with different subsistence strategies and geographical origin

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