2015
DOI: 10.1590/s1517-838246320140138
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Abstract: Klebsiella pneumoniae is an important cause of healthcare-associated infections worldwide. Selective pressure, the extensive use of antibiotics, and the conjugational transmission of antibiotic resistance genes across bacterial species and genera facilitate the emergence of multidrug-resistant (MDR) K. pneumoniae. Here, we examined the occurrence, phenotypes and genetic features of MDR K. pneumoniae isolated from patients in intensive care units (ICUs) at the First Affiliated Hospital of Xiamen University in X… Show more

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Cited by 44 publications
(35 citation statements)
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“…To date, infections caused by MDR K. pneumoniae have become a major challenge for treatment, resulting in increased mortality rates and excessive costs for patients [30]. MDR was observed in about 24% of the isolates that was lower than studies in Nepal [31], Ethiopia [29], and China [32].…”
Section: Discussionmentioning
confidence: 85%
“…To date, infections caused by MDR K. pneumoniae have become a major challenge for treatment, resulting in increased mortality rates and excessive costs for patients [30]. MDR was observed in about 24% of the isolates that was lower than studies in Nepal [31], Ethiopia [29], and China [32].…”
Section: Discussionmentioning
confidence: 85%
“…Anago et al (11) also reported a high presence of bla-Tem in Escherichia coli strains isolated from nosocomial infections in Southern Benin. Hou et al (31) reported high proportions of bla-SHV in Klebsiella pneumoniae strains compared to bla-Tem in China. The natural production of penicillinase by Klebsiella pneumoniae strains encoding a gene with SHV, LEN, and OKP variants explains the presence of SHV in Klebsiella pneumoniae strains (32).…”
Section: Discussionmentioning
confidence: 99%
“…Los genes casete: aadA2, dfr12 y orfF identificados en la región variable de los 26 aislados son los genes casetes más frecuentemente identificados y reportados en el interior de integrones clase 1 (Shahcheraghi et al 2014). Se han identificado más de 130 diferentes genes casete que contienen diversos genes de resistencia a diferentes familias de antibióticos como betalactámicos, aminoglucósidos, cloranfenicol, macrólidos, sulfonamidas, trimetroprim, eritromicina y rifampicina (Hou et al 2015).…”
Section: Discussionunclassified