In vitro susceptibility to methicillin, vancomycin and linezolid of staphylococci isolated from bloodstream infections in eastern Turkey

Abstract

Staphylococcus species are one of the major causes of bacterial bloodstream infections. Multi-resistant staphylococci infections are major therapeutic problems. This study was aimed to detect methicillin, linezolid and vancomycin susceptibilities of Staphylococcus isolates. A total of 870 Staphylococcus strains isolated from blood cultures of hospitalized patients with BSI. Antimicrobial susceptibilities of methicillin, linezolid and vancomycin were detected according to the Clinical and Laboratory Standards Institute (CLSI). A total of 771 (88.6%) isolates were coagulase-negative staphylococci (CoNS). 700 (80.5%) isolates were methicillin-resistant (MR) and 170 (19.5%) were methicillin-susceptible (MS). All the MS isolates were also susceptible to linezolid. However 15 (1.7%) of MR strains were resistant to linezolid. The minimum inhibitory concentration range for the linezolid-resistant isolates by Etest was 6–32 μg/mL. The difference between linezolid susceptibilities for MS and MR staphylococci was not quite statistically significant (p = 0.052). There was no statistically significant difference between S. aureus and CoNS isolates for linezolid susceptibility. All of the isolates were susceptible to vancomycin. In conclusion, linezolid is currently an efficient option for the treatment of methicillin-resistant staphylococci infections.

Study of biofilm formation, structure and antibiotic resistance in Staphylococcus saprophyticus strains causing urinary tract infection in women in Ahvaz, Iran

“…Similar to our results, 17.6% of the S. saprophyticus isolates were resistant to sulfamethoxazole/trimethoprim [ 26 ]. In addition, the S. saprophyticus isolates described in this study were susceptible to vancomycin, linezolid and quinupristin/dalfopristin [ 27 ]. In S. saprophyticus isolates, the maximum resistance has been observed against clindamycin (46%), followed by ciprofloxacin and gentamicin (37%).…”

Determination of Meticillin Resistance and Investigation of Antibiotic Susceptibility of Staphylococcus aureus Strains Isolated from Clinical Samples

“…Ancak bu yoğun kullanım sonucunda vankomisine orta düzeyde duyarlı ve dirençli S.aureus suşlarının ortaya çıktığı bildirilmektedir (3,10) . Ülkemizde yapılan çeşitli çalışmalarda ve UAMDSS sürveyans verilerinde S.aureus suşlarında vankomisin direncine rastlanmamıştır (1,5,11,13,15,(17)(18)(19)(20)(23)(24)(25)(26)(27) . Biz de çalışmamızda bu verilerle uyumlu olarak vankomisin dirençli bir suş saptamadık.…”

Presence of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) in the oral cavity of pedodontics clinics patients

“…Günümüzde MRSA enfeksiyonlarının tedavisinde klinikte kullanımda olan vankomisin ve teikoplanin olmak üzere iki glikopeptid grubu antibiyotikler ve 2000'li yıllardan sonra kullanıma giren linezolid, daptomisin ve tigesiklin gibi antibiyotiklere karşı direnç dünyada ve ülkemizde nadir olarak bildirilmiştir. [23][24][25][26][27][28] Çalışmamızda bu antibiyotiklere karşı direnç gözlenmemiştir.…”