Efficacy of aqueous garlic extract on growth, aflatoxin B1 production, and Cyto-morphological aberrations of Aspergillus flavus, causing human ophthalmic infection: topical treatment of A. flavus keratitis

Ismaiel, Ahmed A.; Rabie, Gamal H.; Kenawey, Saied E.M.; El-Aal, M. Abd

doi:10.1590/s1517-83822012000400017

Cited by 12 publications

(4 citation statements)

References 3 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Investigations into the use of nanoparticle technology with terbinafine and silver have also shown promising results [189,214]. In addition, topical aqueous garlic extracts have been tested on rabbit keratitis models infected with A. flavus [76]. Nonetheless, fungal keratitis is a complex entity with many considerations when it comes to treatment.…”

Section: Treatmentmentioning

confidence: 99%

Pathogenesis of microbial keratitis

Lakhundi

Siddiqui

Khan

2017

Microbial Pathogenesis

155

113

View full text Add to dashboard Cite

Microbial keratitis is a sight-threatening ocular infection caused by bacteria, fungi, and protist pathogens. Epithelial defects and injuries are key predisposing factors making the eye susceptible to corneal pathogens. Among bacterial pathogens, the most common agents responsible for keratitis include Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumonia and Serratia species. Fungal agents of corneal infections include both filamentous as well as yeast, including Fusarium, Aspergillus, Phaeohyphomycetes, Curvularia, Paecilomyces, Scedosporium and Candida species, while in protists, Acanthamoeba spp. are responsible for causing ocular disease. Clinical features include redness, pain, tearing, blur vision and inflammation but symptoms vary depending on the causative agent. The underlying molecular mechanisms associated with microbial pathogenesis include virulence factors as well as the host factors that aid in the progression of keratitis, resulting in damage to the ocular tissue. The treatment therefore should focus not only on the elimination of the culprit but also on the neutralization of virulence factors to minimize the damage, in addition to repairing the damaged tissue. A complete understanding of the pathogenesis of microbial keratitis will lead to the rational development of therapeutic interventions. This is a timely review of our current understanding of the advances made in this field in a comprehensible manner. Coupled with the recently available genome sequence information and high throughput genomics technology, and the availability of innovative approaches, this will stimulate interest in this field.

show abstract

Section: Treatmentmentioning

confidence: 99%

Pathogenesis of microbial keratitis

Lakhundi

Siddiqui

Khan

2017

Microbial Pathogenesis

155

113

View full text Add to dashboard Cite

show abstract

“…Lactoferricin B and short imidazolium chains have shown anti-biofilm properties and have been studied as a possible component to add to contact lens cleaning solution or as an adjunct to help increase the susceptibility of fungi to anti-fungal agents [69,70]. Even topical aqueous garlic extract has been used in in vivo rabbit models infected with A. flavus [71].…”

Section: Methodsmentioning

confidence: 99%

Fungal Keratitis: Update for 2014

Stone

Tan

2014

Curr Ophthalmol Rep

View full text Add to dashboard Cite

Fungal keratitis is a challenging problem worldwide, and many obstacles remain to the effective prevention, diagnosis, and therapy of this vision-threatening condition. Recent research has highlighted progress in each of these facets of the clinical approach to keratomycosis. Increased awareness of contact lens-associated fungal keratitis has prompted regulators to pay greater attention to testing of contact lens solutions under realworld conditions. Related research has also delved into the mechanisms of fungal biofilm formation and related therapeutic targets. Advances in polymerase chain reaction methodologies promise to increase the rapidity and accuracy of diagnosis, thereby decreasing the delay in instituting appropriate therapy. Antifungal pharmacologic agents remain the first line of therapy, with the newer azole antifungal voriconazole being utilized in innovative ways, such as via intrastromal injection. Large prospective studies such as the Mycotic Ulcer Treatment Trial have helped delineate optimal treatment algorithms, and variations in surgical techniques and postoperative regimens continue to be refined. Natamycin may still be more effective than other recently utilized antifungals for the treatment of Fusarium infections, but treatment failure is still a concern. Post-keratoplasty immunosuppression may benefit from the use of topical calcineurin inhibitors such as cyclosporine and tacrolimus, given their intrinsic antifungal properties. It can be argued that the prevention, diagnosis, and treatment of fungal keratitis lag behind the state of the art for bacterial keratitis, but dramatic improvements are undoubtedly on the horizon.

show abstract

“…S. pneumoniae, S. aureus, S. pyogenes, H. influenzae and anaerobic bacteria such as Fusobacterium & Peptostreptococcal species are the pathogens most frequently associated with orbital cellulitis. Some cases of orbital cellulitis have been linked to bacteria such Aeromonashydrophila, Pseudomonas aeruginosa, and Eikenellacorrodens [43].…”

Section: Preseptal and Orbital Cellulitismentioning

confidence: 99%

Recent approaches to combat various infections in eye

Sharma¹,

Rani

2022

ijhs

View full text Add to dashboard Cite

The prevalence of various eye related disorder is increasing rapidly among the global population and the microorganism borne ocular infections are emerging as biggest threat to the healthy functioning of eye during the past few years. Conjunctivitis, keratitis, endophthalmitis, blepharitis, uveitis, cellulitis, and ocular herpes are a few of the more common ocular illnesses. The arrival of novel technologies including nanotechnology and ocular implant are giving a hope to the healthcare sector via improved therapeutic potential and safety profile in the field of ocular infections treatment. This article enlisted major ocular infections, along with the physiology, prevention and treatment methods. The review article also highlighted information related to the available treatments for various ocular infections and recent patent insight of emerging technologies.

show abstract

Efficacy of aqueous garlic extract on growth, aflatoxin B1 production, and Cyto-morphological aberrations of Aspergillus flavus, causing human ophthalmic infection: topical treatment of A. flavus keratitis

Cited by 12 publications

References 3 publications

Pathogenesis of microbial keratitis

Pathogenesis of microbial keratitis

Fungal Keratitis: Update for 2014

Recent approaches to combat various infections in eye

Contact Info

Product

Resources

About