2011
DOI: 10.1590/s1517-83822011000400012
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Abstract: Antimicrobial therapy may cause changes in the resident oral microbiota, with the increase of opportunistic pathogens. The aim of this study was to compare the prevalence of Candida, Staphylococcus, Pseudomonas and Enterobacteriaceae in the oral cavity of fifty patients undergoing antibiotic therapy for pulmonary tuberculosis and systemically healthy controls. Oral rinsing and subgingival samples were obtained, plated in Sabouraud dextrose agar with chloramphenicol, mannitol agar and MacConkey agar, and incuba… Show more

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Cited by 10 publications
(7 citation statements)
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“…Its predominance in the oral cavity has been demonstrated (6,12,13). Several non-albicans species were also isolated, a phenomenon identified in long-term antibiotic users, immunossupressed and chronic pathologies patients (14)(15)(16). For example, Alberth et al (15) observed the substitution of C. albicans for non-albicans species (C. kefyr, C. lusitaniae, C. sake, C. tropicalis) in children with cancer, especially in the stages of severe neutropenia.…”
Section: Discussionmentioning
confidence: 99%
“…Its predominance in the oral cavity has been demonstrated (6,12,13). Several non-albicans species were also isolated, a phenomenon identified in long-term antibiotic users, immunossupressed and chronic pathologies patients (14)(15)(16). For example, Alberth et al (15) observed the substitution of C. albicans for non-albicans species (C. kefyr, C. lusitaniae, C. sake, C. tropicalis) in children with cancer, especially in the stages of severe neutropenia.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, the presence of TB and being on TB treatment have also been reported as risk factors for developing OC. Querido et al . found that TB medication alone could result in higher colonization rates of OC.…”
Section: Discussionmentioning
confidence: 99%
“…Despite maintenance of overall gut microbiota diversity, studies in both, mice and men, revealed standard anti-TB therapy induced long lasting microbiota alterations including reduction of Clostridiales, Bifidobacterium and Lactobacillus amongst others [179,180]. Thus, dysbiosis, either caused by M. tuberculosis infection or antibiotic treatment, could potentially affect immune functions, enhance susceptibility to secondary infections [181][182][183][184][185][186][187] and subsequent exacerbated pathology [188,189].…”
Section: Microbiome Guided Treatment Perspectivesmentioning
confidence: 99%