Antifungal activity of Piper diospyrifolium Kunth (Piperaceae) essential oil

Vieira, Silvia Cristina Heredia; Paulo, Luis Fernando de; Svidzinski, Terezinha Inez Estivaleti; Filho, Benedito Prado Dias; Nakamura, Celso Vataru; Souza, Amanda de; Young, Maria Cláudia Marx; Cortez, Diógenes Aparı́cio Garcia

doi:10.1590/s1517-83822011000300020

Cited by 15 publications

(8 citation statements)

References 3 publications

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“…The predominance of sesquiterpenes in leaves has been reported by other authors for the genus Piper (Mesquita et al, 2005;Vieira et al, 2011). While the predominance of phenylpropanoids in roots was the first report in the literature for the species P. aduncum L. The identification of sesquiterpenes in the leaves and phenylpropanoids in roots may be associated with their role.…”

Section: Resultssupporting

confidence: 57%

Essential oil of monkey-pepper (Piper aduncum L.) cultivated under different light environments

Pacheco

Avelar

Alvarenga

et al. 2016

Industrial Crops and Products

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The monkey-pepper (Piper aduncum L.) is an herbaceous species and essential oil producer, with biological activities such as insecticidal, antimicrobial, larvacidal and others. The cultivation of the plant is still incipient, being necessary to know the influence of some factors, among them, the light. Thus, the effects of different lighting conditions on the production and profile of the constituents of essential oils from leaves and roots of Piper aduncum L. were evaluated. Plants grown for 150 days in five light conditions: 100%, 70% and 50% of natural irradiance and nets of blue and red colors, also blocking 50% of natural light irradiance. The essential oils obtained by hydrodistillation from leaves and roots and analyzed by GC / MS. Roots showed higher amount of essential oil (0.11% w/w), which had no influence on light conditions. On leaves the biggest oil content was observed in 50% brightness (0.085% w/w). The essential oil of leaves was characterized by a high content of sesquiterpenes and roots of phenylpropanoids. The leaves are rich in E-nerolidol, linalol (14.28-16.65%); α-humulene (8.45-10.62%); cis-cadin-4-en-7-ol (7.48-12.24%) and caryophyllene (7.93-12.24%). While the root is rich in apiol (16.27-29.51%). Most major compounds increased in the environment rich in blue light. The variation in the production and essential oil constituents of P. aduncum L. depends on the light conditions and can is related to phenotypic and genetic factors. Therefore control of the light environment in growing conditions makes it necessary for obtaining raw material quality.

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Section: Resultssupporting

confidence: 57%

Essential oil of monkey-pepper (Piper aduncum L.) cultivated under different light environments

Pacheco

Avelar

Alvarenga

et al. 2016

Industrial Crops and Products

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“…P. arboretum and P. mosenii differed from the others as they had a greater composition of oxygenated sesquiterpene components. Various studies have demonstrated a preference of the Piper species to synthesize sesquiterpenes [28,29,30,31].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species

et al. 2016

Molecules

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Essential oils from fresh Piperaceae leaves were obtained by hydrodistillation and analyzed by gas chromatography mass spectrometry (GC-MS), and a total of 68 components were identified. Principal components analysis results showed a chemical variability between species, with sesquiterpene compounds predominating in the majority of species analyzed. The composition of the essential oil of Piper mosenii was described for the first time. The cytotoxicity of the essential oils was evaluated in peritoneal macrophages and the oils of P. rivinoides, P. arboretum, and P. aduncum exhibited the highest values, with cytotoxic concentration at 50% (CC 50 ) > 200 µg/mL. Both P. diospyrifolium and P. aduncum displayed activity against Leishmania amazonensis, and were more selective for the parasite than for the macrophages, with a selectivity index (SI) of 2.35 and >5.52, respectively. These SI values were greater than the 1 for the standard drug pentamidine. The antileishmanial activity of the essential oils of P. diospyrifolium and P. aduncum was described for the first time. P. rivinoides, P. cernuum, and P. diospyrifolium displayed moderate activity against the Mycobacterium tuberculosis H 37 Rv bacillus, with a minimum inhibitory concentration (MIC) of 125 µg/mL. These results are relevant and suggests their potential for therapeutic purposes. Nevertheless, further studies are required to explain the exact mechanism of action of these essential oils.

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“…The EOs showed significant activity against S. aureus (MIC 780 μg/mL, and for spring MIC, 1560 μg/mL), B. subtilis (MIC 780 μg/mL) and Streptococcus pyogenes (MIC 48–390 μg/mL) [ 37 ]. P. diospyrifolium EO from leaves, composed of cis -eudesma-6,11-diene (21.1%), β-caryophyllene (16.8%), and γ-muurolene (10.6%), was tested using agar diffusion assay and it showed significant potential against clinical fungal strains of C. albicans , C. parapsilosis , C. tropicalis in comparison to nystatin [ 55 ]. P. malacophyllum oil, composed mainly of camphor (32.8%), camphene (20.8%), and ( E )-nerolidol (9.1%), displayed a weak activity against S. aureus , P. aeruginosa , Acinetobacter baumanii (MIC 3700 µg/mL), B. cereus , and E. coli (MIC 1850 µg/mL) using the broth microdilution method [ 56 ].…”

Section: Biological Activitiesmentioning

confidence: 99%

“… Xambioá, Tocantins state, Brazil Aerial parts (HD) Germacrene D (15.2%), curzerene (28.7%), β-bisabolene (5.5%), ( Z )-α-bisabolene (23.2%) --- [ 131 ] P. dilatatum Rich. Carolina, Maranhão state, Brazil Aerial parts (HD) Limonene (19.4%), germacrene D (43.0%), bicyclogermacrene (13.2%) --- [ 131 ] P. diospyrifolium Kunth Universidade de São Paulo, Brazil Leaf (HD) ( E )-Nerolidol (18.2%), spathulenol (25.4%), caryophyllene oxide (7.7%), globulol (6.6%), humulene epoxide II (6.9%) --- [ 35 , 60 ] P. diospyrifolium Kunth Universidade de São Paulo, Brazil Floral (HD) a α-Copaene (47.7%), β-caryophyllene (12.3%), α-humulene (5.7%) --- [ 60 ] P. diospyrifolium Kunth Maringá, Parana state, Brazil Leaf (HD) Limonene (8.5%), ( E )-β-ocimene (5.8%), β-caryophyllene (16.8%), γ-muurolene (10.6%), cis -eudesma-6,11-diene (21.1%), germacrene B (6.2%) Antifungal, agar diffusion assay ( Candida albicans , Candida parapsilosis , Candida tropicalis ) [ 55 ] P. diospyrifolium Kunth Antonina, Paraná state, Brazil Leaf (HD) …”

Section: Table A1mentioning

confidence: 99%

Essential Oils from Neotropical Piper Species and Their Biological Activities

Silva

et al. 2017

IJMS

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The Piper genus is the most representative of the Piperaceae reaching around 2000 species distributed in the pantropical region. In the Neotropics, its species are represented by herbs, shrubs, and lianas, which are used in traditional medicine to prepare teas and infusions. Its essential oils (EOs) present high yield and are chemically constituted by complex mixtures or the predominance of main volatile constituents. The chemical composition of Piper EOs displays interspecific or intraspecific variations, according to the site of collection or seasonality. The main volatile compounds identified in Piper EOs are monoterpenes hydrocarbons, oxygenated monoterpenoids, sesquiterpene hydrocarbons, oxygenated sesquiterpenoids and large amounts of phenylpropanoids. In this review, we are reporting the biological potential of Piper EOs from the Neotropical region. There are many reports of Piper EOs as antimicrobial agents (fungi and bacteria), antiprotozoal (Leishmania spp., Plasmodium spp., and Trypanosoma spp.), acetylcholinesterase inhibitor, antinociceptive, anti-inflammatory and cytotoxic activity against different tumor cells lines (breast, leukemia, melanoma, gastric, among others). These studies can contribute to the rational and economic exploration of Piper species, once they have been identified as potent natural and alternative sources to treat human diseases.

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Antifungal activity of Piper diospyrifolium Kunth (Piperaceae) essential oil

Cited by 15 publications

References 3 publications

Essential oil of monkey-pepper (Piper aduncum L.) cultivated under different light environments

Essential oil of monkey-pepper (Piper aduncum L.) cultivated under different light environments

Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species

Essential Oils from Neotropical Piper Species and Their Biological Activities

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