Production of reactive oxygen (H2O2) and nitrogen (NO) intermediates and TNF-α in mice genetically selected for high (H) and low (L) antibody response and experimentally infected with Leptospira serovar pomona
Abstract:The aim of the present study was to evaluate the activity of macrophages, and the production of TNF-and antibodies against experimental infection by Leptospira serovar Pomona in mice genetically selected for High (H) or Low (L) humoral immune response. To evaluate macrophagic activity, peritoneal and splenic lavages were performed for determination of oxygen (H 2 O 2 ) and nitrogen (NO) intermediates. The production of the tumor necrosis factor (TNF-) was investigated through bioassays in serum and homogenates… Show more
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