Epidemiologically relevant antimicrobial resistance phenotypes in pathogens isolated from critically ill patients in a Brazilian Universitary Hospital

Carvalho, Rodolfo Henriques de; Filho, Paulo Pinto Gontijo

doi:10.1590/s1517-83822008000400005

Cited by 12 publications

(26 citation statements)

References 20 publications

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“…In Brazil, the incidence of MRSA is high, particularly in tertiary-care hospitals. In Uberlândia, rates vary from 49.5% among patients hospitalized in general medical clinics to 63.7% among patients in ICUs 6,7 .…”

Section: Methicillin-resistant Staphylococcus Aureus (Mrsa)mentioning

confidence: 99%

Active surveillance to determine the impact of methicillin resistance on mortality in patients with bacteremia and influences of the use of antibiotics on the development of MRSA infection

Porto

Santos

Filho

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Revista da Sociedade Brasileira de Medicina Tropical 46(6):713-718, Nov-Dec, 2013http://dx.doi.org/10. ABSTRACT Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is among the most important pathogens of nosocomial infections, mainly in intensive care units (ICUs), and accounts for 40-60% of all healthcare-associated S. aureus infections. We evaluated the incidence of nosocomial infection by S. aureus, identifi ed the risk factors for MRSA infection, and evaluated the effect of resistance to methicillin on mortality in patients. Methods: We conducted MRSA surveillance at a university hospital in Brazil from January 1, 2010, to December 31, 2010, and performed a retrospective case-control matched study to evaluate the frequency of subsequent MRSA bacteremia and death among patients. We evaluated and compared the risk factors between patients with MRSA and methicillin-sensitive Staphylococcus aureus (MSSA) infection. Results: Sepsis was the most common cause of infection (17.7/1,000 patient-days), followed by surgical site (11.4/1,000 patient-days), pneumonia (4.1/1,000 patient-days), and urinary tract infection (2.4/1,000 patient-days). The signifi cant risk factors were time of hospitalization, use of central vascular catheter (CVC), urinary catheter, nasogastric tube, parenteral nutrition, tracheostomy, mechanical ventilation, and previous antibiotic administration, the latter of which was the only independent risk factor for MRSA infection. Mortality was signifi cantly higher in patients with MRSA. The number of antibiotics tested was not related to increases in the frequency of MRSA/1,000 patient-days. The incidence of mortality attributable to MRSA (bloodstream infection) BSI was 50%. Conclusions: Surveillance results showed that the use of high levels of antibiotics was directly related to the development of MRSA infection, and the mortality attributable to MRSA in patients with bacteremia was signifi cant.

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Section: Methicillin-resistant Staphylococcus Aureus (Mrsa)mentioning

confidence: 99%

Active surveillance to determine the impact of methicillin resistance on mortality in patients with bacteremia and influences of the use of antibiotics on the development of MRSA infection

Porto

Santos

Filho

et al. 2013

Rev. Soc. Bras. Med. Trop.

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“…The first patient with a hospital infection by Imipenem resistant Pseudomonas aeruginosa was diagnosed in a woman with wound infection transferred from another hospital in the city and result in a major outbreak with 66 cases and 65% hospital mortality [7]. Low level of infection control practices, mainly low adherence to hand washing and isolation [19], result in a shift of an epidemic toward an endemic situation with spreading to the non-critical areas of the hospital [20].…”

Section: Discussionmentioning

confidence: 99%

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2017

SF J Material Res Let

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The aim of this study was to evaluate the risk factors and mortality of ventilator-associated pneumonia (VAPs) due to endemic multidrug-resistant P. aeruginosa (MR-PA) in a medical-surgical intensive care unit. A retrospective case-control study was carried out at a 15-bed medical-surgical in a Brazilian university-affiliated hospital. All patients who had VAPs caused by PA were included in the study. Univariate and mulvariate analyses were used to determine risk factors for PA-VAP. This organism was recovered from 38 patients and seventy eight controls (72) during the study. In multivariate analysis, previous colonization, tracheostomy and prior > three classes of antibiotics use were the only independent risk factors for PA-VAP. The hospital mortality rate of 62.10% (P<0.05) was higher in those patients with MR-PA VAP versus susceptible isolates (18.80%). Patients with tracheostomy previous colonization and >3 different classes of antibiotics ran a elevated risk of VAP and UTI-mortality was associated with MR PA.

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“…Additionally, the increased morbidity and mortality of patients and the rising costs of care reinforce the concern of hospital managers with the spread of these microorganisms (5) . Therefore, the use of long sleeved aprons during direct contact of professionals with infected or colonized patients by MR is mandatory and essential.…”

Section: Introductionmentioning

confidence: 99%

Costs of reusable and disposable aprons in a public teaching hospital

Pissinati

Haddad

Rossaneis

et al. 2014

Rev. esc. enferm. USP

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Objective To analyze the direct cost of reusable and disposable aprons in a public teaching hospital. Method Cross-sectional study of quantitative approach, focusing on the direct cost of reusable and disposable aprons at a teaching hospital in northern Paraná. The study population consisted of secondary data collected in reports of the cost of services, laundry, materials and supplies division of the institution for the year 2012 Results We identified a lower average cost of using disposable apron when compared to the reusable apron. The direct cost of reusable apron was R$ 3.06, and the steps of preparation and washing were mainly responsible for the high cost, and disposable apron cost was R$ 0.94. Conclusion The results presented are important for hospital managers properly allocate resources and manage costs in hospitals .

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Epidemiologically relevant antimicrobial resistance phenotypes in pathogens isolated from critically ill patients in a Brazilian Universitary Hospital

Cited by 12 publications

References 20 publications

Active surveillance to determine the impact of methicillin resistance on mortality in patients with bacteremia and influences of the use of antibiotics on the development of MRSA infection

Active surveillance to determine the impact of methicillin resistance on mortality in patients with bacteremia and influences of the use of antibiotics on the development of MRSA infection

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Costs of reusable and disposable aprons in a public teaching hospital

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