Inhibitory effect of Cinnamomum zeylanicum Blume (Lauraceae) essential oil and beta-pinene on the growth of dematiaceous moulds

Abstract

Dematiaceous moulds are pathogen microorganisms able to act as etiological agents of mycoses with different degrees of severity. This study evaluated the effectiveness of Cinnamomum zeylanicum Blume essential oil and β-pinene in inhibiting the growth of various strains of dematiaceous moulds (Alternaria brassicola, Cladosporium herbarium, C. resinae, C. cladosporioides, Chaetomum globosum, Curvularia sp., Fonsecaea compacta, Piedraia hortae). Antimicrobial assays were led by determining the Minimum Inhibitory Concentration-MIC using the solid medium diffusion procedure and observing the interference of the MIC values on the mould radial mycelial growth along 14 days. MIC values found to C. zeylanicum essential oil oscillated between 63 and 125 µL/mL. β-pinene showed MIC value of 125 µL/mL for the most mould strains, however C. resinae and C. globosum were resistant to it in all assayed concentrations. MIC values found to C. zeylanicum essential oil and β-pinene presented intense fungicidal effect noted by a total inhibition of the mycelial growth of C. cladosporioides and F. compacta along 14 days of exposure. These results showed the intense antimould potential of C. zeylanicum essential oil and β-pinene which could be regarded in a rational use in pharmaceutical formulations used to treat some mycoses, particularly, those caused by dematiaceous moulds.

Susceptibilities of Candida albicans Mouth Isolates to Antifungal Agents, Essentials Oils and Mouth Rinses

“…In this study, cinnamon was the most efficient oil. Previous studies recognize that cinnamon oil is an efficient antifungal or anti-candidal agent [36,37,[40][41][42] and have interest as a source of natural products for potential use as alternative drugs to heal many infectious diseases [43][44][45]. Besides cinnamon, other essential oils exhibited high efficacy, as laurel and mint.…”

Anti-Candida activity and chemical composition of Cinnamomum zeylanicum blume essential oil

“…Several biological properties of C. zeylanicum have been described such as antiseptic, analgesic, anti-spasmodic, astringent, insecticide and parasiticide properties (Moreira et al 2007). Studies have shown that the essential oil obtained from its leaves has broad antimicrobial activity (Moreira et al 2007;Khan et al 2008). Therefore, the purpose of this study was to evaluate the anti-Candida activity and to identify the chemical composition of essential oil extracted from C. zeylanicum leaves.…”

“…This species belongs to Lauraceae family, is native to Indonesia and cultivated in various regions of the world. Several biological properties of C. zeylanicum have been described such as antiseptic, analgesic, anti-spasmodic, astringent, insecticide and parasiticide properties (Moreira et al 2007). Studies have shown that the essential oil obtained from its leaves has broad antimicrobial activity (Moreira et al 2007;Khan et al 2008).…”

Comparison of the Contents and Antimicrobial Activities of Commercial and Natural Cinnamon Oils

“…Moreira et al found that essential oil of C. zeylanicum has a synergistic activity with b-pinene and suggested that these compounds may be an alternative to be inserted in pharmaceutical products as antimold agents [22] . Ooi et al found that both oil and pure cinnamaldehyde of C. cassia were equally effective in inhibiting the growth of bacteria including Gram positive and Gram negative and fungi.…”