Antibiotic susceptibility of Moraxella bovis recovered from outbreaks of Infectious Bovine Keratoconjunctivitis in Argentina, Brazil and Uruguay between 1974 and 2001

Conceição, Fabrício Rochedo; Bertoncelli, Diane Maria; Storch, Otávio Brod; Paolicchi, Fernando Alberto; Cobo, Ana Lia; Gil-Turnes, Carlos

doi:10.1590/s1517-83822004000300018

Cited by 9 publications

(7 citation statements)

References 6 publications

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“…Results obtained in this study showed that most of the strains were susceptible to the antibiotics used in the treatment of IBK [20]. Another interesting finding was that the antibiotic resistance profile differed between M. bovis and M. bovoculi.…”

Section: Discussionmentioning

confidence: 57%

Diversity of Moraxella spp. strains recovered from infectious bovine keratoconjunctivitis cases in Uruguay

Sosa

Zunino

2013

J Infect Dev Ctries

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Background: Infectious bovine keratoconjunctivitis (IBK) is the most common ocular disease that affects cattle throughout the world and it has a very significant economic impact. IBK is caused by members of the genus Moraxella and therapeutic and preventive measures have shown limited success. Vaccines, most of them chemically inactivated bacterins, generally induce a limited protection. Methodology: In this study, the genetic diversity of Uruguayan clinical Moraxella bovis and Moraxella bovoculi isolates was assessed by RAPD-PCR, ERIC-PCR and BOX-PCR fingerprinting. Also, antibiotic resistance of the Moraxella spp. isolates was assessed utilizing the disk diffusion method. Results: When interspecific molecular diversity was assessed, different bands patterns were observed even within a single outbreak of IBK, showing the coexistence of different genotypes of Moraxella spp. The high genetic diversity within M. bovis and M. bovoculi isolates did not permit to correlate isolates DNA fingerprints with geographical origins, dates or even with both different Moraxella species. Antibiotics resistance patterns showed significant differences between M. bovis and M. bovoculi. Conclusions: This is the first study of diversity that includes M. bovis and M. bovoculi associated to IBK cases. Genetic diversity did not allow to correlate DNA fingerprints of the isolates with geographical origins, isolation dates or even both different Moraxella species. Antibiotics resistance patterns showed differences between M. bovis and M. bovoculi. This remarkable variation within isolates could explain the partial protection induced by commercial vaccines. All these findings could be important for the design of prevention or treatment strategies against IBK.

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Section: Discussionmentioning

confidence: 57%

Diversity of Moraxella spp. strains recovered from infectious bovine keratoconjunctivitis cases in Uruguay

Sosa

Zunino

2013

J Infect Dev Ctries

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“…21,23,46 Similarly, Conceicao et al distributed 28 isolates obtained within Argentina, Brazil, and Uruguay into seven serogroups using a different serogrouping system based on the cross-reactivity indices of regional isolates. 47 Experimental challenges demonstrate that immunisation with sufficient quantities of purified M bovis pili can confer protection against colonisation and disease, 39,44,45,48 and cloned pili produced by recombinant DNA technology provide an equally effective level of protection. 46 However, results from a field trial with a commercial piliated, formalin-inactivated, aluminium hydroxide-adjuvanted, whole-cell M bovis bacterin do not show a significant affect on the incidence of IBK but demonstrate a reduction in lesion severity and the number of treatments required.…”

Section: Subunit Vaccinesmentioning

confidence: 99%

Infectious bovine keratoconjunctivitis vaccine development

Mcconnel

House

2005

Aust Veterinary J

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Infectious bovine keratoconjunctivitis is a common and highly contagious ocular disease affecting cattle worldwide. The tremendous economic losses attributable to this disease warrant continued investigation into methods of prevention. Multiple virulence factors have been linked to the primary aetiologic agent, Moraxella bovis. Efforts to develop an efficacious vaccine have primarily focused upon the use of surface pili or cytolysin to stimulate host immunity; however, M. bovis possesses other virulence determinants that include proteases, fibrinolysins, phospholipases and other cell surface components such as outer membrane proteins. These potentially conserved antigens provide additional possibilities for vaccine development. Examination of appropriate antigen presentation is necessary to attain an adequate immune response. Further, the potential for antigenic diversity as well as epitope conversion requires continuous epidemiological surveillance of isolates recovered from outbreaks. Current work targeting conserved immunogens provides hope for efficacious vaccines that when used in tandem with proper management may control, if not prevent, infectious bovine keratoconjunctivitis.

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“…The genus Moraxella actually comprises both coccoid and rod-shaped bacteria, and the classification of M. catarrhalis has been rather complex, the bacterium being alternatively named Neisseria catarrhalis, Branhamella catarrhalis, Moraxella (Branhamella) catarrhalis, and now the preferred M. catarrhalis. Though other Moraxella species are associated with infection in animals, M. catarrhalis is an exclusively human pathogen [2,3]. Moreover, in contrast to M. catarrhalis, other exclusively humanadapted Moraxella species are infrequently associated with disease [4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Moraxella catarrhalis: A mini review

Hays

2015

J Pediatr Infect Dis

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Moraxella catarrhalis is a human-specific bacterium previously discounted as a simple commensal organism with only limited pathogenic potential. This view has changed considerably and we now know that M. catarrhalis is associated with a range of disease states affecting both children and adults. In particular, M. catarrhalis tends to be associated with upper respiratory tract infections, including otitis media and sinusitis in children and lower respiratory tract infections in adults with pre-existing pulmonary disease, e.g., exacerbations of chronic obstructive pulmonary disease. Colonization with this bacterium is especially common in infants and young children, the age group most affected by M. catarrhalis-mediated disease. Research is just beginning to unravel the complex interaction between this pathogen and the human host and is providing insights into its diverse genetic population structure and numerous virulence traits. These latter markers include multiple potential cellular adhesion molecules that are currently being researched as potential vaccine candidates. This mini-review is intended to provide the reader with a short introduction to M. catarrhalis as a pathogen and includes recent advances in the understanding of mechanisms associated with bacterial virulence.

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Antibiotic susceptibility of Moraxella bovis recovered from outbreaks of Infectious Bovine Keratoconjunctivitis in Argentina, Brazil and Uruguay between 1974 and 2001

Cited by 9 publications

References 6 publications

Diversity of Moraxella spp. strains recovered from infectious bovine keratoconjunctivitis cases in Uruguay

Diversity of Moraxella spp. strains recovered from infectious bovine keratoconjunctivitis cases in Uruguay

Infectious bovine keratoconjunctivitis vaccine development

Moraxella catarrhalis: A mini review

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