2002
DOI: 10.1590/s1517-83822002000300001
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Abstract: The colicins are protein compounds produced by, and active against, Escherichia coli and others members of Enterobacteriaceae family. At least 34 different colicins have been described and found to share an interesting number of features. In the present review we focus on the major characteristics of colicins of gramnegative bacteria and explore their production and practical applications.

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Cited by 25 publications
(32 citation statements)
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“…Colicin production is a strategy commonly employed for many bacteria to take advantages in the competition with others (Cursino et al . ). The fact that O113:H21 is largely present in the animal reservoir and the environment (Feng et al .…”
Section: Discussionmentioning
confidence: 97%
“…Colicin production is a strategy commonly employed for many bacteria to take advantages in the competition with others (Cursino et al . ). The fact that O113:H21 is largely present in the animal reservoir and the environment (Feng et al .…”
Section: Discussionmentioning
confidence: 97%
“…Under normal conditions transcription of these bacteriocin operons is strongly repressed by the LexA protein, (the repressor of the SOS genes) except for cloacin DF13. These bacteriocin operons generally contain two LexA boxes in tandem, overlapped by one or two bases [4] and they are located just downstream of the Pribnow box [11]. Binding of LexA dimer to each box results in DNA bending, adding to the blockage of transcription as shown in Figure 2 (a) [12].…”
Section: Regulationmentioning
confidence: 99%
“…For therapeutic applications, E. coli strains producing bacteriocins are available under the names of MUTAFLOR and SYMBIOFLOR proved successful in the treatment of odiopathic chronic constipation as well as functional intestinal disorder and chronic inflammatory bowel disease [4]. Studies have shown that protein bacteriocin like colicins specifically inhibit the proliferation of cancer cells however, bacteriocin specificity for tumor cells is dependent on the cell line used [62].…”
Section: Therapeutic Applicationmentioning
confidence: 99%
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“…Colicin is one such antimicrobial biomolecule produced by certain members of the family Enterobacteriaceae, which provides a competitive edge against microorganisms that are not immune or resistant (3)(4)(5)(6). Colicin producers express the immunity protein constitutively, which forms a complex with the colicin protein, thereby preventing "cell suicide."…”
mentioning
confidence: 99%