2000
DOI: 10.1590/s1517-83822000000200016
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Abstract: The lethal action in Balb/c mice of 80 oral Fusobacterium nucleatum recovered from patients with adult periodontitis, healthy subjects or Cebus apella monkeys was studied. Mice were inoculated intraperitoneally with each bacterial inoculum of 5 x 10 8 CFU/ml. All the clinical isolates induced weight and coordinated movements loss. Pathological alterations in liver, CNS, heart, and kidney with inflammatory reactions or vascular congestion were observed. Of all the tested F. nucleatum isolates, 61.2% from period… Show more

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Cited by 4 publications
(3 citation statements)
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“…Besides higher bacterial counts in periodontal diseased sites, we found more virulent bacterial strains. In addition, isolates from healthy subjects also showed pathogenic activity (17). …”
Section: Discussionmentioning
confidence: 99%
“…Besides higher bacterial counts in periodontal diseased sites, we found more virulent bacterial strains. In addition, isolates from healthy subjects also showed pathogenic activity (17). …”
Section: Discussionmentioning
confidence: 99%
“…Previously, others have determined that 0.1 OD 600 is equivalent to 2.4 × 10 8 CFU/mL of T. denticola [15] or P. gingivalis [18,19], 1 × 10 8 CFU/mL of F. nucleatum [20] and to 6 × 10 7 CFU/mL of L. lactis [21].…”
Section: Bacteria and Biofilm Growthmentioning
confidence: 99%
“…To ensure log-phase growth, bacteria were passaged at least once before use in experiments. Previous literature determined that a 0.1 absorbance at 600 nm of Treponema denticola [ 34 ], Porphyromonas gingivalis [ 37 , 38 ], or Fusobacterium nucleatum [ 39 ] suspension contains 2.4 × 10 8 CFU/mL, 2.4 × 10 8 CFU/mL, and 1 × 10 8 CFU/mL of each of the bacteria, respectively. Purity of the cultures was confirmed by 16S sequencing prior to their use in the experiments.…”
Section: Methodsmentioning
confidence: 99%