“…21,31,32 Red betel leaf infusion actually contains active substance, saponin, a type of glycoside found in many plants with characteristics as "surfactants". 4,7,12 Saponins (phytonutrients) has properties resembling soap, so often called as "natural detergent", that is a foaming solution classified by the structure of the complex aglykon into triterpenoid and steroid saponins. 4,26,33 This compound has a long hydrocarbon chain with ion tip which consists of clusters of non polar (hydrophobic) and polar (hydrophilic) groups.…”