2008
DOI: 10.1590/s1516-93322008000400004
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Abstract: INTRODUÇÃOAminoácidos são as unidades básicas da composição de uma proteína. Em humanos saudáveis, nove aminoácidos são considerados essenciais, uma vez que não podem ser sintetizados endogenamente e, portanto, devem ser ingeridos por meio da dieta. Dentre os aminoácidos essenciais, se incluem os três aminoácidos de cadeia ramificada (ACR), ou seja, leucina, valina e isoleucina, que apresentam, respectivamente, concentração plasmática média de 120, 220 e 63 µmol/L; concentração intramuscular na forma livre mé-… Show more

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Cited by 22 publications
(34 citation statements)
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“…Many studies have been conducted to clarify this effect, Protein synthesis regulation by leucine 31 as it was previously observed that leucine, besides serving as a direct substrate for protein synthesis, also contributes toward stimulating this process, exerting a positive effect on the phosphorylating proteins involved in the translation initiation process of mRNA (Rogero, Tirapegui, 2008).…”
Section: The Influence Of Leucine On the Pro-tein Synthesis Mechanismmentioning
confidence: 99%
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“…Many studies have been conducted to clarify this effect, Protein synthesis regulation by leucine 31 as it was previously observed that leucine, besides serving as a direct substrate for protein synthesis, also contributes toward stimulating this process, exerting a positive effect on the phosphorylating proteins involved in the translation initiation process of mRNA (Rogero, Tirapegui, 2008).…”
Section: The Influence Of Leucine On the Pro-tein Synthesis Mechanismmentioning
confidence: 99%
“…This effect is synergistic with insulin, which is an anabolic hormone with a critical role of maintaining muscle protein synthesis. However, insulin alone is not able to completely restore the rate of protein synthesis in muscle during the post-absorptive state, requiring protein or aminoacid consumption to fully restore the anabolic effect (Rogero, Tirapegui, 2008;Bolster, Kimbal, Jefferson, 2003).…”
Section: The Influence Of Leucine On the Pro-tein Synthesis Mechanismmentioning
confidence: 99%
See 2 more Smart Citations
“…Valine is a branchedchain amino acid that is mainly metabolized in the skeletal muscle, and it is responsible for body protein balance (Rogero & Tirapegui, 2008). Considering previous findings (Berres et al, 2011;Tavernari et al, 2013), it may be concluded that valine requirements for protein accretion are lower than those required for feed conversion in broilers.…”
Section: Resultsmentioning
confidence: 96%