Effect of crude extracts of leaves of Smallanthus sonchifolius (yacon) on glycemia in diabetic rats

The <i>in Vitro</i> Antioxidant Capacities of Hydroalcoholic Extracts from Roots and Leaves of <i>Smallanthus sonchifolius</i> (Yacon) Do Not Correlate with Their <i>in Vivo</i> Antioxidant Action in Diabetic Rats

“…The results of our measurements of AST and ALT activities in the plasma confirm previous observations that hydroalcoholic leaf extracts do not cause liver or kidney toxicity when administered at doses of 400 mg•Kg −1 during 14 days [12]. Similarly, no toxic effects were observed when a root extract was administered each day intragastrically at doses of 2000 mg•Kg −1 during a 4-month period [46].…”

“…Control (C) and diabetic (D) groups received saline in the same manner. The dose of the hydroalcoholic extracts of the leaves was 400 mg per Kg body weight as in a previous study [12]. The dose of the root extract was 1.06 mg per Kg, corresponding to 340 mg fructooligosaccharides per Kg, a value also based on previous investigations [9] [20] [29].…”

“…This is precisely the scope of the present work in which the action of yacon extracts on the oxidative state of the liver from diabetic rats was extensively investigated. Taking into account that the action of aqueous extracts of yacon leaves against diabetes is controversial [12], only hydroalcoholic extracts of yacon roots and leaves were used in the present work. Streptozotocin-induced diabetic rats were used as the experimental model, which should allow extrapolations to the liver of patients with type 1 diabetes.…”

In vitro cytotoxic potential of Yacon (Smallanthus sonchifolius) against HT-29, MCF-7 and HDFn cell lines

“…A review on the characteristics of yacon as a functional food (Delgado et al, 2013) states that yacon leaves contain several phenolic compounds that enhance growth of intestinal bacteria with good metabolic properties, inhibiting the attack of pathogens. Hydro-ethanolic crude extracts (400 mg/kg) of yacon leaves given orally to diabetic Wistar rats for 3, 7, 10 and 14 days were shown to significantly decrease fasting and post-prandial serum glucose (Baroni et al, 2008). This finding was further confirmed by another study that utilized methanol, butanol and chloroform extracts, given to Wistar rats at 50, 10 and 20 mg/kg body weight for eight weeks (Genta et al, 2010).…”

Research of Hypoglycemic Properties of Dry Extract of Vaccinium Myrtillus L.

“…Також, за даними фітохімічних досліджень, чорниця містить глікозиди міртилін та неомірти-лін (т. з. "рослинний інсулін") [3,4,8]. Встанов-лено також сприятливий вплив листя чорниці на процеси окисного фосфорилювання в мітохон-дріях печінки [6].…”