Estudo termoanalítico de comprimidos revestidos contendo captopril através de termogravimetria (TG) e calorimetria exploratória diferencial (DSC)

Bazzo, Giovana Carolina; Silva, Marcos Antônio Segatto

doi:10.1590/s1516-93322005000300004

Cited by 14 publications

(8 citation statements)

References 16 publications

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“…For the search for drug-excipient interactions in the binary mixtures 5 mg of drug were used with the same amount of excipient, in order to maximize the probability of observing an interaction. Then, multicomponent mixtures, as it occurs in dosage forms were evaluated [ 27 , 28 , 29 ].…”

Section: Methodsmentioning

confidence: 99%

Thermal Analysis Applied to Verapamil Hydrochloride Characterization in Pharmaceutical Formulations

et al. 2010

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Thermogravimetry (TG) and differential scanning calorimetry (DSC) are useful techniques that have been successfully applied in the pharmaceutical industry to reveal important information regarding the physicochemical properties of drug and excipient molecules such as polymorphism, stability, purity, formulation compatibility among others. Verapamil hydrochloride shows thermal stability up to 180 °C and melts at 146 °C, followed by total degradation. The drug is compatible with all the excipients evaluated. The drug showed degradation when subjected to oxidizing conditions, suggesting that the degradation product is 3,4-dimethoxybenzoic acid derived from alkyl side chain oxidation. Verapamil hydrochloride does not present the phenomenon of polymorphism under the conditions evaluated. Assessing the drug degradation kinetics, the drug had a shelf life (t90) of 56.7 years and a pharmaceutical formulation showed t90 of 6.8 years showing their high stability.

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Section: Methodsmentioning

confidence: 99%

Thermal Analysis Applied to Verapamil Hydrochloride Characterization in Pharmaceutical Formulations

et al. 2010

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“…Microcrystalline cellulose is widely used in pharmaceutical formulations as a binder/diluent; its compatibility has been studied in several solid formulations (Bazzo et al, 2005;Ceschel et al, 2003;Stulzer et al, 2008). Magnesium stearate is employed as a lubricant; it is incompatible with several drugs (Daniel et al, 2013;Tita et al, 2011;Handbook of Pharmaceutical Excipients, 2006) but is compatible with others (Verma et al, 2004;2005).…”

Section: Stability and Compatibility Assaymentioning

confidence: 99%

Compatibility and stability of valsartan in a solid pharmaceutical formulation

Julio

Zâmara

Garcia

et al. 2013

Braz. J. Pharm. Sci.

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Valsartan (VAL) is a highly selective blocker of the angiotensin II receptor that has been widely used in the treatment of hypertension. Active pharmaceutical ingredient compatibility with excipients (crospovidone, hypromellose, magnesium stearate, microcrystalline cellulose and titanium dioxide) is usually evaluated in solid pharmaceutical development. Compatibility and stability can be evaluated by liquid chromatography. Studies were performed using binary mixtures of 1:1 (w/w) VAL/excipient; samples were stored under accelerated stability test conditions (40 °C at 75% relative humidity). The results indicate that VAL is incompatible with crospovidone and hypromellose, which reduced the VAL content and gave rise to new peaks in the chromatogram due to degradation products. Valsartana (VAL) é um bloqueador altamente seletivo do receptor da angiotensina II, que tem sido amplamente utilizado para o tratamento da hipertensão. Testes de compatibilidade com excipientes usualmente empregados em formulações sólidas são utilizados no desenvolvimento de formulações sólidas. Neste trabalho, realizaram-se testes utilizando misturas binárias na proporção 1:1 (m/m) de VAL/excipiente e as amostras foram armazenadas em condições de estabilidade acelerada (40 °C em 75% de umidade relativa). Os resultados obtidos indicam a incompatibilidade de VAL com crospovidona e hipromelose, através da redução do teor de VAL e a presença de novos picos no cromatograma provenientes de produtos de degradação.Unitermos: Valsartana/compatibilidade. Valtasan/estabilidade. Hipertensão/tratamento. Calorimetria Exploratória Diferencial/análise de fármacos. Cromatografia líquida de alto desempenho/análise quantitativa.

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“…Among several papers published in this area, the most outstanding ones are: application of thermogravimetry (TG) in quality control of Milon (Cissampelos sympodialis Eichi.) Minispermaceae (Aragão et al, 2002), thermal analysis and compatibility study of zidovudine with excipients (Araujo et al, 2003); study of thermal stability of metronidazole tablets ; Thermal analysis study of captopril coated tablets by thermogravimetry (TG) and differential scanning calorimetry (DSC) (Bazzo & SILVA, 2005); thermoanalytical study of glibenclamide and excipients (Oliveira et al, 2004); thermoanalitycal study (TG, DTG and DSC) of in natura and processed coffee ; study, characterization and determination of the purity of commercial samples of saccharin ; determination of moisture content and ash content of commercial samples of guarana using conventional methods and thermal analysis (ARAÚJO et al, 2006); physicochemical characterization of fluid and spray dried extracts of Symphytum officinale L. , assessing the compatibility between fluoxetine and excipients used in the manufacture of capsules (Stulz & Tagliari, 2006); thermoanalytical study and drug-excipient compatibility of rifampicin and some medications used in the treatment of Tuberculosis (Alves, 2007), thermal stability and compatibility of hydroquinone (Tagliari et al, 2008).…”

Section: Thermal Analysismentioning

confidence: 99%