Microemulsões e fases líquidas cristalinas como sistemas de liberação de fármacos

Formariz, Thalita Pedroni; Urban, Maria Cristina Cocenza; Júnior, Arnóbio Antônio da Silva; Gremião, Maria Palmira Daflon; Oliveira, Anselmo Gomes de

doi:10.1590/s1516-93322005000300003

Cited by 59 publications

(52 citation statements)

References 51 publications

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“…As cabeças polares do tensoativo, na presença de aumento de fase aquosa estariam sendo hidratadas pela água devido à alta hidrofilia desses grupos, promovendo organizações mais rígidas e mais complexas, típicas de fase hexagonal. 36,37 Na Figura 7 também foi possível observar, sob luz polarizada, a presença de "cruzes de malta", sugerindo a presença de fase líquido-cristalina do tipo lamelar. Quando o sistema foi mantido em estufa a 37 ± 2 °C por 15 dias (Figura 6S) observou-se a presença de "estrias", o que sugere o aparecimento de fase líquido-cristalina hexagonal.…”

Section: Microscopia De Luz Polarizadaunclassified

Desenvolvimento de sistemas líquido-cristalinos empregando silicone fluido de co-polímero glicol e poliéter funcional siloxano

Chorilli¹,

Prestes²,

Rigon³

et al. 2009

Quím. Nova

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Recebido em 16/1/08; aceito em 22/9/08; publicado na web em 15/4/09 DEVELOPMENT OF LIQUID-CRYSTALLINE SYSTEMS USING SILICON GLYCOL COPOLYMER AND POLYETHER FUNCTIONAL SILOXANE. For the construction of the phase diagrams, the method of the aqueous titration was used. There were prepared 5 ternary diagrams, varying the surfactant and the oil phase. The liquid-crystalline phases were identified by polarized light microscopy. The formulations prepared with silicon glycol copolymer, polyether functional siloxane (PFS) and water (S 1 ) and with diisopropyl adipate, PFS and water (S 4 ) presented liquid-crystalline phases with lamellar arrangement. Moreover, after 15 days in hot oven (37 o C), the formulations presented hexagonal arrangement, evidencing the influence of the temperature in the organization of the system.

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Section: Microscopia De Luz Polarizadaunclassified

Desenvolvimento de sistemas líquido-cristalinos empregando silicone fluido de co-polímero glicol e poliéter funcional siloxano

Chorilli¹,

Prestes²,

Rigon³

et al. 2009

Quím. Nova

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“…This state is called mesophase: the prefix "meso-" means "intermediate". 178 LCs are divided into two categories: thermotropics, which are structured by means of temperature, and lyotropics, which occur by association with amphipathic compounds and solvents. The mesophase lyotropics are mostly lamellar, hexagonal, or cubic, 179 as shown in Figure 4.…”

Section: Liquid Crystalsmentioning

confidence: 99%

“…179,182,183 The LC systems significantly change the drug release profile and reduce the toxicity of drugs, improving clinical efficiency. 178 Hosmer et al in 2012, studied mesophase lamellar LCs formed with glycerides for the incorporation of the anticancer drug paclitaxel. 184 Paclitaxel is highly effective against various types of cancer, including oral cancer; [185][186][187] however, it has severe adverse effects associated with systemic drug administration, including hypersensitivity reactions, thrombocytopenia, and neutropenia.…”

Section: Liquid Crystalsmentioning

confidence: 99%

Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

Calixto¹,

Fonseca-Santos²,

Chorilli³

et al. 2014

IJN

143

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Oral cancer (oral cavity and oropharynx) is a common and aggressive cancer that invades local tissue, can cause metastasis, and has a high mortality rate. Conventional treatment strategies, such as surgery and chemoradiotherapy, have improved over the past few decades; however, they remain far from optimal. Currently, cancer research is focused on improving cancer diagnosis and treatment methods (oral cavity and oropharynx) nanotechnology, which involves the design, characterization, production, and application of nanoscale drug delivery systems. In medicine, nanotechnologies, such as polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, gold nanoparticles, hydrogels, cyclodextrin complexes, and liquid crystals, are promising tools for diagnostic probes and therapeutic devices. The objective of this study is to present a systematic review of nanotechnology-based drug delivery systems for oral cancers.

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Section: Introductionmentioning

confidence: 99%

“…They also offer some protection against photo-or thermal degradation and can promote increased water retention in the stratum corneum, providing increased skin hydration. Finally, LCSs promote the sustained release of active substances and physicochemical stability of emulsions (Formariz et al, 2005;Santos, Rocha Filho, 2007).Liquid crystals are not generally employed in formulations of microbiological preservatives because they have large amounts of surfactants that suppress the growth of micro-organisms. Moreover, the high concentration of oil limits water access, which is one of the main causes of antimicrobial action (Oliveira et al, 2007).…”

mentioning

confidence: 99%

Green tea glycolic extract-loaded liquid crystal systems: development, characterization and microbiological control

Bernegossi

Barbosa

Rustice

et al. 2016

Braz. J. Pharm. Sci.

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Liquid crystal systems (LCSs) have interesting cosmetic applications because of their ability to increase the therapeutic efficiency and solubility of active ingredients. The aim of the present research was to develop green tea glycolic extract-loaded LCSs, to characterize and to perform microbiological control. The ternary phase diagram was constructed using polysorbate 20, silicone glycol copolymer (SGC) , and distilled water with 1.5% glycolic green tea extract. The systems were characterized by polarized light microscopy. Formulations selected were characterized as transparent viscous systems and transparent liquid system indicated mesophases lamellar structure. The results of the microbiological analysis of mesophilic aerobic microorganisms (bacteria and fungi) revealed that the above formulation showed a biologic load <10 CFU/mL in all samples. In conclusion, liquid crystalline systems that have presented formation of a lamellar mesophases were developed. Furthermore, the formulation and products tested presented the adequate microbiological quality in accordance with official recommendations. Uniterms:Camellia sinensis/glycolic extract. Liquid crystal systems/cosmetic applications. Liquid crystal systems/characterization. Liquid crystal systems/microbiological control. INTRODUCTIONTechnological developments in the cosmetics industry and improved understanding of skin physiology have led to the incorporation of several active substances that are now commonly used in cosmetic formulations. Plant extracts, especially green tea glycolic extract, have been recently proposed for different purposes (Gianeti et al, 2013).Green tea, obtained from the plant Camellia sinensis, is rich in polyphenols, such as catechins. The most active catechin seems to be 3-gallate (-) epigallocatechin. Clinical studies show that green tea acts as a chemoprotectant and sunscreen agent with activities such as antioxidant, free radical scavenging, inhibiting the induction, initiation, promotion, and proliferation of carcinogenesis, antiinflammatory, antiangiogenic, inducer of apoptosis of carcinogen cells, metalloproteinase inhibitor, protector of the conversion of benign cells into malignant, and inhibitor of DNA damage (Pereira et al., 2009;Yun, Yang, 2015;Rodrigues et al., 2016).Studies performed by our research group compared pomegranate and green tea glycolic extracts (GTGE) in formulations and concluded that GTGE possessed greater bacterial growth inhibition measured as zone of inhibition than the other extracts, suggesting that GTGE has high antibacterial activity (Calixto et al., 2012).With the aim of obtaining final products with real benefits that can be perceived by consumers and to optimize the sensory attributes of these formulations, researchers have resorted to theories and scientific experimentations that were unique to the development of pharmaceutical preparations. Active substance delivery systems that were previously developed for pharmaceutical products (e.g., micro-and nanoemulsions and liquid-crystalline system...

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Microemulsões e fases líquidas cristalinas como sistemas de liberação de fármacos

Cited by 59 publications

References 51 publications

Desenvolvimento de sistemas líquido-cristalinos empregando silicone fluido de co-polímero glicol e poliéter funcional siloxano

Desenvolvimento de sistemas líquido-cristalinos empregando silicone fluido de co-polímero glicol e poliéter funcional siloxano

Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

Green tea glycolic extract-loaded liquid crystal systems: development, characterization and microbiological control

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