Pharmacodynamic and Pharmacokinetic Studies of β-Cyclodextrin:Dexamethasone Acetate Complexes in Mice

Rodrigues, Patrik Oening; A, Becker; Dellagnelo, Viviane Aparecida; Benetti, Cibele Nabhan; Pereira, Eduardo Manoel; Wagner, Theodoro Marcel; Silva, Marcos Antônio Segatto

doi:10.1590/s1516-8913201400874

Cited by 4 publications

(3 citation statements)

References 34 publications

(31 reference statements)

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“…Free celecoxib and celecoxib-β-cyclodextrin achieved significantly higher inhibition of the inflammation induced by carrageenan compared to control group but the inclusion complex was more effective than celecoxib alone in edema inhibition (Sensoy et al, 2009). In another study, dexamethasone-β cyclodextrin complexation did not decrease the edema inhibitory and anti-inflammatory action of dexamethasone (Rodrigues et al, 2014).…”

Section: Discussionmentioning

confidence: 90%

A novel gedunin-2-hydroxypropyl-β-cyclodextrin inclusion complex improves anti-nociceptive and anti-inflammatory activities of gedunin in rodents

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2022

NJPS

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Gedunin is a bioactive compound, obtained from Entandrophragma angolense (EA), which has limited therapeutic usefulness due to poor aqueous solubility and first-pass effects. Cyclodextrins are cyclic oligosaccharides that form complexes with poorly soluble compounds, thus enhancing their pharmacological activity. In this article, we evaluated the pharmacological activities of gedunin-2-hydroxypropyl-β-cyclodextrin complex (GCD) in rodents. The antinociceptive activity of GCD (50, 100, 200 mg/kg) and Gedunin (50mg/kg) was tested in acetic acid-induced writhing and formalin-induced paw licking in mice. The anti-inflammatory activity was investigated in carrageenan-induced paw oedema and air pouch inflammation models in rats. Leucocytes counts, Tumour Necrosis Factor-alpha (TNF-α) level, nitric oxide, malondialdehyde, reduced glutathione, and myeloperoxidase enzyme activities were assessed in the air pouch exudate. The GCD (200mg/kg) significantly decreased writhing response, reduced licking duration and decreased oedema compared with gedunin and control. Exudate volume and leucocyte count were significantly reduced by GCD (200 mg/kg), it decreased myeloperoxidase activity and inhibited TNF-α release. The carrageenan-induced GSH depletion, increased malondialdehyde and nitrite levels were significantly reversed by GCD (200 mg/kg) relative to gedunin and control. The GCD complex demonstrated significant antinociceptive and anti-inflammatory activities relative to gedunin alone via mechanisms associated with inhibition of oxidative stress and inflammation in rodents

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Section: Discussionmentioning

confidence: 90%

A novel gedunin-2-hydroxypropyl-β-cyclodextrin inclusion complex improves anti-nociceptive and anti-inflammatory activities of gedunin in rodents

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2022

NJPS

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“…printing processing and adding dexamethasone to the scaffold can be a good way to achieve a high dose in the target tissue and a low dose systemically, which can exert anti-inflammatory effects and reduce its side effects at the same time. However, since DEX is a lipophilic substance, its water solubility is low and it is not efficient when loaded into scaffolds [207,208]. Therefore, it is important to utilize a safe medium to load DEX more efficiently into scaffolds.…”

Section: Dexamethasonementioning

confidence: 99%

Review on Additives in Hydrogels for 3D Bioprinting of Regenerative Medicine: From Mechanism to Methodology

Fu¹,

Zhang²,

Fang³

et al. 2023

Preprint

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Regeneration of biological tissues in medicine is challenging, and 3D bioprinting offers an innovative way to create functional multicellular tissues. One common way in bioprinting is bioink which is one type of the cell-loaded hydrogel. For clinical application, however, the bioprinting still suffers from satisfactory performance, e.g. in vascularization, effective antibacterial, immunomodulation and regulation of collagen deposition. Many studies have incorporated different bioactive materials into the 3D printed scaffolds to optimize the bioprinting. Here, we review a variety of additives added to the 3D bioprinting hydrogel. The underlying mechanisms and methodology for biological regeneration are important and will provide useful basis for future research.

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“…Therefore, constructing a hybrid scaffold by using 3D printing processing and adding DEX to the scaffold can be a good way to achieve a high dose in the target tissue and a low dose systemically, which can exert anti-inflammatory effects and reduce its side effects at the same time. However, since DEX is a lipophilic substance, its water solubility is low and it is not efficient when loaded into scaffolds [ 230 , 231 ]. Therefore, it is important to utilize a safe medium to load DEX more efficiently into scaffolds.…”

Section: Immunomodulationmentioning

confidence: 99%

Review on Additives in Hydrogels for 3D Bioprinting of Regenerative Medicine: From Mechanism to Methodology

Fang,

Yang,

Liu

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

The regeneration of biological tissues in medicine is challenging, and 3D bioprinting offers an innovative way to create functional multicellular tissues. One common way in bioprinting is bioink, which is one type of the cell-loaded hydrogel. For clinical application, however, the bioprinting still suffers from satisfactory performance, e.g., in vascularization, effective antibacterial, immunomodulation, and regulation of collagen deposition. Many studies incorporated different bioactive materials into the 3D-printed scaffolds to optimize the bioprinting. Here, we reviewed a variety of additives added to the 3D bioprinting hydrogel. The underlying mechanisms and methodology for biological regeneration are important and will provide a useful basis for future research.

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Pharmacodynamic and Pharmacokinetic Studies of β-Cyclodextrin:Dexamethasone Acetate Complexes in Mice

Abstract: The aim of this study was to evaluate the in vivo activity of the anti-inflammatory and analgesic effects of a suspension of the complex composed of dexamethasone acetate (DMA) with β-cyclodextrin in comparison to

Cited by 4 publications

References 34 publications

A novel gedunin-2-hydroxypropyl-β-cyclodextrin inclusion complex improves anti-nociceptive and anti-inflammatory activities of gedunin in rodents

A novel gedunin-2-hydroxypropyl-β-cyclodextrin inclusion complex improves anti-nociceptive and anti-inflammatory activities of gedunin in rodents

Review on Additives in Hydrogels for 3D Bioprinting of Regenerative Medicine: From Mechanism to Methodology

Review on Additives in Hydrogels for 3D Bioprinting of Regenerative Medicine: From Mechanism to Methodology

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