Antitumor activity of C-phycocyanin from Arthronema africanum (Cyanophyceae)

Gardeva, Elena; Toshkova, Reneta; Yossifova, L.; Minkova, Kaledona; Ivanova, N. I.; Gigova, L.

doi:10.1590/s1516-89132014005000018

Cited by 41 publications

(11 citation statements)

References 36 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phycocyanin also scavenges free radicals from damaged nerve cells, which could avoid DNA oxidative damage cause from free radicals and prevent neuronal cell apoptosis 60 , 61 . There are more and more researches have shown that phycocyanin plays an effective anti-cancer role in various cancer cell types (such as breast cancer 57 , 62 , liver cancer 63 , lung cancer 64 , 65 , colon cancer 66 , Leukemia 67 and bone marrow cancer 68 and so on) in vitro and in vivo . Morcos first discovered the laser-induced cytotoxicity of phycocyanin, which could kill tumor cells, while the damage to normal tissue is minimal 69 .…”

Section: Phycocyanin: General Propertiesmentioning

confidence: 99%

“…Among them, phycocyanin, a marine drug, plays an anti-proliferation and pro-apoptotic effects on different cancer cell lines in vitro, while phycocyanin have no side effects on normal tissue cells 84 , 85 . More and more evidences have proved that phycocyanin has an effective anti-cancer effect on various cancer cell types (such as breast cancer 57 , 62 , liver cancer 63 , lung cancer 64 , 65 , colon cancer 66 , Leukemia 67 and bone marrow cancer 68 ) in vitro and in vivo . High-dose phycocyanin does not induce significant toxic symptoms or mortality in animal experiments 81 , 86 .…”

Section: Phycocyanin and Cancermentioning

confidence: 99%

See 1 more Smart Citation

Phycocyanin: A Potential Drug for Cancer Treatment

et al. 2017

View full text Add to dashboard Cite

Phycocyanin isolated from marine organisms has the characteristics of high efficiency and low toxicity, and it can be used as a functional food. It has been reported that phycocyanin has anti-oxidative function, anti-inflammatory activity, anti-cancer function, immune enhancement function, liver and kidney protection pharmacological effects. Thus, phycocyanin has an important development and utilization as a potential drug, and phycocyanin has become a new hot spot in the field of drug research. So far, there are more and more studies have shown that phycocyanin has the anti-cancer effect, which can block the proliferation of cancer cells and kill cancer cells. Phycocyanin exerts anti-cancer activity by blocking tumor cell cell cycle, inducing tumor cell apoptosis and autophagy, thereby phycocyanin can serve as a promising anti-cancer agent. This review discusses the therapeutic use of phycocyanin and focuses on the latest advances of phycocyanin as a promising anti-cancer drug.

show abstract

Section: Phycocyanin: General Propertiesmentioning

confidence: 99%

Section: Phycocyanin and Cancermentioning

confidence: 99%

Phycocyanin: A Potential Drug for Cancer Treatment

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Accumulating evidence shows that phycocyanin has a potent anticancer effect both in vitro and in vivo on a variety of cancer cell types, such as lung cancer 7 , colon cancer 8 , breast cancer 9 and bone marrow cancer 10 . In addition, administration of phycocyanin at the high doses from 0.25 to 5.0 g/kg body weight (w/w) does not induce noticeable symptoms of toxicity nor mortality in animals 11 .…”

mentioning

confidence: 99%

Phycocyanin Inhibits Tumorigenic Potential of Pancreatic Cancer Cells: Role of Apoptosis and Autophagy

Liao

Gao

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Pancreatic adenocarcinoma (PDA) is one of the most lethal human malignancies, and unresponsive to current chemotherapies. Here we investigate the therapeutic potential of phycocyanin as an anti-PDA agent in vivo and in vitro. Phycocyanin, a natural product purified from Spirulina, effectively inhibits the pancreatic cancer cell proliferation in vitro and xenograft tumor growth in vivo. Phycocyanin induces G2/M cell cycle arrest, apoptotic and autophagic cell death in PANC-1 cells. Inhibition of autophagy by targeting Beclin 1 using siRNA significantly suppresses cell growth inhibition and death induced by phycocyanin, whereas inhibition of both autophagy and apoptosis rescues phycocyanin-mediated cell death. Mechanistically, cell death induced by phycocyanin is the result of cross-talk among the MAPK, Akt/mTOR/p70S6K and NF-κB pathways. Phycocyanin is able to induce apoptosis of PANC-1 cell by activating p38 and JNK signaling pathways while inhibiting Erk pathway. On the other hand, phycocyanin promotes autophagic cell death by inhibiting PI3/Akt/mTOR signaling pathways. Furthermore, phycocyanin promotes the activation and nuclear translocation of NF-κB, which plays an important role in balancing phycocyanin-mediated apoptosis and autosis. In conclusion, our studies demonstrate that phycocyanin exerts anti-pancreatic cancer activity by inducing apoptotic and autophagic cell death, thereby identifying phycocyanin as a promising anti-pancreatic cancer agent.

show abstract

“…Previous assessment of the anti-tumour activity of C-PC have been focused on the C-PC isolated mainly from Spirulina platensis [5], in addition to other rich sources including Arthronema africanum [43], Limnothrix sp. [44,45], Porphyra yezoensis [46], and Porphyra haitanensis [47].…”

Section: Discussionmentioning

confidence: 99%

A highly purified C-phycocyanin from thermophilic cyanobacterium Thermosynechococcus elongatus and its cytotoxic activity assessment using an in vitro cell-based approach

El-Mohsnawy

Abu-Khudir

2020

Journal of Taibah University for Science

View full text Add to dashboard Cite

C-phycocyanin (C-PC) is a protein-pigment widely used in nutrition and pharmaceutical applications. High purity of C-PC is a limiting factor required for its medical use; hence purity improvement with successful plausible pharmaceutical application is the state of the art of the present work. Highly purified C-PC (A 620 /A 280 = 6.6) was obtained from Thermosynechococcus elongatus. Combined enzymatic cell wall degradation, cellular exposure to high pressure, sonication, and one-time homogenization was found to be an effective purification protocol. Purified complex was confirmed by SDS-PAGE and UV-absorption spectral analysis. Cytotoxic effect of the obtained C-PC was assessed in vitro using a panel of cancer cells. Results showed that MCF-7 cells were most sensitive to C-PC (IC 50 = 158.9 µM) compared to Caco-2 (IC 50 = 258.3 µM) and HepG2 (IC 50 = 277.5 µM) cells. Our findings shed the light on the potential medical use of C-PC isolated from T. elongatus in controlling cancer cells.

show abstract

Antitumor activity of C-phycocyanin from Arthronema africanum (Cyanophyceae)

Abstract: Pure C-phycocyanin (C-PC) was isolated from Arthronema africanum to evaluate its potential antitumor effects in vivo and in vitro. Experimental myeloid Graffi tumor in hamsters was used as a model. The cell proliferation assayshowed that C-PC treatment, at concentration of 100 µg mL

Cited by 41 publications

References 36 publications

Phycocyanin: A Potential Drug for Cancer Treatment

Phycocyanin: A Potential Drug for Cancer Treatment

Phycocyanin Inhibits Tumorigenic Potential of Pancreatic Cancer Cells: Role of Apoptosis and Autophagy

A highly purified C-phycocyanin from thermophilic cyanobacterium Thermosynechococcus elongatus and its cytotoxic activity assessment using an in vitro cell-based approach

Contact Info

Product

Resources

About