Design and evaluation of famotidine mucoadhesive nanoparticles for aspirin induced ulcer treatment

Patel, Daywin; Patel, Jayvadan K.

doi:10.1590/s1516-89132013000200007

Cited by 17 publications

(9 citation statements)

References 18 publications

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“…Drugs of this class show poor aqueous solubility and low permeability [15]. Due to which its oral formulations have not been successful due to low water solubility issues (1.1 mg⋅ml −1 ) and unfavorable pharmacokinetic parameters, including low oral bioavailability (43%) and a short plasma half-life (2.59 hrs) [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Fabrication, Characterization, and In Vivo Evaluation of Famotidine Loaded Solid Lipid Nanoparticles for Boosting Oral Bioavailability

Shafique

Khan

et al. 2017

Journal of Nanomaterials

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Famotidine as H 2 receptor has antagonistic effects on gastric secretion. Unfortunately, its hydrophobic nature contributes to its variable and poor oral bioavailability. In the current study efforts are being made to fabricate famotidine loaded solid lipid nanoparticles with narrow size distribution. Prepared nanoformulations were pharmaceutically evaluated to confirm the desired boosted oral bioavailability. Famotidine loaded nanoformulation (FFSe-4) showed particle size 111.9±1.3 nm, polydispersity index 0.464 ± 0.03, zeta potential −33.46 ± 2 mV, entrapment efficiency 84 ± 2.7%, and drug loading capacity 2.709 ± 0.13%. Drugexcipients compatibility was confirmed by Fourier transformed infrared spectroscopy. Scanning electron microscopy confirmed spherical shaped, nanosized particles. Differential scanning calorimetry and powder X-ray diffractometry confirmed the change in crystalline nature. Prepared nanoformulation was more stable at refrigerated temperature. In vitro study showed that drug release time is proportional to drug pay load and followed zero order kinetics. Release exponent ( > 0.5) confirmed non-Fickian-diffusion mechanism for drug release. In vivo pharmacokinetic studies showed 2.06-fold increase in oral bioavailability of famotidine dispersed in solid lipid nanoparticles compared to commercial product. These results authenticate solid lipid nanoparticles as drug delivery system and propose prolonged release with improved oral bioavailability for famotidine.

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Section: Introductionmentioning

confidence: 99%

Fabrication, Characterization, and In Vivo Evaluation of Famotidine Loaded Solid Lipid Nanoparticles for Boosting Oral Bioavailability

Shafique

Khan

et al. 2017

Journal of Nanomaterials

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“…Nanotechnology has emerged to be one of the most powerful technology creating approaches in the past half a century. Nowadays, nanotechnology has spawned the development of a veritable plethora of novel nanoparticles for diverse applications, ranging from solar energy capture to cosmetics and drug delivery (Riehemann et al 2009;Patel and Patel 2013). With frequent exposure to dispersed nanoparticles from the composite products or workplaces, there is an increased chance for nanoparticles or nano composites to enter human body and to relocate in metabolism-active organs (Song et al 2009).…”

Section: Introductionmentioning

confidence: 99%

The Risk Evaluation of Tungsten Oxide Nanoparticles in Cultured Rat Liver Cells for Its Safe Applications in Nanotechnology

Türkez¹,

Sönmez²,

Turkez³

et al. 2014

Braz. arch. biol. technol.

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Tungsten (VI) oxide (WO 3 ) nanoparticles (NPs) are used for many industrial purposes in everyday life. However, their effects on human health have not been sufficiently evaluated. Therefore, the present study was designed to investigate the toxicity potentials of various concentrations (0 to 1000 ppm) of WO 3 NPs (<100 nm particle size) in cultured primary rat hepatocytes. The results of cell viability assay showed that the higher concentrations of dispersed WO 3 NPs (300, 500 and 1000 ppm) caused significant (p<0.05) decreases of cell viability. Also, dose dependent negative alterations were observed in oxidative status and antioxidant capacity levels after the application of WO 3 in cultured rat primary hepatocytes. The results of genotoxicity tests revealed that these NPs did not cause significant increases of micronucleated hepatocytes (MNHEPs) but increased 8-oxo-2-deoxyguanosine (8-OH-dG) levels as compared to the control culture.

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“…Nowadays, nanotechnology has spawned the development of a veritable plethora of novel nanoparticles for diverse applications, ranging from solar energy capture to cosmetics and drug delivery (Riehemann et al 2009;Patel and Patel 2013). With frequent exposure to dispersed nanoparticles from the composite products or workplaces, there is an increased chance for nanoparticles or nano composites to enter human body and to relocate in metabolism-active organs (Song et al 2009).…”

Section: Introductionmentioning

confidence: 99%

The Risk Evaluation of Tungsten Oxide Nanoparticles in Cultured Rat Liver Cells for Its Safe Applications in Nanotechnology

Türkez

Sönmez

Turkez

et al. 2014

Braz. arch. biol. technol.

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show abstract

Design and evaluation of famotidine mucoadhesive nanoparticles for aspirin induced ulcer treatment

Abstract: ABSTRACT

Cited by 17 publications

References 18 publications

Fabrication, Characterization, and In Vivo Evaluation of Famotidine Loaded Solid Lipid Nanoparticles for Boosting Oral Bioavailability

Fabrication, Characterization, and In Vivo Evaluation of Famotidine Loaded Solid Lipid Nanoparticles for Boosting Oral Bioavailability

The Risk Evaluation of Tungsten Oxide Nanoparticles in Cultured Rat Liver Cells for Its Safe Applications in Nanotechnology

The Risk Evaluation of Tungsten Oxide Nanoparticles in Cultured Rat Liver Cells for Its Safe Applications in Nanotechnology

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