Hepatoprotective efficacy of Hypnea muciformis ethanolic extract on CCl4 induced toxicity in rats

Bupesh, Giridharan; Amutha, C.; Vasanth, Sakthivel; Manoharan, Natesan; Raja, Ramalingam Senthil; Krishnamoorthy, Raju; Subramanian, P.

doi:10.1590/s1516-89132012000600008

Cited by 7 publications

(5 citation statements)

References 21 publications

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“…Finally, the hepatoprotective activity of red algae extracts has been also indicated to be associated with the prevention of oxidative stress. For instance, the oral administration of Hypnea musciformis ethanolic extract promoted hepatoprotective activity in liver damage-induced rodent models (Bupesh et al 2012). Moreover, similar effects were observed by the polyphenol-enriched extracts from Bryothamnion triquetrum, (Novoa et al 2019), the ethanol extract from Eucheuma cottonii (Wardani et al 2017), and the polysaccharide fraction from Porphyra yezoensis (Guo et al 2007).…”

Section: Other Activitiesmentioning

confidence: 84%

Biological properties and potential of compounds extracted from red seaweeds

et al. 2022

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Macroalgae have been recently used for different applications in the food, cosmetic and pharmaceutical industry since they do not compete for land and freshwater against other resources. Moreover, they have been highlighted as a potential source of bioactive compounds. Red algae (Rhodophyta) are the largest group of seaweeds, including around 6000 different species, thus it can be hypothesized that they are a potential source of bioactive compounds. Sulfated polysaccharides, mainly agar and carrageenans, are the most relevant and exploited compounds of red algae. Other potential molecules are essential fatty acids, phycobiliproteins, vitamins, minerals, and other secondary metabolites. All these compounds have been demonstrated to exert several biological activities, among which antioxidant, anti-inflammatory, antitumor, and antimicrobial properties can be highlighted. Nevertheless, these properties need to be further tested on in vivo experiments and go in-depth in the study of the mechanism of action of the specific molecules and the understanding of the structure–activity relation. At last, the extraction technologies are essential for the correct isolation of the molecules, in a cost-effective way, to facilitate the scale-up of the processes and their further application by the industry. This manuscript is aimed at describing the fundamental composition of red algae and their most studied biological properties to pave the way to the utilization of this underused resource.

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Section: Other Activitiesmentioning

confidence: 84%

Biological properties and potential of compounds extracted from red seaweeds

et al. 2022

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“…Therefore, effective removal of free radicals has been considered one strategy for treatment of liver injury. To achieve this, some natural products from various marine organisms are being investigated as important sources for the prevention of diseases associated with oxidative stress, even though various drugs have already been used in the treatment of hepatic disorders 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 . Recently, several compounds and extracts of the SCT have received a great deal of attention as novel therapeutic mixture candidates because of their antioxidant properties.…”

Section: Discussionmentioning

confidence: 99%

Ethanol extracts collected from the <i>Styela clava</i> tunic alleviate hepatic injury induced by carbon tetrachloride (CCl<sub>4</sub>) through inhibition of hepatic apoptosis, inflammation, and fibrosis

et al. 2017

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The Styela clava tunic (SCT) is known as a good raw material for preparing anti-inflammatory compounds, wound healing films, guided bone regeneration, and food additives. To investigate whether ethanol extracts of the SCT (EtSCT) could protect against hepatic injury induced by carbon tetrachloride (CCl4) in ICR mice, alterations in serum biochemical indicators, histopathology, hepatic apoptosis, inflammation, and fibrosis were observed in ICR mice pretreated with EtSCT for 5 days before CCl4 injection. EtSCT contained 15.6 mg/g of flavonoid and 37.5 mg/g phenolic contents with high 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (93.3%) and metal chelation activity (46.5%). The EtSCT+CCl4-treated groups showed decreased levels of ALT, LDH, and AST, indicating toxicity and a necrotic area in the liver, while the level of ALP remained constant. The formation of active caspase-3 and enhancement of Bax/Bcl-2 expression was effectively inhibited in the EtSCT+CCl4-treated groups. Furthermore, the levels of pro- and anti-inflammatory cytokines and the phosphorylation of p38 in the TNF-α downstream signaling pathway rapidly recovered in the EtSCT+CCl4-treated groups. The EtSCT+CCl4-treated groups showed a significant decrease in hepatic fibrosis markers including collagen accumulation, MMP-2 expression, TGF-β1 concentration, and phosphorylation of Smad2/3. Moreover, a significant decline in malondialdehyde (MDA) concentration and enhancement of superoxide dismutase (SOD) expression were observed in the EtSCT+CCl4-treated groups. Taken together, these results indicate that EtSCT can protect against hepatic injury induced by CCl4-derived reactive intermediates through the suppression of hepatic apoptosis, inflammation, and fibrosis.

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“…www.chinaphar.com Nair DG et al Acta Pharmacologica Sinica npg hepatoprotective activity against CCl 4 -induced liver damage in male albino rats; again, the active compounds involved are not isolated or characterized [30] . Zhao et al demonstrated the antioxidative and hepatoprotective activities of low molecular fucoidan oligosaccharides (LMFO) isolated from Laminaria japonica in mice with liver injury [31] .…”

Section: Previous Reports On Marine-derived Compounds With Hepato Promentioning

confidence: 99%

“…D'Orazio et al, 2012 [34] Takamatsu et al, 2003 [87] Takamatsu et al, 2003 [87] Silva et al, 2012 [88] D'Orazio et al, 2012 [34] Yeh et al, 2012 [89] He et al, 2013 [90] Liu et al, 2012 [47] Esmat et al, 2013 [30] Althunibat et al, 2013 [91] Zhou et al, 2012 [92] Balaji et al, 2004 [45] Pereira et al, 2011 [82] Hong et al, 2012 [93] Liaw et al, 2010 [94] Baidu et al, 2010 [95] Esmat et al, 2013 [33] Whitehouse & Fairlie [96] Kossuga et al, 2008 [97] Kobayashi et al, 2007 [98] Choi et al, 2013 [50] Pinchuk et al, 2013 [51] Tong et al, 2005 [52] Ku et al, 2013 [99] Huang et al, 2007 [100] Posadas et al, 2013 [101] Posadas et al, 2013 [101] Nagle et al, 2004 [102] Catassi et al, 2006 [103] Sun et al, 2007 [39] Kang et al, 2013 [104] Chao et al, 2008 [105] Cheng et al, 2008 [106] …”

mentioning

confidence: 99%

The use of marine-derived bioactive compounds as potential hepatoprotective agents

2014

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The marine environment may be explored as a rich source for novel drugs. A number of marine-derived compounds have been isolated and identified, and their therapeutic effects and pharmacological profiles are characterized. In the present review, we highlight the recent studies using marine compounds as potential hepatoprotective agents for the treatment of liver fibrotic diseases and discuss the proposed mechanisms of their activities. In addition, we discuss the significance of similar studies in Oman, where the rich marine life provides a potential for the isolation of novel natural, bioactive products that display therapeutic effects on liver diseases.

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Hepatoprotective efficacy of Hypnea muciformis ethanolic extract on CCl4 induced toxicity in rats

Abstract: The ethanolic extract of Hypnea muciformis (red algae) was tested for hepatoprotective activity against experimentally induced liver damage by Carbon tetrachloride (CCl 4

Cited by 7 publications

References 21 publications

Biological properties and potential of compounds extracted from red seaweeds

Biological properties and potential of compounds extracted from red seaweeds

Ethanol extracts collected from the <i>Styela clava</i> tunic alleviate hepatic injury induced by carbon tetrachloride (CCl<sub>4</sub>) through inhibition of hepatic apoptosis, inflammation, and fibrosis

The use of marine-derived bioactive compounds as potential hepatoprotective agents

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