Sodium fluoride does not alter sperm production or sperm morphology in rats

Chioca, Lea Rosa; Müller, Juliane Centeno; Boareto, Ana Cláudia; Andreatini, Roberto; Dalsenter, Paulo Roberto

doi:10.1590/s1516-89132012000200011

Cited by 2 publications

(2 citation statements)

References 20 publications

(28 reference statements)

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“…All these changes leading to a reduction in organs weights, we're in agreement with the results of the Kumar et al (12) and contradicted with the result of the Chioca et al (13) who mentioned that NaF doesn't alter the weights of organs and body weights. The ovary is an significant organ of numerous reproductive toxicants and female rats reproductive functions that exposed to NaF was markedly decrease and destroy, and this effects may have been caused by ovarian abnormality, and due to toxicity exposure to NaF, the histopathological changes in the treated groups showed a decrease in the number of Graafian follicles with increase numbers of growing follicles, in addition to different stage of developing of atretic follicles and these results are in accordance with the Farooqi and Maity et al (14,15) which assign the decrease in the number of Graafian follicles to reduced number of cell, division of it, and to differentiation in germ cell through oogenesis.…”

Section: Discussionsupporting

confidence: 78%

Histological effects of chronic sodium fluoride toxicity on some reproductive organs of male and female adult albino rats

Al-Sabaawy¹,

Al-Kaisie²

2021

IJVS

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The current study aimed to determine the pathological effects of chronic poisoning with sodium fluoride on some reproductive organs like ovary, and testis of adult's male and female albino rats. Thirty-six male and female adult's albino rats were divided into six groups. The first and second group of male and female rats are control groups was given tap drinking water, the third and fourth groups of male and female rats was given 150 ppm of NaF, the fifth and sixth group of male and female rats was given 300 ppm of NaF respectively for 90 days. The weights of male and female genital were recorded. Histological exam of control groups of female rats showed the typical histological structure of the ovary, while the NaF treated groups showed a decrease in growing follicles, in addition to thickening in tunica albuginea and deposition of eosinophilic material. In male control groups, the sections showed the typical histological structures of the testis, while the treated groups showed multinucleated spermatids in addition to the deposition of amorphous eosinophilic material in the interstitial tissue, coagulative necrosis, in addition to apoptotic and sloughed spermatogonia in the lumen of seminiferous tubule. These results indicate that sodium fluoride with 300 ppm has toxic effects on organ body weights and on the histology of the gonads of adult's male and female albino rats.

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Section: Discussionsupporting

confidence: 78%

Histological effects of chronic sodium fluoride toxicity on some reproductive organs of male and female adult albino rats

Al-Sabaawy¹,

Al-Kaisie²

2021

IJVS

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“…30 and Chioka et al. 31 demonstrated the impact of NaF on the male and female reproductive system, focus was on the sperm production and hormones respectively.…”

Section: Discussionmentioning

confidence: 99%

Protective role of resveratrol, a natural polyphenol, in sodium fluoride-induced toxicity inDrosophila melanogaster

Abolaji

Ajala

Adigun

et al. 2019

Exp Biol Med (Maywood)

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Sodium fluoride (NaF) is used in water fluoridation and dental products such as mouth rinses and toothpastes. Resveratrol is a natural polyphenol with antioxidant and anti-inflammatory properties. The present study was carried out to evaluate the toxicity of NaF and the protective role of resveratrol in Drosophila melanogaster. For longevity assay, Harwich strain of D. melanogaster was treated with NaF (0, 10, 30, 50, 70 and 90 mg/kg diet) throughout the lifespan and daily mortality recorded. Then, flies were again treated with similar doses of NaF for seven days to evaluate survival rate and oxidative stress markers. Thereafter, 60 mg resveratrol/kg diet was selected to determine its ameliorative role in NaF (70 mg/kg)-induced toxicity in flies: Group A (control), Group B (60 mg resveratrol/kg diet), Group C (70 mg NaF/kg diet), and Group D (resveratrol, 60 mg/kg diet) + NaF, 70 mg/kg diet). Thereafter, Glutathione-S-transferase (GST), catalase and acetylcholinesterase (AchE) activities, as well as total thiol (T-SH), nitrites/nitrates and hydrogen peroxide (H2O2) levels were determined. The results showed that resveratrol prevented NaF-induced elevation of H2O2 and nitrites/nitrates levels, as well as catalase activity. In addition, resveratrol restored NaF-induced inhibition of GST and AChE activities and depletion of T-SH content ( P < 0.05). Conclusively, resveratrol offered protective benefit against NaF-mediated toxicity in flies due to its antioxidant and anti-inflammatory properties. Impact statement D. melanogaster was used to understand the impact of NaF on lifespan and emergence rate as well as the rescue role of resveratrol. These parameters are difficult to carry out in previously used models such as rodents. This further enforces in part, the suitability of D. melanogaster in studying NaF-induced toxicity and the therapeutic effects of drugs. Additionally, we found that resveratrol rescued D. melanogaster from oxidative stress-induced by sodium fluoride (NaF) administration. This study is of public health significance as it indicated that the consumption of fruits rich in resveratrol such as grapes may offer protective role against inadvertent exposure to NaF and related chemicals.

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Sodium fluoride does not alter sperm production or sperm morphology in rats

Cited by 2 publications

References 20 publications

Histological effects of chronic sodium fluoride toxicity on some reproductive organs of male and female adult albino rats

Histological effects of chronic sodium fluoride toxicity on some reproductive organs of male and female adult albino rats

Protective role of resveratrol, a natural polyphenol, in sodium fluoride-induced toxicity inDrosophila melanogaster

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