Incorporation of n-3 fatty acids by the liver of mice fed linseed oil as a function of feeding duration

Perini, João Angelo Lima; Stevanato, Flávia Braidotti; Visentainer, Jeane Eliete Laguila; Sargi, Sheisa Cyléia; Oliveira, Márcia Machado de; Souza, Nilson Evelázio de; Matsushita, Makoto

doi:10.1590/s1516-89132011000200012

Cited by 6 publications

(7 citation statements)

References 30 publications

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“…On the other hand, in agreement with our results, P e r i n i et al [26] applied flax diet to mice and observed the highest level of ALA in the liver and consequently a significantly increased conversion of ω-3 ALA to EPA and DHA with the highest levels on day 56 of application, accompanied by a significant decrease in the conversion of ω-6 LA to AA and almost a 3-fold decrease in the ω-6:ω-3 PUFA ratio.…”

Section: Discussionsupporting

confidence: 94%

“…sheep [36]. Similar to our study, increased proportions of ω-3 PUFAs were observed in skeletal muscles and adipose tissue, but also in the tissues of heart, liver and brain after increased intake of ALA by feed [13,26,32]. However, they recorded an increased levels of ALA, eventually also EPA and docosapentaenoic acid (DPA), but the content of DHA (the acid important for the organism) was comparable with the control.…”

Section: Health Conditionssupporting

confidence: 85%

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The Influence of Probiotic Lactobacilli and Flaxseed on the Health of Weaned Piglets and Metabolism of Polyunsaturated Fatty Acids (PUFAs)

et al. 2016

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This study investigated for 14 days post-weaning, the influence of dietary supplementation of synbiotics in the form of probiotic cheeses containing cultures of L. plantarum and L. fermentum and crushed flaxseed (source of ω-3 polyunsaturated fatty acids — PUFAs and fibre) on 36 commercial piglets originating from an infected herd (Coronavirus and E. coli) during the critical period of weaning. We focused on the health and metabolism of PUFAs in this critical period of a piglet’s life. The dietary supplementation positively affected: the overall health state of weaners, reduced diarrhoea by 29 % by 14 days post-weaning and significantly increased the counts of lactic acid bacteria, bifidobacteria and the production of volatile fatty acids. The PUFA concentrations in the m. biceps femoris of the piglets were analysed by gas chromatography. High levels of ω-3 alpha-linolenic acid (ALA) in flaxseed increased significantly the level of ALA, eicosapentaenic acid (EPA) and docosahexaenic acid (DHA) in the pig muscles on days 7 and 14 post-weaning. The levels of ω-6 linolenic acid (LA) were less affected by the diet, but were increased on day 14 post-weaning, while the conversion products of LA, and arachidonic acid (AA), were decreased on days 7 and 14. The increased level of dietary ALA favoured the activity of Δ-6-desaturase for the conversion of ALA to EPA and DHA, at the expense of AA synthesis from LA. The ability of synbiotics to incorporate high levels of DHA in the pig muscles appear prospective for improving the nutritional properties of pork and reducing the occurrence of civilization diseases in consumers of this product of animal origin.

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Section: Discussionsupporting

confidence: 94%

Section: Health Conditionssupporting

confidence: 85%

The Influence of Probiotic Lactobacilli and Flaxseed on the Health of Weaned Piglets and Metabolism of Polyunsaturated Fatty Acids (PUFAs)

et al. 2016

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“…Replacement of ARA with n-3 fatty acids in eicosanoid metabolism lowers [3]. ALA-enriched linseed oil diet resulted in increased n-3 fatty acids and decreased n-6 fatty acids in the liver of Swiss mouse [17]. Modification of diet of cows with fish oil and linseed significantly decreased short chain and medium chain fatty acids, and significantly increased PUFA in milk [18].…”

Section: Discussionmentioning

confidence: 97%

Dietary Black Raspberry Seed Oil Ameliorates Inflammatory Activities in db/db Mice

Lee

Jung

Cho

et al. 2016

Lipids

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The objective of this study was to evaluate the status of the markers related to inflammation in db/db mice fed black raspberry seed (BRS) oil, which is rich in α-linolenic acid. Mice were divided into four groups: (1) C57BL/6 mice fed 16 % calories from soybean oil (normal CON); (2) C57BL/KsJ-db/db mice fed 16 % calories from soybean oil (CON); (3) C57BL/KsJ-db/db mice fed 8 % calories from soybean and 8 % calories from BRS oil (BRS 50 %); and (4) C57BL/KsJ-db/db mice fed 16 % calories from BRS oil (BRS 100 %). After 10 weeks, n-6/n-3 fatty acid ratios were significantly (P < 0.05) lower in the livers and epididymal adipose tissues of the BRS 50 % and BRS 100 % mice than in the CON. Serum TNFα and IL-6 were significantly (P < 0.05) lower in the BRS 50 % and BRS 100 % than in the CON. Serum IL-10 was significantly (P < 0.05) higher in the BRS 100 % than the CON. In the liver and epididymal adipose tissue, mRNA levels of pro-inflammatory markers in the BRS 50 % and BRS 100 % were lower than in the CON. Anti-inflammatory markers were higher in the epididymal adipose tissues of the BRS 50 % and BRS 100 % than in the CON. In the epididymal adipose tissue, macrophage infiltration markers (F4/80 and CD68) and leptin mRNA were significantly (P < 0.05) lower in the BRS 50 % and BRS 100 % than in the CON. Results of this study suggest that BRS oil may have anti-inflammatory effects in obese diabetic mice by ameliorating inflammatory responses.

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“…These are essential fatty acids (EFA) as they are not produced by mammals and must be obtained through the diet [2]. LA is metabolized to arachidonic acid (AA, 20:4n-6) and LNA to eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (22:6n-3), and both are converted by the same sequential desaturation and elongation enzyme systems (Δ6-desaturase, Δ5-desaturase, and elongases) during their biosynthesis.…”

Section: Introductionmentioning

confidence: 99%

“…The last few decades have seen increased interest in the potential health effects of omega-3 polyunsaturated fatty acids (n-3 PUFA), especially alpha-linolenic acid (LNA, 18:3n-3), and omega-6 polyunsaturated fatty acids (n-6 PUFA), especially linoleic acid (LA, 18:2n-6) [ 1 ]. These are essential fatty acids (EFA) as they are not produced by mammals and must be obtained through the diet [ 2 ]. LA is metabolized to arachidonic acid (AA, 20:4n-6) and LNA to eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (22:6n-3), and both are converted by the same sequential desaturation and elongation enzyme systems (Δ6-desaturase, Δ5-desaturase, and elongases) during their biosynthesis.…”

Section: Introductionmentioning

confidence: 99%

Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E₂and Nitric Oxide during Experimental Murine Paracoccidioidomycosis

Sargi

Dalálio

Moraes

et al. 2013

BioMed Research International

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There has recently been increased interest in the potential health effects of omega-3 polyunsaturated fatty acids on the immune system. Paracoccidioidomycosis is the most important endemic mycosis in Latin America. Macrophages have a fundamental role and act as first line of organism defense. The purpose of this study was to analyze the effect of n-3 fatty acids on the production of PGE2 and NO by mice infected with Pb18 and fed a diet enriched with LNA for 8 weeks. To study the effect of omega-3 fatty acids on macrophage activity during experimental paracoccidioidomycosis, mice were infected with Pb18 and fed a diet supplemented with LNA. PGE2 in the serum of animals was analyzed and NO in the supernatants of macrophages cultured and challenged in vitro with Pb18 was measured. Omega-3 fatty acids seemed to decrease the production of PGE2 in vivo in the infected group fed an LNA-supplemented diet during the 4th and 8th weeks of the experiment. At the same time, we observed an increase in synthesis of NO by peritoneal macrophages in this group. Omega-3 fatty acids thus appear to have an immunomodulatory effect in paracoccidioidomycosis.

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Incorporation of n-3 fatty acids by the liver of mice fed linseed oil as a function of feeding duration

Cited by 6 publications

References 30 publications

The Influence of Probiotic Lactobacilli and Flaxseed on the Health of Weaned Piglets and Metabolism of Polyunsaturated Fatty Acids (PUFAs)

The Influence of Probiotic Lactobacilli and Flaxseed on the Health of Weaned Piglets and Metabolism of Polyunsaturated Fatty Acids (PUFAs)

Dietary Black Raspberry Seed Oil Ameliorates Inflammatory Activities in db/db Mice

Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E₂and Nitric Oxide during Experimental Murine Paracoccidioidomycosis

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Incorporation of n-3 fatty acids by the liver of mice fed linseed oil as a function of feeding duration

Cited by 6 publications

References 30 publications

The Influence of Probiotic Lactobacilli and Flaxseed on the Health of Weaned Piglets and Metabolism of Polyunsaturated Fatty Acids (PUFAs)

The Influence of Probiotic Lactobacilli and Flaxseed on the Health of Weaned Piglets and Metabolism of Polyunsaturated Fatty Acids (PUFAs)

Dietary Black Raspberry Seed Oil Ameliorates Inflammatory Activities in db/db Mice

Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E2and Nitric Oxide during Experimental Murine Paracoccidioidomycosis

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Product

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Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E₂and Nitric Oxide during Experimental Murine Paracoccidioidomycosis