Influence of cosmetics vehicles on 4-methylbenzylidene-camphor's skin penetration, in vitro

Abstract

The aim of this work was to compare the skin penetration of 4-methylbenzylidene-camphor (4-MBC) in two vehicles, an oil-in-water (O/W) emulsion and an alcoholic gel. The penetration of this UVB filter through these vehicles was determined in vitro (Franz cells) using pig ear skin. The 4-MBC permeated through the skin both with the emulsion o/w as the alcoholic gel. However, with the alcoholic gel, 5 h after application of the product, the 4-MBC was found in the receptor fluid, while with the emulsion o/w, 24 h after it was detected. In both vehicles, the 4-MBC was

Effect of vehicle on the performance of active moisturizing substances

“…There are many types of vehicles and their classification systems can be based on various principles described in the literature . However, it should be mentioned that cosmetics preparations are rather complex systems, where the effect of the vehicle and the active substance cannot be easily separated .…”

4‐Methylbenzylidene camphor microspheres: reconstituted epidermis (Skinethic®) permeation and distribution

“…Recent investigations have shown that in rat as well as in man, 4‐MBC is systematically absorbed after topical application . Some studies showed that 4‐MBC can penetrate through human skin and be excreted in urine .…”