Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy

Pereira, Kércia Regina Santos Gomes; Açucena, Maria Kadja Meneses Torres; Neto, Arthur Villarim; Rêgo, Amália Cínthia Meneses; Bernardo-Filho, Mário; Azevedo, Ítalo Medeiros; Filho, Irami Araújo; Medeiros, Aldo Cunha

doi:10.1590/s1516-89132008000700033

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…Besides the disease, these procedures could be altered by medications, surgery and natural products that could change the biodistribution of radiopharmaceuticals in a specific target or the fixation of Tc to blood constituents 16,18 . In general, the labeling of blood constituents could decrease by the action of …”

Section: Discussionmentioning

confidence: 99%

Metabolic and hematologic consequences of colectomy associated to hepatectomy in rats

Carvalho¹,

Araújo‐Filho²,

Azevedo³

et al. 2011

Acta Cir. Bras.

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PURPOSE:To investigate the influence of partial colectomy associated with hepatectomy on the biodistribution of the 99m Tc-phytate, on metabolic parameters, as well as labeling and morphology of red blood cells. METHODS: Wistar rats were distributed into three groups (each with six), nominated as colectomy, colectomy+hepatectomy and sham. In the 30 th postoperative day all rats were injected with 99mTc-phytate 0.1mL i.v. (radioactivity 0.66 MBq). After 15 minutes, liver sample was harvested and weighed. Percentage radioactivity per gram of tissue (%ATI/g) was determined using an automatic gammacounter. Serum AST, ALT, alkaline phosphatase and red blood cells labeling were determined. RESULTS: The liver %ATI/g and red blood cells labeling were lower in colectomy and colectomy+hepatectomy rats than in sham rats (p <0.05), and no difference was detected comparing the colectomy and colectomy+hepatectomy groups. Red blood cells morphology did not differ among groups. Serum levels of AST, ALT and alkaline fosfatase were significantly higher in colectomy+hepatectomy than in colectomy rats (p<0.001). CONCLUSION: Hepatectomy associated with colectomy lowered the uptake of radiopharmaceutical in liver and in red blood cells in rats, coinciding with changes in liver enzymatic activity. Keywords: Colectomy. Hepatectomy. Metabolism. Biological Availability. Technetium. Rats. RESUMO OBJETIVO:Investigar a influência da colectomia associada à hepatectomia parcial, na biodistribuição do fitato99m TcO 4 , na marcação e morfologia de hemácias e em parâmetros metabólicos. MÉTODOS: Ratos Wistar foram distribuídos em três grupos (seis animais cada), denominados: colectomia, colectomia+hepatectomia e sham. No 30º dia pós-operatório, em todos eles foi feita injeção de 0,1 mL i.v. de fitato-

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Section: Discussionmentioning

confidence: 99%

Metabolic and hematologic consequences of colectomy associated to hepatectomy in rats

Carvalho¹,

Araújo‐Filho²,

Azevedo³

et al. 2011

Acta Cir. Bras.

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“…The radiopharmaceutical 99mTc-phytate is used as evidence of hepatic function and in the diagnosis of liver disease through imaging tests, depending on its biodistribution 7 . A recent study in rats showed that splenectomy caused changes in the uptake of 99mTcphytate by the liver, coinciding with deterioration of liver function 13 .…”

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confidence: 99%

Efeitos do óleo de andiroba (Carapa guianensis) na função hepática de ratos submetidos à isquemia e reperfusão normotérmica do fígado

Brito

Junior

Leão

et al. 2013

Rev. Col. Bras. Cir.

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“…Biodistribution to the liver and bone marrow has shown good correlation with the severity of liver diseases such as cirrhosis and fibrosis of the organs and its prognosis. Thus, quantification of the uptake of 99m Tc-sodium phytate serves as an excellent index of liver function (Groshar et al, 2002;Pereira et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Influence of sweeteners in the biodistribution of radiopharmaceutical and laboratory tests in rats

Queiroz¹,

Barbosa²,

Holanda³

et al. 2016

Afr. J. Biotechnol.

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This study aimed to evaluate the effect of supplementation of sucralose and fructose on the metabolism of adolescent rats. Eighteen male Wistar rats were divided into 3 groups: control group (GC), fructose group (GF) treated with 50 mg/kg of fructose, and sucralose group (GS) receiving 50 mg/kg of sucralose for 24 days. The weight and feed intake were measured weekly. At the end of the experiment, some biochemical parameters, histopathology of the liver and biodistribution of the radiotracer 99m Tc-sodium phytate in liver and blood were analyzed. The GF showed higher body weight only in the first week compared with GS and GC (p<0.05). Histopathology and % ATI/g radiotracer 99m Tc-sodium phytate in liver and blood were not different between the groups. The GF showed higher values of aspartate aminotransferase activity, bilirubin, alkaline phosphatase activity and gamma glutamyl transferase activity, compared with the other groups (GC and GS) (p<0.05). Activity of alanine aminotransferase and albumin level of GF were higher than GS (p<0.05). For other parameters, no statistical difference was observed. It was concluded that the use of fructose during the experiment was able to alter hepatic enzymes, but on the other hands, the use of sucralose caused no change.

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Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy

Abstract: ABSTRACT

Cited by 4 publications

References 18 publications

Metabolic and hematologic consequences of colectomy associated to hepatectomy in rats

Metabolic and hematologic consequences of colectomy associated to hepatectomy in rats

Efeitos do óleo de andiroba (Carapa guianensis) na função hepática de ratos submetidos à isquemia e reperfusão normotérmica do fígado

Influence of sweeteners in the biodistribution of radiopharmaceutical and laboratory tests in rats

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