Effect of tripanosomicide benznidazole (Rochagan®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats

Abstract

Benznidazole, a drug with specific anti-Trypanosoma cruzi activity, is used in the treatment of Chagas' disease. The radiopharmaceutical sodium pertechnetate (Na99mTcO4) is used to obtain diagnostic images of the stomach, thyroid, parathyroids, salivary glands, brain and in the study of esophageal reflux and blood flow. This study aimed at evaluating in vivo the influence of benznidazole treatment on the sodium pertechnetate biodistribution in Wistar rats. The percentage of radioactivity per gram (%ATI/g) of various organs (brain, heart, esophagus, stomach, small intestine, large intestine, spleen, liver, muscle and blood) was determined. Comparing the treated rats with the controls, we observed that sodium pertechnetate biodistribution did not change when administered to rats treated for thirty days with benznidazole.<br>O benzonidazol é um quimioterápico com atividade específica anti-T. cruzi utilizado por milhares de pessoas para tratamento da doença de Chagas. O radiofármaco pertecnetato de sódio (Na99mTcO4) é utilizado na obtenção de imagens diagnósticas do estômago, tireóide, paratireóides, glândulas salivares, plexo coróide, cérebro e de estudos de refluxo esofágico e de fluxo sanguíneo. Esse trabalho objetivou avaliar in vivo a influência do tratamento crônico com o benzonidazol na biodistribuição do radiofármaco pertecnetato de sódio em ratos Wistar. O percentual de radioatividade por grama (%ATI/g) de vários órgãos (cérebro, coração, esôfago, estômago, intestino delgado, intestino grosso, baço, fígado, músculo e sangue) foi determinado. Comparando-se o grupo controle e o tratado observou-se que o pertecnetato de sódio não possui sua biodistribuição alterada quando administrado em ratos tratados por trinta dias com a droga benzonidazol, mostrando não prejudicar a interpretação de diagnósticos por imagem

Influence of Annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats

“…Several experimental models have been used to evaluate the properties of synthetic and natural drugs [6][7][8] . The biodistribution of radiopharmaceuticals in the animal organism can be changed with concomitant use of drugs natural and/or synthetic, certain diets, parasitic infections, the use of cigarettes and surgery, as demonstrated in studies described by Araújo-Filho et al 15 and Rêgo et al 16 .…”

“…In the applications in nuclear medicine diagnostic, the isotope technetium-99m ( 99m Tc) has preferred choice. Technetium-99m may bind to different substrates or ligands, resulting radiopharmaceuticals with affinity for different organs, systems or receptors in the body [6][7][8] . Technetium-99m in the form of sodium pertechnetate, or labeled with other structures, such as sodium phytate ( 99m Tc-sodium phytate) or dimercaptosuccinic acid ( 99m Tc-DMSA) are the most frequently used radiopharmaceuticals in nuclear medicine 9 .…”

The malarial infection can alter the normal biodistribution of a radiopharmaceutical?

“…The biological behavior of radiopharmaceuticals used for diagnosis in nuclear medicine is well established in the scientific literature. There is evidence that radiopharmaceutical biodistribution may be altered by infectious diseases, procedures, cigarette smoking, surgery, food or natural and synthetic drugs [20][21][22][23][24] . The present study demonstrated that the uptake of Na 99m TcO 4 was not altered…”