Effects of Chrysobalanus icaco on the labeling of blood constituents with technetium-99m and on the shape of the red blood cells

Abstract

Chrysobalanus icaco (abajeru; C.icaco) is recommended in the treatment of diabetes and other clinical disorders. Blood constituents labeled with technetium-99m (99mTc) are used in nuclear medicine. The aim of this study was to verify the effects of an abajeru extract on the labeling of blood constituents with 99mTc and on the shape of red blood cells (RBC). Blood samples(Wistar rats) were incubated with abajeru extract and the labeling of blood constituents with 99mTc and morphology of RBC were carried out. The results showed significant (P<0.05) alteration of labeling of blood constituents with 99mTc and the morphometry (perimeter/area ratio) of the RBC in presence of the extract. These data suggest that this abajeru extract could alter the labeling of blood constituents with 99mTc by its chelating/antioxidant action and/or effects on membrane structures involved in the ion transport.<br>Chrysobalanus icaco (abajeru; C.icaco) é recomendado para tratar diabetes e outras desordens clínicas. Constituintes sangüíneos marcados com tecnécio -99m (99mTc) são usados em medicina nuclear. O objetivo desse estudo foi verificar os efeitos de um extrato de abajetu na radiomarcação de constituintes sangüíneos com 99mTc e na forma de células vermelhas do sangue (RBC). Amostras de sangue retiradas de ratos Wistar foram incubadas com extrato de abajeru e a marcação dos constituintes sanguíneos com 99mTc e a morfologia das RBC foram realizadas. Os resultados mostraram alteração significativa (P<0.05) da marcação dos constituintes sangüíneos com 99mTc e a morfometria (relação perímetro/área) das RBC na presença do extrato. Esses resultados sugerem que esse extrato de abajeru poderia alterar a marcação de constituintes sangüíneos com 99mTc pela sua ação quelante/antioxidante e/ou seus efeitos nas estruturas de membrana envolvidas no transporte de íons

Chemotaxonomic study ofChrysobalanus icacoLinnaeus (Chrysobalanaceae) using ultra-high performance liquid chromatography coupled with diode array detection fingerprint in combination with multivariate analysis

“…The antidiabetic effect of C. icaco extracts has been investigated , as well as its anti‐inflammatory and antinociceptive , antileishmanial , antioxidant , genotoxic , antimicrobial , anti‐HIV , antiangiogenic , anti‐cancer and anti‐multidrug resistance properties and for preventing weight gain . Phytochemical studies have also reported the presence of flavonoids and terpenoids, which are pharmacologically important chemical groups .…”

Aqueous extract of Chrysobalanus icaco leaves, in lower doses, prevent fat gain in obese high-fat fed mice

“…Phytochemical studies have demonstrated the presence of flavonoids (polyphenols) such as rutin, myricitrin, and quercitrin, as well as other myricetin and quercetin derivatives in the aqueous and hydroalcoholic extracts of its leaves (Barbosa et al 2006). Based on folk medicine, its leaves infusion are traditionally used as a hypoglycemic and diuretic agent (Presta et al 2007). …”

Ethnobotany of Bajiru (Chrysobalanus Icaco L.) In a Coastal Vegetation of Southeastern Brazil

“…However, as this plant occurs along part of the long Brazilian coast (ca. 7,000 km) there are still few studies detailing the ethnobotanical uses of C. icaco [13,18], despite extensive literature proving its food potential, as fruit whose nutritional value is relevant, rich in minerals -chromium, selenium, calcium and iron [1] and hypoglycemic properties in its leaves, being used in traditional medicine of Brazil [31,30,38]. We also highlight records for leukorrhea, bleeding and chronic diarrhea treatment [26,24], antimicrobial activity [11], presence of triterpenes in their leaves, leading to antitumor activity in leukemia cell lines [11].…”