Thyroid cell irradiation by radioiodines: a new Monte Carlo electron track-structure code

Abstract

The most significant impact of the Chernobyl accident is the increased incidence of thyroid cancer among children who were exposed to short-lived radioiodines and 131-iodine. In order to accurately estimate the radiation dose provided by these radioiodines, it is necessary to know where iodine is incorporated. To do that, the distribution at the cellular level of newly organified iodine in the immature rat thyroid was performed using secondary ion mass microscopy (NanoSIMS 50

Tracking microbial interactions with NanoSIMS

“…The nanoSIP combination has been broadly used in cell biology [10,[21][22][23][24][25][26][27], microbiology [2,[28][29][30] and phytoecology [31][32][33][34] (Fig. 1).…”

In Situ Imaging of Metals in Cells and Tissues

“…NanoSIMS is therefore well suited for imaging trace quantities of elements in a complex biological environment for elucidating metabolic pathways of living systems. Taking advantage of the high sensitivity, NanoSIMS has been also applied in numerous isotope tracer studies, for example, for studying the incorporation of iodine in thyroid, , the cellular distribution of melanoma targeting agents, iodobenzamide, , and the uptake of 131 I-labeled drugs in melanoma for developing a targeted radionuclide therapy . The improved spatial resolution and sensitivity of nanoSIMS enabled imaging of uptake of isotopically labeled compounds in bacterial cells − and diatoms , at the single-cell level in order to understand microbial metabolism and to identify associated subcellular structures .…”

Advances in Imaging Secondary Ion Mass Spectrometry for Biological Samples

“…Approximately one-quarter of the publications fall in the category of studies of metabolic pathways (4,17,25,40,56,60,89,90,95). Several studies have demonstrated the value of NanoSIMS for tracer studies, including 13 C-labeled free fatty acid transport across cell membranes (56), thyroid uptake of iodine (17,25), and cellular uptake and distribution of an 15 N-labeled peptide vector (95). Lechene et al (60) provide an extensive exposition of the use of stable isotopes for cell biology.…”