Preparation and evaluation of modified composition for lyophilized kits of [Cu(MIBI)4]BF4 for [99mTc] technetium labeling

Lima, Marisa de Jesus de C.; Marques, Fábio Luiz Navarro; Okamoto, Miriam Roseli Yoshie; Garcez, Alexandre Tales; Sapienza, Marcelo Tatit; Buchpiguel, Carlos Alberto

doi:10.1590/s1516-89132005000700001

Cited by 8 publications

(4 citation statements)

References 16 publications

(23 reference statements)

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“…The microwave heating method has been recommended as an alternative modality for the preparation Sestamibi radiotracer. This technique has been introduced not only for synthesis of Sestamibi ( Lima et al, 2005) but also for labeling of Sestamibi by technetium 99m radioisotope (Gagnon et al, 1991;Hung et al, 1991). When microwave irradiation was used as heating source, the required time for the preparation radiotracer complex samples was reduced to 10 seconds.…”

Section: Discussionmentioning

confidence: 99%

The stability of 99mTc-MIBI (Sestamibi) complex samples which prepared under ultrasound irradiation technique versus boiling water bath method

Doroudi¹,

Saraji²,

Erfani³

et al. 2016

J App Pharm Sci

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Objectives:The main propose of this investigation is to evaluate the value of ultrasound irradiation technique versus boiling water bath in the reconstitution cold MIBI (Sestamibi) kits by technetium 99m. Material and Methods: Twenty Sestamibi cold kits from various batches have been chosen. The vials were randomly divided into two equal groups. The first group was reconstituted by boiling water bath as standard method and the other group reconstituted by new developed technique. The stability of radio-complex samples were examined by thin layer chromatography (ITLC) and Radio high pressure liquid chromatography (Radio-HPLC) up to 24 hours post reconstitution. The partition coefficient and protein bonding of radiotracer samples were analyzed. Results: The significant differences have not been observed in the yields and stability of radiotracer samples which were prepared by either two methods in ITLC and Radio-HPLC investigations. The partition coefficient and protein bonding assays demonstrated that radiotracer samples which were prepared by boiling water bath were a little more lipophilic than the radio-complex samples which were reconstituted by new developed technique. Conclusion: Green chemistry is convenient and efficient modality to reconstitute the cold Sestamibi kit by technetium 99m. It can be established as an alternative method to prepared 99m Tc-Sestamibi in the clinical practice.

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Section: Discussionmentioning

confidence: 99%

The stability of 99mTc-MIBI (Sestamibi) complex samples which prepared under ultrasound irradiation technique versus boiling water bath method

Doroudi¹,

Saraji²,

Erfani³

et al. 2016

J App Pharm Sci

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“…It takes approximately 20 s of heating time in an MW oven (450 W) to make the overall reaction with an average RCP of 97% (this reaction time was later reduced to 10 s) [92,93]. The MW heating was also proposed for the synthesis of tetrakis(2-methylisobutylisonitrile)copper(I) tetrafluoroborate (in a domestic microwave oven at 240 W for 25 s in 68% yield) [94]. Another radiochemical tracer is 99m Tc bicisate (bicisate = N,N -1,2-ethylene-di-yl-bis-L-cysteinate diethyl ester).…”

Section: Technetium-99m and Rheniummentioning

confidence: 99%

Microwave-Assisted Synthesis: Can Transition Metal Complexes Take Advantage of This “Green” Method?

Gabano

Ravera

2022

Molecules

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Microwave-assisted synthesis is considered environmental-friendly and, therefore, in agreement with the principles of green chemistry. This form of energy has been employed extensively and successfully in organic synthesis also in the case of metal-catalyzed synthetic procedures. However, it has been less widely exploited in the synthesis of metal complexes. As microwave irradiation has been proving its utility as both a time-saving procedure and an alternative way to carry on tricky transformations, its use can help inorganic chemists, too. This review focuses on the use of microwave irradiation in the preparation of transition metal complexes and organometallic compounds and also includes new, unpublished results. The syntheses of the compounds are described following the group of the periodic table to which the contained metal belongs. A general overview of the results from over 150 papers points out that microwaves can be a useful synthetic tool for inorganic chemists, reducing dramatically the reaction times with respect to traditional heating. This is often accompanied by a more limited risk of decomposition of reagents or products by an increase in yield, purity, and (sometimes) selectivity. In any case, thermal control is operative, whereas nonthermal or specific microwave effects seem to be absent.

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“…If the radiolabeling reaction is carried out in milder condition or shorter time especially in emergency situations, it can be considered as a significant measure in clinical practice. The use of microwave wavelengths was also proposed for the synthesis of methoxy isobutyl isocyanate (MIBI) and for the preparation of 99m Tc-MIBI (Sestamibi) radiotracer 28 . Despite the fact that radiolabeling reaction of MIBI with 99m Tc was carried out in shorter time in comparison to boiling water bath method, this modality is not commonly used for radiopharmaceutical works due to the following limitations.…”

Section: Mmentioning

confidence: 99%

The Preparation of 99mTc-MAG3 radiotracer by Ultrasound

Doroudi¹,

Falavarjani²,

Khodayar³

et al. 2018

IJPTR

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:The main aim of this investigation was to prepare 99m Tc-MAG 3 samples under sonication. Then the radio complex samples were compared with the counterparts which prepared by boiling water bath as the standard method from the aspects of stability in normal saline, human serum, partition coefficient, protein bonding and finally the biodistribution in rat.The preparation of 99m Tc-MAG 3 samples was examined to determine the ideal condition under sonication that radio complex samples could be prepared with appropriate radiochemical purity. The stability of radiotracer samples was assessed in normal saline up to 24 h post preparation. The partition coefficient, protein bonding and stability in human serum were analyzed. Then the biodistribution of radiotracer samples were evaluated in rat.The Radio-HPLC and ITLC assays indicated that the 99m Tc-MAG 3 samples could be successfully prepared with suitable yields by sonication. The radiolabeling efficiency was above the 90% when the reaction was carried out at 60°C for 1 min. The radio complex samples showed good stability in normal saline and human serum. The partition coefficient and protein bonding were -2.4± 0.32 and 35.23± 1.15 respectively when the radiolabeling was performed by the standard method. These values were -2.51± 0.42 and 39.36± 1.7 when the radiolabeling was undertaken by sonication. The biodistribution of 99m Tc-MAG 3 samples in the rats demonstrated that the radiolabeling procedure could not lead to a significant difference in the biodistribution of samples. The new developed technique can be recommended as an alternative for boiling water bath method to prepare 99m Tc-MAG 3 .

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Preparation and evaluation of modified composition for lyophilized kits of [Cu(MIBI)4]BF4 for [99mTc] technetium labeling

Abstract: The [Cu(MIBI) 4

Cited by 8 publications

References 16 publications

The stability of 99mTc-MIBI (Sestamibi) complex samples which prepared under ultrasound irradiation technique versus boiling water bath method

The stability of 99mTc-MIBI (Sestamibi) complex samples which prepared under ultrasound irradiation technique versus boiling water bath method

Microwave-Assisted Synthesis: Can Transition Metal Complexes Take Advantage of This “Green” Method?

The Preparation of 99mTc-MAG3 radiotracer by Ultrasound

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