Radiopharmaceuticals for sentinel node detection

Abstract

Imaging of sentinel nodes is a valuable technique in the management of some types of cancer. Several different radiopharmaceuticals have been successfully employed in the technique, but there have been few systematic studies to examine the relationship between physicochemical properties of the radiopharmaceuticals used and in-vivo performance. The present study describes the preparation and characterisation of radiocolloids of similar chemical composition but differing in particle size distribution in an attempt to identify the role of variations in the single parameter of size.<br>A imagem de nódulos sentinelas é uma técnica valiosa no acompanhamento de alguns tipos de câncer. Com esta finalidade diferentes radiofármacos têm sido empregados com sucesso, porém existem poucos estudos sistemáticos examinando a relação entre as propriedades físico-químicas dos radiofármacos utilizados e sua performance in vivo. O presente estudo descreve a preparação e caracterização de radiocolóides com composição química similar diferindo sua distribuição no tamanho das partículas; na tentativa de identificar a importância de variações de tamanho como um único parâmetro

99mTc‐human serum albumin nanocolloids: particle sizing and radioactivity distribution

“…There are some levels of uncertainty in the use of particle sizing techniques, for example, which is the ‘real’ definition of particle size (as in a DLS measurement, what is measured is a hydrodynamic mean radius that includes the hydration sphere of a nanoparticle and is an average of the encumbrance when non‐spherical particles are considered), the variety of particle sizing techniques that measure different parameters that are not directly comparable, the discrepancy between physical measurements of particle size and measurements of the distribution of radioactivity. Also Frier suggested that particle sizing data cannot easily be compared between different radiopharmaceuticals, and further systematic investigations are required.…”

Sentinel Lymph Node Mapping in Melanoma with Technetium-99m Dextran

“…6 There has been experience with different radiopharmaceuticals for lymphoscintigraphy. 7 Actually, Tc99m human serum albumin and filtered Tc99m sulfur colloid are the most widely used in the detection of sentinel node, specially in cutaneous lesions like melanoma and also in breast cancer, where lymph node involvement is a prognostic factor.…”