Infection imaging with radiopharmaceuticals in the 21st century

Das, Sreena; Hall, Anne V.; Wareham, David W.; Britton, K. E.

doi:10.1590/s1516-89132002000500005

Cited by 55 publications

(39 citation statements)

References 29 publications

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“…1970'lerin başlarından 1980'lerin ortalarına kadar Ga-67 sitrat kas-iskelet sistemi enfeksiyon ve enflamasyonlarını görüntülemede tercih edilen başlıca radyofarmasötik olmuştur (13,14).…”

Section: Galyum-67sitratunclassified

“…Ga-67, tıpki analoğu olduğu demir gibi sideroforlara yoğun bağlanma gösterir. Ga-67 enfekte dokularda düşük demir seviyeli ortamlarda mikroorganizmalar tarafından üretilen sideroforlar tarafından tıpkı demirmiş gibi alınır ve hücre içine taşınır (13,16,17,18). Biyolojik yarı ömrü transferin, haptoglobin, albumin ve globulin gibi serum proteinlerine bağlandığından 2-3 haftayı bulur.…”

Section: Ga-67sitratbiyodağılımıvetutulummekanizmasıunclassified

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Sentinel Lymph Node Imaging and Biopsy in Breast Cancer

Acar¹,

Sevinç²,

Bekiş³

2017

Nts

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Enfeksiyon-Enflamasyon: Moleküler Görüntülemede Kullanılan SPECT RadyofarmasötikleriFunctional and metabolic Nuclear medicine imaging techniques demonstrate infectious as well as inflammed foci before the presence of any anatomical sign. Numerous techniques have been developed for scintigraphic visualisation of infection and inflammation for a period of more than a half century. Specific as well as nonspecific radiopharmaceuticals have been utilised. The uptake mechanisms of non-specific agents are mostly dependant on changes in vascular permeability. That's why it is not possible to distinguish infection and inlammation using non-specific agents. Ga-67 citrate can also be used for diagnosis of infection in several pathological cases. The uptake mechanism of Ga-67 citrate in infectious foci is dependent on many factors but binding to transferin in the circulating blood is the initial step. On the other hand In-111 oxin or Tc-99m labelled immunoglobulin are accumulated at the infection site with the activation of Fc-ɣ receptors in the leukocytes. Although In-111 and Tc99m labelled leukocyte scıntigraphy have been developed in the 1970s, this method has been still a golden one. As the isolation and labelling process of luekocytes is time consuming and involved some risk factors, the researches have been investigating ways to develop spesific agents which will trap in leucosite in vivo. Tc-99m and I-123 labelled antigranulocyte antibodies, peptides, cytokines, all of which will target and bind leukocyte receptors have been used to visualise infections. Additionally antibiotics and antimicrobial peptides have been labelled with radionuclides in vivo, in order to carry out spesific visualisation techniques.

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Section: Galyum-67sitratunclassified

Section: Ga-67sitratbiyodağılımıvetutulummekanizmasıunclassified

Sentinel Lymph Node Imaging and Biopsy in Breast Cancer

Acar¹,

Sevinç²,

Bekiş³

2017

Nts

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“…Recently, Welling, et al reported several radiopharmaceutical that potentially used to detect infections (Welling., 2009). In addition, several studies reported that 99m Tc as an imaging agent for infections have used in some cases (Dass et al, 2002), for instance, by Awaludin and colleagues (Awaludin, 2011). In their review, they showed that 99m Tc is widely used in nuclear medicine, including for imaging infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

Biological Safety Evaluation of 99mTc-DTPA-Ketoconazole for Diagnosis of Fungal Infection

Sriyani

Wongso

Widyasari

et al. 2017

ijpna

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Infectious diseases have become one of the leading cause of mortality around the world, including in the Southeast Asia. One of the microbial that cause infection is fungi. Occasionally, deep-seated fungal infection is difficult to detect using conventional diagnosis methods and therefore leads to inaccurate detection. Our previous research was conducted in order to obtain the labeled compound of 99m Tc-DTPA-Ketoconazole with a high radiochemical purity (98.40 ± 0.86%). Moreover, the in-vitro assays showed that 99m Tc-DTPA-Ketoconazole can potentially bind to Candida albicans. On the other hand, in clinical routine use, diagnostic kit should be safe for the patients. Consequently, this research was conducted to determine the biological safety parameters of 99m Tc-DTPA-Ketoconazole on the animal study, including single dose and acute toxicity test, sterility, and apirogenicity test. The results showed that both the single dose at 34.6 μCi and dose until 149 times of the single dose did not stimulate the toxic response to the animals. In addition, the sterility data revealed that there was no microbial growth after 7 days of incubation at 37°C as well as fungal growth after 14 days of incubation at 25°C. Furthermore, the apirogenicity test using rabbits revealed that there was no increase in temperature more than 0.6°C for each animal and not more than 1.5°C of total increase of temperature for all the animals. It is concluded that the 99m Tc-DTPA-Ketoconazole is satisfy the requirements of biological safety of a radiopharmaceutical and therefore was acceptable for fungal detection in nuclear medicine.

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“…Clinicians use a variety of laboratory, clinical, pathological, and radiological tests to aid diagnosis and make a decision. Although radiological techniques such as X-ray, ultrasound, computerized tomography, and magnetic resonance imaging are commonly used, these techniques are of limited use due to insignificant anatomical changes in the early stages of the infection process (Das et al, 2002;El-Ghany et al, 2005a).…”

Section: Introductionmentioning

confidence: 99%

Technetium-99m labeled Mebendazole and biodistribution in experimentally Trichinella spiralis-infected rats

et al. 2011

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The aim of this study was to localize the biodistribution of Technetium-99m ( 99m Tc) Mebendazole in experimentally Trichinella spiralis (T. spiralis)-infected rats. Localizing and distinguishing the ''T. spiralis'' in body sites are very important and life saving processes. Scintigraphic detections may help to determine the sites of trichinellosis infection. Twelve healthy female Wistar rats were infected via oral administration of infected muscle containing 750 to 1000 larvae. In this study, the antibiotic was labeled with Tc-99m, and 99m Tc-Mebendazole was assessed as an infection imaging agent in a rat model. 99m Tc-mebendazole was examined for localizing the normal, and inflamed with trichinellosis in rat muscle tissues after administrated 99m Tc-mebendazole via intravenous (IV) or oral gastric catheter, and also for differentiating them from each other. 99m Tc labeled mebendazole was retained in infectious areas. It was established that 99m Tc-mebendazole which was administrated via IV route has high organ restrain level. It was observed that 99m Tc-mebendazole uptake was high in tongue and diaphragm muscles of T. spiralis-infected rats after administration of radiolabeled mebendazole via either oral or IV routes. This study may be viewed as a basement of future studies on diagnosis of T. spiralis infection.

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Infection imaging with radiopharmaceuticals in the 21st century

Cited by 55 publications

References 29 publications

Sentinel Lymph Node Imaging and Biopsy in Breast Cancer

Sentinel Lymph Node Imaging and Biopsy in Breast Cancer

Biological Safety Evaluation of 99mTc-DTPA-Ketoconazole for Diagnosis of Fungal Infection

Technetium-99m labeled Mebendazole and biodistribution in experimentally Trichinella spiralis-infected rats

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