Heterozigose para hemoglobinopatias em doadores de sangue do Centro de Hemoterapia de Sergipe

Vivas, Wanessa L. P.; Rebouças, Danilo S.; Fabbro, Amaury Lélis Dal; Cipolotti, Rosana

doi:10.1590/s1516-84842006000400013

Cited by 7 publications

(11 citation statements)

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“…There were 186 patients in list C alone (older patients) and 188 appearing in the overlaps and the other lists, demonstrating that within our study population, approximately 50% of patients may represent a relatively milder disease course. Furthermore, a study of haemoglobinopathies among blood donors in Sergipe reported a prevalence of HbAS sickle cell trait of 4.1% (Vivas et al. 2006).…”

Section: Discussionmentioning

confidence: 99%

Estimating the post-neonatal prevalence of sickle cell disease in a Brazilian Population

Ilozue

Cipolotti

Melo

et al. 2010

Tropical Medicine &Amp; International Health

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Summaryobjective To estimate the prevalence of individuals with sickle cell disease (SCD) in Aracaju, Brazil, using the capture-recapture (CRC) method. SCD is a significant public health problem with long-term life-threatening complications. There are no reliable estimates of the number of individuals with this condition in Aracaju, north-east Brazil. The CRC method has been used to quantify other ubiquitous populations.method Three independent lists of individuals with homozygous (HbSS) SCD were constructed from patients attending the main specialist ambulatory service, all patients with SCD admitted to three government hospitals and a clinic providing specialist immunisation services to patients with SCD. Individuals were matched to ascertain whether they appeared in one, two or three lists, and population size was estimated using the log-linear model.results The lists identified 374 individuals. Two hundred and one appeared in one, 99 in two and 74 in three lists with an estimated number 400 (95% CI 387-418) HbSS SCD individuals; 51.6% patients with SCD were men and age ranged from 1-62 years (median 14).conclusion The CRC method resulted in a smaller population estimate than expected. The causes of this discrepancy may include list dependence, high mortality with a survival cohort effect and the method of identifying the more severe cases. The CRC method has potential to estimate the size of this population and could supplement neonatal screening to further characterise the SCD population in this region.

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Section: Discussionmentioning

confidence: 99%

Estimating the post-neonatal prevalence of sickle cell disease in a Brazilian Population

Ilozue

Cipolotti

Melo

et al. 2010

Tropical Medicine &Amp; International Health

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“…Eight studies were selected. 7,[12][13][14][15][16][17][18] The articles were published during the last 12 years, with varying sample sizes, involving adult blood donors from different countries. 7,14,16,18 For the detection of the presence of HbS, electrophoresis in alkaline pH was commonly used (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…The scientific literature has few studies about the prevalence of sickle cell trait in blood donors. 7,[12][13][14][15][16][17][18] However, a cross-sectional design, 19 appropriate to the proposed objectives of the majority of studies that have already done, presented a simple methodology and of high quality.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of sickle cell trait in blood donors: A systematic review

Machado

Gomes

Oliveira

et al. 2019

BJHBS

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Introduction: The sickle cell trait is a genetic mutation characterizedby the presence of hemoglobin S (HbS) in heterozygosisin which patients are asymptomatic, which makesthem suitable for blood donation. Aim: Systematizing datarelated to the prevalence of the sickle cell trait among blooddonors. Materials and methods: A search of the literature wasconducted in May 2019 to seek articles published from 1990and which had available online abstracts, in four electronicdatabases. Studies were selected with the following characteristics:(1) original work; (2) observational; (3) developed withblood donors; and (4) showing prevalence of sickle cell trait.Two independent reviewers identified the articles for inclusionin this systematic review of the literature (SRL), extractedthe pre-determined data and carried out the evaluation of theworks’ methodological quality. Results: Eight studies publishedin the last 12 years in different countries were selected totake part in this SRL. With variable sample size, all presented across-sectional methodology. For the detection of the presenceof HbS, electrophoresis in alkaline pH was commonly used.The statistical analysis developed involved simple techniques,showing that the prevalence of blood donors with sickle celltrait ranged from 0.4% to 20.8%. The majority of studies wasconsidered of high methodological quality. Conclusion: Theprevalence of sickle cell trait among blood donors varies widely,although it may not be moderate, given that the screeningof HbS has important clinical significance for the proper useof this blood component.Keywords: Sickle cell trait; Blood donor; Blood transfusion.

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“…In this region, there is a high prevalence of the hemoglobin S gene because of the ethnic composition of the population (10) . For the purposes of the present study, eligible patients were those with SCA confirmed by means of hemoglobin electrophoresis and had already undergone blood transfusion.…”

Section: Methodsmentioning

confidence: 99%

Sobrecarga de ferro transfusional em portadores de anemia falciforme: comparação entre ressonância magnética e ferritina sérica

Filho¹,

Ferrão

França

et al. 2011

Radiol Bras

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Objective: To identify predictive variables of iron overload in patients with sickle cell anemia, correlating biochemical and imaging markers. Materials and Methods: The authors developed a cross-sectional study involving 32 patients with sickle cell anemia who were evaluated for ferritin and iron serum levels and submitted to liver magnetic resonance imaging with one spin-echo and five gradient-echo sequences. The signal intensity was obtained at each sequence, corresponding to the arithmetical mean of the measurements on regions of interest in the liver and paraspinal muscles to obtain the liver/muscle signal intensity ratio (SIR). Based on such SIR, the liver iron concentration (LIC) was estimated by means of the following formula: e [5.808 -(0.877 × T2*) -(1.518 × IW)] , where T2* is the SIR on the sequence with echo time = 13 ms and IW is the SIR on the intermediate-weighted sequence. Patients were grouped according to their blood transfusion regimen (regular monthly versus sporadic transfusions). Results: The comparison between the transfusion groups was based on clinical-laboratory variables, with significant differences in SIR, LIC and serum ferritin levels: the group with regular transfusions demonstrated greater hepatic iron overload. Conclusion: Magnetic resonance imaging is an efficient tool for evaluating liver iron overload in patients with sickle cell anemia. Keywords: Sickle cell anemia; Magnetic resonance imaging; Ferritin.Objetivo: Identificar variáveis preditoras de sobrecarga de ferro em portadores de anemia falciforme e correlacionar indicadores bioquímicos e imaginológicos. Materiais e Métodos: Foi realizado estudo transversal envolvendo 32 portadores de anemia falciforme, que foram submetidos a dosagem sérica de ferro, ferritina e a ressonância magné-tica do fígado. Foram realizadas cinco sequências gradiente-eco e uma spin-eco. A intensidade de sinal foi obtida em cada sequência pelas médias das regiões de interesse no fígado e musculatura paravertebral para obter a razão da intensidade de sinal (RIS) fígado/músculo. A partir da RIS foi obtida a concentração hepática estimada de ferro (CHEF) pela fórmula: e [5,808 -(0,877 × T2*) -(1,518 × PI)] , onde T2* é a RIS na sequência com TE de 13 ms e PI é a RIS da sequência com ponderação intermediária. Os pacientes foram agrupados segundo o regime de transfusão de hemácias (regulares mensais versus esporádicas). Resultados: Os grupos transfusionais foram comparados pelas variáveis clínico-laboratoriais, sendo significativas as diferenças entre RIS, CHEF e ferritina sérica: o grupo que recebeu transfusões regulares apresentou sobrecarga de ferro hepático mais intensa. Conclusão: A ressonância magnética foi ferramenta eficiente para avaliação de sobrecarga hepática de ferro em portadores de anemia falciforme. Unitermos: Anemia falciforme; Imagem por ressonância magnética; Ferritina. AbstractResumo

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Heterozigose para hemoglobinopatias em doadores de sangue do Centro de Hemoterapia de Sergipe

Cited by 7 publications

References 5 publications

Estimating the post-neonatal prevalence of sickle cell disease in a Brazilian Population

Estimating the post-neonatal prevalence of sickle cell disease in a Brazilian Population

Prevalence of sickle cell trait in blood donors: A systematic review

Sobrecarga de ferro transfusional em portadores de anemia falciforme: comparação entre ressonância magnética e ferritina sérica

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