A problemática da infecção pelo citomegalovírus em pacientes imunodeprimidos

Granato, Celso

doi:10.1590/s1516-84842001000300001

Cited by 4 publications

(4 citation statements)

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“…Moreover, it has been suggested that it is possible that HSV might have behaved as a risk factor due to the fact that its latency occurs in the sacral and trigeminal ganglia, which may serve as epicenter in the clinical recurrences, thus aggravating the degree of mucositis. Therefore, HSV‐1 could modulate the immune response and collaborate in triggering more complicated clinical problems than those observed in immunocompetent individuals . Whereas, the latency of CMV occurs in the cells of salivary glands, endothelium, and in macrophages, and in spite of having presented a higher prevalence, it did not contribute to the aggravation of mucositis, however, its participation as a possible cofactor responsible for this has not been discarded.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of herpes virus associated with the presence and severity of oral mucositis in children diagnosed with acute lymphoid leukemia

Faria

Silva

Almeida

et al. 2013

J Oral Pathology Medicine

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of herpes virus associated with the presence and severity of oral mucositis in children diagnosed with acute lymphoid leukemia

Faria

Silva

Almeida

et al. 2013

J Oral Pathology Medicine

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“…Na primeira, devido infecção perinatal e na segunda, devido à transmissão sexual ou pelo beijo (JÚNIOR, 2010). Nessas faixas etárias, cerca de 80% da população já se encontrava infectadas, albergando o vírus em vários sítios do organismo, como nas glândulas salivares e em diferentes tipos de leucócitos (GRANATO, 2001).…”

Section: Discussionunclassified

Diagnóstico tardio de Citomegalovirose em recém-nascido pré-termo, por carência de triagem no período gestacional: uma realidade do Brasil - Relato de Caso

Ferreira¹,

Vieira²,

Giacomelli³

et al. 2018

HU Rev

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O citomegalovírus pertence à família do Herpes vírus, e está presente na maior parte da população. A citomegalovirose no período neonatal pode estar associada à transmissão intra-útero por via transplacentária, ou ainda, perinatal. No caso apresentado, destaca-se a demora no diagnóstico e na efetivação da conduta terapêutica visto que, no Brasil, o rastreamento de infecção por citomegalovírus em gestante não faz parte da rotina de pré-natal. O diagnóstico da citomegalovirose neonatal é obtido por meio da realização da cultura do vírus na urina entre o terceiro e o quinto dia de vida, ou ainda, pela realização da Reação em Cadeia de Polimerase. No relato de caso, o tratamento utilizado para a citomegalovirose baseou-se no uso de Ganciclovir (500 mg/10ml por via endovenosa durante três semanas). A dificuldade de estabelecer um diagnóstico precoce da citomegalovirose neonatal ainda representa um dos principais desafios para se alcançar um melhor prognóstico da doença.

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“…Diagnosis and treatment costs and potential side effects should also be considered 21 . Viral load determination by quantitative PCR (real-time PCR) has been reported in literature as a useful technique for HCMV monitoring in immunosuppressed patients 17,19,22 .…”

Section: Martiny Pb Et Al -Comparison Between Pcr and Antigenemia Formentioning

confidence: 99%

Comparison of the performance of polymerase chain reaction and pp65 antigenemia for the detection of human cytomegalovirus in immunosuppressed patients

Martiny

de‐Paris

Machado

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Comparison of the performance of polymerase chain reaction and pp65 antigenemia for the detection of human cytomegalovirus in immunosuppressed patientsComparação do desempenho da reação em cadeia da polimerase e antigenemia pp65 para detecção de citomegalovírus humano em pacientes imunossuprimidos ABSTRACT Introduction: Human cytomegalovirus (HCMV) is often reactive in latently infected immunosuppressed patients. Accordingly, HCMV remains one of the most common infections following solid organ and hemopoietic stem cell transplantations, resulting in significant morbidity, graft loss and occasional mortality. The early diagnosis of HCMV disease is important in immunosuppressed patients, since in these individuals, preemptive treatment is useful. The objective of this study was to compare the performance of the in-house qualitative polymerase chain reaction (PCR) and pp65 antigenemia to HCMV infection in immunosuppressed patients in the Hospital de Clínicas of Porto Alegre (HCPA). Methods: A total of 216 blood samples collected between August 2006 and January 2007 were investigated. Results: Among the samples analyzed, 81 (37.5%) were HCMV-positive by PCR, while 48 (22.2%) were positive for antigenemia. Considering antigenemia as the gold standard, sensitivity, specificity, positive predictive values and negative predictive values for PCR were 87.5%, 76.8%, 51.8% and 95.5% respectively. Conclusions: These results demonstrated that qualitative PCR has high sensitivity and negative predictive value (NPV). Consequently PCR is especially indicated for the initial diagnosis of HCMV infection. In the case of preemptive treatment strategy, identification of patients at high-risk for HCMV disease is fundamental and PCR can be useful tool.

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A problemática da infecção pelo citomegalovírus em pacientes imunodeprimidos

Cited by 4 publications

References 0 publications

Seroprevalence of herpes virus associated with the presence and severity of oral mucositis in children diagnosed with acute lymphoid leukemia

Seroprevalence of herpes virus associated with the presence and severity of oral mucositis in children diagnosed with acute lymphoid leukemia

Diagnóstico tardio de Citomegalovirose em recém-nascido pré-termo, por carência de triagem no período gestacional: uma realidade do Brasil - Relato de Caso

Comparison of the performance of polymerase chain reaction and pp65 antigenemia for the detection of human cytomegalovirus in immunosuppressed patients

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