Hemoglobinopatias no Brasil: um tema inesgotável

Moreira, Haroldo Wilson

doi:10.1590/s1516-84842000000100002

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“…A focus of scientific research since the elucidation of its genetic basis, (2) the study of sickle cell anemia can be considered an inexhaustible subject; (23) the considerable number of academic publications that deal with sickle cell anemia as the central theme is growing annually. In Brazil, there are numerous articles, abstracts and theses on the local problem of sickle cell disease.…”

Section: Introductionmentioning

confidence: 99%

A doença falciforme: um estudo genético-populacional a partir de doadores de sangue em São José dos Campos, São Paulo, Brasil

Moraes¹,

Galioti²

2010

Rev. Bras. Hematol. Hemoter.

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Sickle cell disease is a genetic disease that originated in several different regions, in particular African communities. The disease is present in the Brazilian population. The large number of heterozygotes and the severe clinical symptoms of homozygotes have drawn special attention from the government institutions in Brazil. Since the genetic origin of the disease was elucidated, sickle cell disease has become the focus of an every-growing number of scientific investigations. This investigation was performed to correlate the presence of the sickle cell trait in inhabitants of São José dos Campos, Brazil, with data on immigrants. The study sample consisted of 93,604 blood donors of the Hematology and Hemotherapy Service in São José dos Campos from 2004 to 2008. An analysis of the donors identified 400 heterozygous individuals with the sickle cell trait (Hb S-0.43%) but no homozygotes. The results are completely different from the national pattern and are strongly supported by local history.

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Section: Introductionmentioning

confidence: 99%