Positive association between MET allele (BDNF Val66Met polymorphism) and obsessive-compulsive disorder

Rocha, Felipe Filardi da; Malloy-Diniz, Leandro Fernandes; Lage, Naira Vassalo; Corrêa, Humberto

doi:10.1590/s1516-44462010000300023

Cited by 19 publications

(16 citation statements)

References 5 publications

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“…On the other hand, Hemmings et al [2008] have shown that the BDNF Val/Met variant was associated with OCD in males, with the BDNF Met allele increasing the risk of developing early-onset OCD. da Rocha et al [2010] also reported a positive association between the Met allele and OCD. In the familybased studies, findings have also been inconsistent.…”

Section: Discussionmentioning

confidence: 91%

Brain‐derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive–compulsive disorder

Tükel

Gürvit

Özata

et al. 2012

American J of Med Genetics Pt B

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In the present study, we have tested the hypothesis that brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism is associated with obsessive-compulsive disorder (OCD) and also investigated the association between the BDNF Val66Met polymorphism and the performance on tests measuring executive functions in a sample of patients with OCD. A total of 100 patients diagnosed with OCD according to DSM-IV criteria and 110 control subjects were included in this study. Single nucleotide polymorphism (G/A) leading to Val to Met substitution at codon 66 in BDNF was screened in the DNA samples of all participants. The genotype frequencies of BDNF Val66Met polymorphism were compared in OCD patients and healthy controls. The four subgroups of OCD and healthy control subjects, determined according to being Val homozygous or carrying a Met allele, were also compared according to their performance in a battery of neuropsychological tests of executive functions and verbal memory. There was no significant difference for the allele and genotype distributions of BDNF Val66Met polymorphism between the OCD and healthy control groups. Compared to the other three subgroups, OCD-Met carriers were slower on Trail-Making Test part A (TMT A), part B (TMT B) score and its speed-corrected score (TMT B-A). OCD-Met carriers had also poor performance on verbal fluency tasks and several CVLT measures compared only to the healthy control-Met carriers. These results demonstrate that the BDNF Val66Met polymorphism does not appear to be a risk factor for OCD. However, the presence of a BDNF Met allele, which is a known attenuator of BDNF activity, may be associated with a poorer executive functioning in OCD.

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Section: Discussionmentioning

confidence: 91%

Brain‐derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive–compulsive disorder

Tükel

Gürvit

Özata

et al. 2012

American J of Med Genetics Pt B

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“…Therefore, 66Val carriers have an increased euphoric effect after drug abuse, which makes them more vulnerable to have drug abuse. Previous studies found that the Met allele might be a risk allele in the development of obsessive-compulsive disorder (OCD) and was associated with an earlier age at onset of OCD in men (Hemmings et al, 2008;Rocha et al, 2010). These findings suggested that the BDNF Val66Met polymorphism may have genetic pleiotropy, which is the ability of a mutation in a single gene to give rise to multiple phenotypic outcomes, and, thus, simultaneously convey separate advantageous traits and disadvantageous traits in the same organism (Hong et al, 2011).…”

Section: Discussionmentioning

confidence: 98%

Influence of Brain-Derived Neurotrophic Factor Genetic Polymorphisms on the Ages of Onset for Heroin Dependence in a Chinese Population

Meng

Lan

Wang

et al. 2012

Genetic Testing and Molecular Biomarkers

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Aim:The study aims at evaluating the association between brain-derived neurotrophic factor (BDNF) gene polymorphisms and heroin-dependent patients in the Chinese population. Three polymorphisms of the BDNFgene (rs10835210, rs16917234, and rs6265) in 486 heroin-dependent patients and in 226 healthy controls were genotyped for analyzing the association of these polymorphisms with age of onset of heroin dependence. We defined the healthy cases as ''unknown phenotype'' and used the endophenotype (behavior traits) to stratify the heroin dependents group on the basis of self-reporting traits for examining the association between BDNF polymorphisms (rs10835210, rs16917234, and rs6265) and heroin dependence. Results: Allelic distributions of BDNF gene polymorphisms did not differ significantly between heroin-dependent patients and controls. However, we found that the AA carriers of BDNF rs6265 had an earlier onset of heroin dependence and a clearer tendency of family history of heroin-dependent than GG carriers after controlling behavior characteristics across rs6265 genotypes. Conclusions: Our findings suggested that the BDNF genetic polymorphism (rs6265) may have effects on the age of onset of heroin dependence among the Chinese population. The BDNF gene could contribute to vulnerabilities to heroin dependence.

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“…We also carried out a meta-analysis of all available published association studies of the BDNF Val-66-Met polymorphism and OCD on PubMed (until 31 December 2013), with 13 studies in total, including our current family-based and case-control studies (Hall et al, 2003;Mossner et al, 2005;Klaffke et al, 2006;Dickel et al, 2007;Wendland et al, 2007;Alonso et al, 2008;Hemmings et al, 2008;Katerberg et al, 2009;Rocha et al, 2010;Tükel et al, 2012;Márquez et al, 2013) using the Catmap package on R software (version 2.9.2, Vienna, Austria) to combine both case-control (N = 8 studies) and family (N = 5 studies) samples (Nicodemus, 2008).…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis and association of brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorder

Zai

Arnold

et al. 2015

Psychiatric Genetics

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Obsessive-compulsive disorder (OCD) is a severe psychiatric condition with a clear genetic component (Nicolini et al., 2009) in which neurodevelopmental mechanisms may be etiologically important. Brain-derived neurotrophic factor (BDNF) is an interesting candidate for molecular analysis in OCD on the basis of potential functional relevance, positive association studies, and reported interaction between this gene and other neurotransmitters implicated in this disorder.

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Positive association between MET allele (BDNF Val66Met polymorphism) and obsessive-compulsive disorder

Cited by 19 publications

References 5 publications

Brain‐derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive–compulsive disorder

Brain‐derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive–compulsive disorder

Influence of Brain-Derived Neurotrophic Factor Genetic Polymorphisms on the Ages of Onset for Heroin Dependence in a Chinese Population

Meta-analysis and association of brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorder

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