Bipolar disorder and age-related functional impairment

Cacilhas, Alice Aita de; Magalhães, Pedro Vieira da Silva; Ceresér, Keila Maria Mendes; Walz, Julio Cesar; Weyne, Fernanda; Rosa, Adriane Ribeiro; Vieta, Eduard; Kapczinski, Flávio

doi:10.1590/s1516-44462009000400012

Cited by 20 publications

(14 citation statements)

References 16 publications

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“…35 FAST is a valid instrument for evaluation of functioning in patients with BD. 30,31 However, it poses some limitations, such as the limited number of questions and the fact it is rated by a clinician. Another major limitation is that, as all patients were experiencing a depressive episode, their depressive symptoms may have affected vigilance and engagement during the cognitive assessment, thus impairing cognitive performance.…”

Section: Discussionmentioning

confidence: 99%

“…This instrument was developed to evaluate functional impairment and has been validated in patients with BD, showing excellent testretest reliability and internal consistency, with a Cronbach's alpha coefficient of 0.95 for the whole scale and excellent test-retest agreement for total FAST scores (r = 0.90; p o 0.001). 30,31 Previous studies have shown that patients with BD have lower FAST functioning scores compared with healthy controls, and that functional impairment is age-related in patients with BD. 31 …”

Section: Assessmentmentioning

confidence: 99%

“…30,31 Previous studies have shown that patients with BD have lower FAST functioning scores compared with healthy controls, and that functional impairment is age-related in patients with BD. 31 …”

Section: Assessmentmentioning

confidence: 99%

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Cognition and functioning in bipolar depression

Kapczinski

Narvaez

Magalhães

et al. 2016

Rev. Bras. Psiquiatr.

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Objectives: Depressive symptoms are associated with worse outcomes in patients with bipolar disorder (BD). However, scarce data are available regarding neurocognitive profiles across different areas of functioning among BD patients with moderate and severe depression. Our objective was to assess cognition and global functioning in a group of patients with bipolar depression. Methods: Data were available for 100 patients with bipolar depression (78% female) and 70 controls (64% female) paired by age and education level. Cognitive function was assessed with a neuropsychological test battery. Functioning was assessed with the Functioning Assessment Short Test. Results: In patients, severe depression was associated with poorer cognitive performance on measures of executive function. Patients with severe depression showed worse global functioning than those with moderate depression (z = 2.54, p = 0.011). In patients with severe depression, lower global functioning was associated with lower scores in working memory (r = -0.200, p = 0.010), and executive function (r = -0.210, p = 0.007; and r = 0.293, p o 0.001). Conclusion: Our findings suggest cognitive impairment and global functioning impairment are associated with the severity of depressive symptoms in bipolar depression. Intensive treatment of depressive symptoms in patients with BD is crucial to improve cognitive functioning and, consequently, functional outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Assessmentmentioning

confidence: 99%

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Cognition and functioning in bipolar depression

Kapczinski

Narvaez

Magalhães

et al. 2016

Rev. Bras. Psiquiatr.

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“…Accumulation of such toxicity becomes more evident at later stages of illness (33)(34)(35)(36)(37)(38), causing less efficient cellular resilience mechanisms that may be leading to a pathological reorganization between different brain areas (39). This rewiring of the brain within the context of clinical and cognitive deterioration is called "neuroprogression".…”

mentioning

confidence: 99%

Bipolar bozuklukta allostaz ve allostatik yükü yeniden değerlendirmek

Özerdem¹

2015

Dusunen Adam

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“…1 However, we feel that it is important to remind our readers that major functional impairment is also present in schizophrenia, although it is rarely measured in a standardized way in these patients.…”

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confidence: 99%