2009
DOI: 10.1590/s1516-44462009000100012
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Abstract: These results suggest that serum levels of brain-derived neurotrophic factor, as opposed to what has been described in mood disorders, are increased in posttraumatic stress disorder as well as in acute stress disorder.

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Cited by 18 publications
(13 citation statements)
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“…Similarly, it may reflect an attempt to consolidate a safe memory or maintenance of fear memory. In the case reports of Hauck et al [7], a positive association of PTSD severity with serum BDNF levels was reported, which is consistent with our data.…”
Section: Discussionsupporting
confidence: 93%
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“…Similarly, it may reflect an attempt to consolidate a safe memory or maintenance of fear memory. In the case reports of Hauck et al [7], a positive association of PTSD severity with serum BDNF levels was reported, which is consistent with our data.…”
Section: Discussionsupporting
confidence: 93%
“…Our results also indicated a significant positive correlation between changes in serum BDNF levels over the 6 months and PTSD severity at 6-month follow-up. These findings are in line with previous clinical observations [7,8] and with an animal study showing an association between chronic stress and increased plasma BDNF[23]. …”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…Of particular relevance are the observations by Kozolovsky et al (2007) who documented a down-regulation of Bdnf mRNA in the CA1 region of animals exhibiting PTSD-like behavioral stress responses. Furthermore, clinical studies have also demonstrated that BDNF serum levels are altered in PTSD patients (Dell’Osso et al, 2009; Grassi-Oliveira et al, 2008; Hauck et al, 2009, 2010). Together, research efforts have made it clear that the hippocampal Bdnf gene is particularly susceptible to modulation by stress.…”
Section: Discussionmentioning
confidence: 99%
“…This mechanism is similar to that observed in the progression of bipolar disorder 35 and was observed by Hauck et al in patients with long-term PTSD. 36 Clearly, additional studies with prospective longitudinal designs are necessary to test these hypotheses and to outline the mechanisms involved in the neurobiology of trauma exposure.…”
Section: Discussionmentioning
confidence: 99%