Cataract occurrence in patients treated with antipsychotic drugs

Souza, Victor Carneiro de; Filho, Francisco José Rodrigues de Moura; Souza, Fábio Gomes de Matos e; Rocha, Camila Farias; Furtado, Fernando Antônio Mendes Lopes; Gonçalves, Tiago Bessa Almeida; Vasconcelos, Karla Feitosa Ximenes

doi:10.1590/s1516-44462008000300008

Cited by 24 publications

(14 citation statements)

References 19 publications

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“…Poor performance on tests of visual perception (and other cognitive tasks involving visual stimuli) is assumed to reflect the process under investigation, and little attention has been paid to the possibility that reduced visual acuity could play a role. We believe this needs to change, given past findings of poorer visual acuity in schizophrenia, but not other psychotic disorder, patients (including that caused by medication) ( Viertio et al, 2007 ), with one study reporting that close to 70% of a schizophrenia patient sample had untreated visual acuity problems ( Smith et al, 1997 ) [although some studies reported lower rates [e.g., 26% ( Souza et al, 2008 )] this is still excessive]. While the role of acuity changes in performance on perceptual (and other) tasks in driving between group differences in studies of schizophrenia is generally not known, recent evidence suggests a role.…”

Section: Visual Acuity Changes and Their Implications In Schizophrenimentioning

confidence: 99%

Schizophrenia and the eye

Silverstein

Rosen

2015

Schizophrenia Research: Cognition

149

127

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Although visual processing impairments are common in schizophrenia, it is not clear to what extent these originate in the eye vs. the brain. This review highlights potential contributions, from the retina and other structures of the eye, tovisual processing impairments in schizophrenia and high-risk states. A second goal is to evaluate the status of retinal abnormalities as biomarkers for schizophrenia. The review was motivated by known retinal changes in other disorders (e.g., Parkinson's disease, multiple sclerosis), and their relationships to perceptual and cognitive impairments, and disease progression therein. The evidence reviewed suggests two major conclusions. One is that there are multiple structural and functional disturbances of the eye in schizophrenia, all of which could be factors in the visual disturbances of patients. These include retinal venule widening, retinal nerve fiber layer thinning, dopaminergic abnormalities, abnormal ouput of retinal cells as measured by electroretinography (ERG), maculopathies and retinopathies, cataracts, poor acuity, and strabismus. Some of these are likely to be illness-related, whereas others may be due to medication or comorbid conditions. The second conclusion is that certain retinal findings can serve as biomarkers of neural pathology, and disease progression, in schizophrenia. The strongest evidence for this to date involves findings of widened retinal venules, thinning of the retinal nerve fiber layer, and abnormal ERG amplitudes. These data suggest that a greater understanding of the contribution of retinal and other ocular pathology to the visual and cognitive disturbances of schizophrenia is warranted, and that retinal changes have untapped clinical utility.

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Section: Visual Acuity Changes and Their Implications In Schizophrenimentioning

confidence: 99%

Schizophrenia and the eye

Silverstein

Rosen

2015

Schizophrenia Research: Cognition

149

127

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“…[9,10] Both the systemic and local steroid administration would cause the cataract, [11,12] while certain medications including phenothiazines, amiodarone, statin and metformin may also increase the possibility of cataract formation. [13][14][15][16] Diabetes mellitus (DM) is a metabolic disorder featuring with hyperglycemia and insulin dysregulation which influence eye mainly on the retina and cataract development. [17][18][19][20][21] The risk of cataract formation can be up to five-folds in patients with DM compared to non-DM induviduals.…”

Section: Introductionmentioning

confidence: 99%

The elevated risk of sight-threatening cataract in diabetes with retinopathy: a cohort study

Nien

Lee

Chen

et al. 2020

Preprint

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Background To survey the effect of diabetic retinopathy (DR) on the development of sight-threatening cataract via National Health Insurance Research Database of Taiwan.Methods Patients diagnosed with diabetes mellitus (DM) and DR were enrolled in the study group. The age and gender-matched DM individuals without DR and patients without DM served as the DM control group and non-DM control group, both with 1:4 ratios. The outcome was set as the performance of cataract surgery. Cox proportional hazard regression was used to calculate the adjusted hazard ratio (aHR) of DR with considering multiple factors of cataract formation.Results A total of 3,297 DR patients, 13,188 DM control patients and 13,188 non-DM controls were enrolled. There were 919 events (27.87 percent) of sight-threatening cataract in the study group while another 1,108 events (8.40 percent) in the DM control group and 957 events (7.26 percent) in the non-DM control group. After multivariable analysis, the study group showed a higher aHR of cataract surgery (2.93, 95% CI: 2.60-3.30) and a higher cumulative probability of cataract surgery compared to both the DM control and non-DM control groups (both Log rank P<0.001). Besides, both the proliferative DR (3.90, 95% CI: 3.42-4.45) and non-proliferative DR (2.35, 95% CI: 2.08-2.65) subgroups showed a higher aHR of cataract surgery than the DM control group.Conclusion The presence of DR will increase the risk for development of sight-threatening cataract that surgery is warranted, and the effect is prominent in both the proliferative DR and non-proliferative DR.

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“…Cataract formation associated with the use of atypical antipsychotics has been reported with olanzapine, ziprasidone, and risperidone. [3] A thorough review of literature showed only a single case report of cataract caused by long-term use of clozapine, with no case been reported from India. [4] We herewith report a rare case of clozapine-induced cataract in a young Indian female.…”

Section: Introductionmentioning

confidence: 99%

Clozapine-induced cataract in a young female

2016

Journal of Pharmacology and Pharmacotherapeutics

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A variety of systemic drugs including corticosteroids, amiodarone and antipsychotics have been known to cause cataract formation. Typical antipsychotics such as chlorpromazine have been reported to cause cataract formation in varying rates ranging from 22% to 80%. Cataract as an adverse effect resulting from the long term use of atypical antipsychotic has rarely been mentioned in literature, and there is only a single case report of cataract formation from prolonged use of clozapine. We report a rare case of clozpine induced cataract in a young female. The patient was advised to consult her psychiatrist for a change of drug and to undergo cataract surgery.

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Cataract occurrence in patients treated with antipsychotic drugs

Cited by 24 publications

References 19 publications

Schizophrenia and the eye

Schizophrenia and the eye

The elevated risk of sight-threatening cataract in diabetes with retinopathy: a cohort study

Clozapine-induced cataract in a young female

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