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Cited by 6 publications
(6 citation statements)
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References 36 publications
(41 reference statements)
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“…Transgenic mice expressing human α‐synuclein A53T under the control of the prion protein promoter were obtained from Jackson Laboratory (Giasson et al,2002). At 9 months of age, hemizygous transgenic littermates were fed either mouse chow (PicoLab Rodent Diet 20, Purina 5053, Purina, Richmond, IN) containing 0.255% LiCl (Lima et al,2008) or the same chow without LiCl in age‐ and sex‐matched siblings (n = 12 males and n = 10 females in each group) for a 3‐month period. All the mice were then exposed to chronic PQ/MB or vehicle (saline) at 12 months of age.…”
Section: Methodsmentioning
confidence: 99%
“…Transgenic mice expressing human α‐synuclein A53T under the control of the prion protein promoter were obtained from Jackson Laboratory (Giasson et al,2002). At 9 months of age, hemizygous transgenic littermates were fed either mouse chow (PicoLab Rodent Diet 20, Purina 5053, Purina, Richmond, IN) containing 0.255% LiCl (Lima et al,2008) or the same chow without LiCl in age‐ and sex‐matched siblings (n = 12 males and n = 10 females in each group) for a 3‐month period. All the mice were then exposed to chronic PQ/MB or vehicle (saline) at 12 months of age.…”
Section: Methodsmentioning
confidence: 99%
“…23) Although the security range of lithium's therapeutic window for human clinical use has been established between: 0.6 to 1.2 mmol/l serum levels this does not exclude the occasional toxic consequences of lithium. 24) The measurement of serum lithium concentration, which is the diagnostic method currently used to monitor lithium levels in bipolar patients, seems to be inaccurate since it has been pointed that lithium serum concentration did not satisfactorily reflect the tissue level. 24) New methods to predict the best lithium dosages for patients are required to allow the growing clinical use of lithium salts.…”
mentioning
confidence: 99%
“…24) The measurement of serum lithium concentration, which is the diagnostic method currently used to monitor lithium levels in bipolar patients, seems to be inaccurate since it has been pointed that lithium serum concentration did not satisfactorily reflect the tissue level. 24) New methods to predict the best lithium dosages for patients are required to allow the growing clinical use of lithium salts. These findings highlight the toxicity of lithium and emphasize that there are a number of features on the clinical use of lithium that are yet to be revealed.…”
mentioning
confidence: 99%
“…Moreover, age, renal function, pregnancy, co-administered medications and lactation can all significantly affect the plasma Li + concentration, thus influencing pharmacodynamic action [12]. Although realtime monitoring of the plasma Li + concentration in human patients is routinely achieved using a clinical laboratory spectrophotometric enzymatic assay (SEA), this method has not been evaluated for use in horses [13,14]. Although realtime monitoring of the plasma Li + concentration in human patients is routinely achieved using a clinical laboratory spectrophotometric enzymatic assay (SEA), this method has not been evaluated for use in horses [13,14].…”
Section: Introductionmentioning
confidence: 99%
“…In the light of the narrow therapeutic index when used for human patients, Li + dosing should be carefully monitored. Although realtime monitoring of the plasma Li + concentration in human patients is routinely achieved using a clinical laboratory spectrophotometric enzymatic assay (SEA), this method has not been evaluated for use in horses [13,14]. Therefore, the objectives of this study were to determine Li + pharmacokinetics following i.v.…”
Section: Introductionmentioning
confidence: 99%