Pituitary volume and the effects of phototherapy in patients with seasonal winter depression: a controlled study

Miranda-Scippa, Ângela; Pires, Maria Laura Nogueira; Handfas, Benjamim Wolf; Marie, Suely Kazue Nagahashi; Calil, Helena Maria

doi:10.1590/s1516-44462008000100010

Cited by 11 publications

(5 citation statements)

References 28 publications

(29 reference statements)

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“…Morphological changes in the pituitary gland are especially significant in various endocrine and mental disorders such as schizophrenia, major depression and other neurological diseases [6,15,30]. The size of pituitary gland can be related to these diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors have considered the gland height measured by MRI to be a reliable means of evaluation of gland size [44]. Other researchers estimated pituitary gland volume using the planimetric methods where cross sectional area is multiplied by section thickness [30,45]. There is no study using stereological methods such as the Cavalieri principle.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, our results are similar to those of Di Chiro and Nelson [14], which used water filled method as gold standard. Recently, Miranda-Scippa et al [30] reported that estimated pituitary volumes using planimetric method in winter and summer seasons were 620.3 ± 130.5 mm 3 and 635.2 ± 146.2 mm 3 . The results of their study showed no difference in the pituitary volume of the healthy volunteers in winter or summer [30] In more recent studies, pituitary gland volume was estimated by some researches using planimetry method in healthy volunteers [2,[47][48][49][50] and their results ranged from 660 to 959 mm 3 .…”

Section: Discussionmentioning

confidence: 99%

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Comparison of three methods for the estimation of the pituitary gland volume using magnetic resonance imaging: a stereological study

et al. 2010

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Stereological techniques using point counting and planimetry have been used to estimate pituitary gland volume. However, many studies have estimated pituitary gland volume by the mathematical approach the elliptic formula. The objective of the current study was to determine pituitary gland volume using stereological methods and elliptic formula on magnetic resonance imaging (MRI). In this study, pituitary gland volumes were estimated in a total of 28 subjects (22 females, 6 males,) who were free of any pituitary or neurological symptoms and signs. The mean ± SD pituitary gland volumes for the point counting, planimetry and elliptic formulae groups were 582.14 ± 140.16 mm³, 610.08 ± 133.17 mm³, and 432.82 ± 147.38 mm³, respectively. The mean CE for the pituitary gland volume estimates derived from the point counting technique was 8.07%. No significant difference was found between point counting and planimetric methods for the pituitary gland volume (P > 0.05). In addition, there was a 26.14 and 29.71% underestimation of pituitary volume as measured by the elliptic formula compared to the point counting and planimetric techniques, respectively. From these results, it can be concluded that stereological techniques are unbiased, efficient and reliable methods and are ideally suitable for in vivo examination of MRI data for pituitary gland volume estimation. Hence, we suggest that estimating pituitary gland volume using MRI study and stereology may be clinically relevant for pituitary surgeons for the investigation of the structure and function of the pituitary gland.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparison of three methods for the estimation of the pituitary gland volume using magnetic resonance imaging: a stereological study

et al. 2010

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“…For instance, studies have shown that time‐based biotherapies such as awakening and phototherapy can effectively treat depression 28 . These important findings show a close relationship between sleep disorders caused by abnormal circadian rhythms and depression 29 . Since biological rhythms are regulated by clock genes, rhythm disorders in depression may also be related to changes in clock gene expression 30‐32 …”

Section: Discussionmentioning

confidence: 99%

Depression‐like behavior is associated with lower Per2 mRNA expression in the lateral habenula of rats

et al. 2020

Genes Brain and Behavior

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Circadian rhythm dysfunction is primary symptom of depression and is closely related to depression onset. The role of the lateral habenula (LHb) of the thalamus in the pathogenesis of depression has been a research topic of great interest. The neuronal activity of this structure has circadian characteristics, which are related to the regulation of circadian rhythms. However, in depression model of rats, the role of clock genes in the LHb has not been assessed. To address this gap, we used a clomipramine (CLI) injection‐induced depression model in rats to assess the daily expression of rhythmic genes in the LHb and depression‐like behavior in rats at multiple time points. In determining the role of the Per2 gene in the development of depression‐like behavior in the LHb, we found that the expression of this clock gene differed in a circadian manner. Per2 expression was also significantly decreased in CLI‐treated rats in late afternoon (17:00) and in the middle of the night (1:00). Furthermore, silencing Per2 in the LHb of normal rats induced depression‐like behavior at night, suggesting that Per2 may play an important role in the pathogenesis of depression. Collectively, these results indicate that decreased Per2 expression in the LHb may be related to increased depression‐like behavior at night in depression model of rats.

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“…In regard to other Brazilian states, a group from the Federal University of Bahia (UFBA) undertook MRI studies of bipolar disorder in collaboration with other centers. [105][106][107] At the Federal University of Rio Grande do Norte (UFRN) Brain Institute, physicists and neuroscientists have pioneered neuroimaging investigations of humans using the psychedelic drug ayahuasca, 108,109 and have established collaborations with other groups in Brazil 110 and abroad. 111 Psychiatrists from the Federal University of Ceará (UFCE) have also collaborated in original studies of mood disorders with other groups in Brazil 34 and abroad.…”

Section: Psychiatric Neuroimaging In Brazilmentioning

confidence: 99%

Psychiatric neuroimaging research in Brazil: historical overview, current challenges, and future opportunities

Busatto

Rosa

Squarzoni

et al. 2021

Braz. J. Psychiatry

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The last four decades have witnessed tremendous growth in research studies applying neuroimaging methods to evaluate pathophysiological and treatment aspects of psychiatric disorders around the world. This article provides a brief history of psychiatric neuroimaging research in Brazil, including quantitative information about the growth of this field in the country over the past 20 years. Also described are the various methodologies used, the wealth of scientific questions investigated, and the strength of international collaborations established. Finally, examples of the many methodological advances that have emerged in the field of in vivo neuroimaging are provided, with discussion of the challenges faced by psychiatric research groups in Brazil, a country of limited resources, to continue incorporating such innovations to generate novel scientific data of local and global relevance.

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Pituitary volume and the effects of phototherapy in patients with seasonal winter depression: a controlled study

Abstract: Pituitary volume and the effects of phototherapy in patients with seasonal winter depression: a controlled study Volume da pituitária e os efeitos da fototerapia em pacientes com depressão sazonal de inverno: um estudo controlado

Cited by 11 publications

References 28 publications

Comparison of three methods for the estimation of the pituitary gland volume using magnetic resonance imaging: a stereological study

Comparison of three methods for the estimation of the pituitary gland volume using magnetic resonance imaging: a stereological study

Depression‐like behavior is associated with lower Per2 mRNA expression in the lateral habenula of rats

Psychiatric neuroimaging research in Brazil: historical overview, current challenges, and future opportunities

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